公开(公告)号：EP3224258A1

公开(公告)日：2017-10-04

申请号：EP15816578.7

申请日：2015-11-25

申请人： Genentech, Inc. ,  Constellation Pharmaceuticals, Inc.

发明人： ROMERO, F. Anthony ,  MAGNUSON, Steven ,  PASTOR, Richard ,  TSUI, Vickie Hsiao-Wei ,  MURRAY, Jeremy ,  CRAWFORD, Terry ,  ALBRECHT, Brian, K. ,  COTE, Alexandre ,  TAYLOR, Alexander, M. ,  LAI, Kwong Wah ,  CHEN, Kevin, X. ,  BRONNER, Sarah ,  ADLER, Marc ,  EGEN, Jackson ,  LIAO, Jiangpeng ,  WANG, Fei ,  CYR, Patrick ,  ZHU, Bing-Yan ,  KAUDER, Steven

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00 ,  A61P29/00 ,  A61P37/00

CPC分类号： A61K31/437 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/498 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5415 ,  A61K31/55 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00

摘要： The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

摘要翻译： 本发明涉及式（I）或式（II）的化合物及其盐，其中式（I）的R 1 -R 4和式（II）的R 1 -R 3具有本文所定义的任何值， 及其用途。 该化合物可用作CBP和/或EP300的抑制剂。 还包括药物组合物，其包含式（II）的式（I）化合物或其药学上可接受的盐，以及使用该化合物和盐治疗各种CBP和/或EP300介导的病症的方法。

公开(公告)号：EP3224258B1

公开(公告)日：2019-08-14

申请号：EP15816578.7

申请日：2015-11-25

申请人： Genentech, Inc. ,  Constellation Pharmaceuticals, Inc.

发明人： ROMERO, F. Anthony ,  MAGNUSON, Steven ,  PASTOR, Richard ,  TSUI, Vickie Hsiao-Wei ,  MURRAY, Jeremy ,  CRAWFORD, Terry ,  ALBRECHT, Brian, K. ,  COTE, Alexandre ,  TAYLOR, Alexander, M. ,  LAI, Kwong Wah ,  CHEN, Kevin, X. ,  BRONNER, Sarah ,  ADLER, Marc ,  EGEN, Jackson ,  LIAO, Jiangpeng ,  WANG, Fei ,  CYR, Patrick ,  ZHU, Bing-Yan ,  KAUDER, Steven

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00 ,  A61P29/00 ,  A61P37/00

公开(公告)号：EP3632915A1

公开(公告)日：2020-04-08

申请号：EP19191423.3

申请日：2015-11-25

申请人： GENENTECH, INC. ,  Constellation Pharmaceuticals, Inc.

发明人： ROMERO, F. Anthony ,  MAGNUSON, Steven ,  PASTOR, Richard ,  TSUI, Vickie Hsiao-Wei ,  MURRAY, Jeremy ,  CRAWFORD, Terry ,  ALBRECHT, Brian, K. ,  COTE, Alexandre ,  TAYLOR, Alexander, M. ,  LAI, Kwong Wah ,  CHEN, Kevin, X. ,  BRONNER, Sarah ,  ADLER, Marc ,  EGEN, Jackson ,  LIAO, Jiangpeng ,  WANG, Fei ,  CYR, Patrick ,  ZHU, Bing-Yan ,  KAUDER, Steven

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00 ,  A61P29/00 ,  A61P37/00

摘要： The present invention relates to compounds of formula (I) or formula (II):

and to salts thereof, wherein R 1 -R 4 of formula (I) and R 1 -R 3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.