公开(公告)号：EP1276702A2

公开(公告)日：2003-01-22

申请号：EP01922986.3

申请日：2001-03-30

申请人： GENENTECH, INC.

发明人： LOWE, David, G. ,  MARSTERS James, C., Jr. ,  ROBBIE, Edward, P. ,  SMITH, Victoria

IPC分类号： C03C17/34 ,  C12Q1/68

CPC分类号： G01N33/54353 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00385 ,  B01J2219/00427 ,  B01J2219/00529 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00677 ,  B01J2219/00722 ,  B82Y30/00 ,  C03C17/3405 ,  C12Q1/6837 ,  C40B40/06 ,  C40B60/14 ,  G01N33/6893 ,  G01N2800/24

摘要： Compositions and methods for improving detection sensitivity in nucleic acid microarray analysis are disclosed, including methods of purifying nucleic acids, methods of synthesizing fluorescent DNA probes, methods of hybridization, and methods of activating a substrate for target molecule attachment are disclosed.