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1.发明公开METHODS FOR IDENTIFYING TUMORS THAT ARE RESPONSIVE TO TREATMENT WITH ANTI-ErbB2 ANTIBODIES 审中-公开识别对抗-ErbB2抗体治疗有反应的肿瘤的方法
公开(公告)号：EP1585966A3
公开(公告)日：2005-10-26
申请号：EP03755724.6
申请日：2003-07-11
发明人： KOLL, Hans , BOSSENMAIER, Birgit , MÜLLER, Hans-Joachim , SLIWKOWSKI, Mark, X. , KELSEY, Stephen, Michael
IPC分类号： G01N1/00
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2.发明公开METHODS FOR IDENTIFYING TUMORS THAT ARE RESPONSIVE TO TREATMENT WITH ANTI-ErbB2 ANTIBODIES 有权癌症治疗与抗ErbB2抗体的rhuMAb 2C4
公开(公告)号：EP1585966A2
公开(公告)日：2005-10-19
申请号：EP03755724.6
申请日：2003-07-11
发明人： KOLL, Hans , BOSSENMAIER, Birgit , MÜLLER, Hans-Joachim , SLIWKOWSKI, Mark, X. , KELSEY, Stephen, Michael
IPC分类号： G01N1/00
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/24 , G01N33/57492 , G01N2333/485 , G01N2333/71 , G01N2800/52
摘要： Tumors are identified as responsive to treatment with anti-HER2 antibodies by detecting the presence of a HER2/HER3 and/or HER2/HER1 protein complex or for HER2 phosphorylation in a sample of tumor cells. Patients suffering from a tumor comprising HER/2/HER1 and/or HER2/HER3 heterodimers and/or HER2 phosphorylation are treated with anti-HER2 antibodies, such as rhuMAb 2C4.
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公开(公告)号：EP1585966B1
公开(公告)日：2011-11-30
申请号：EP03755724.6
申请日：2003-07-11
发明人： KOLL, Hans , BOSSENMAIER, Birgit , MÜLLER, Hans-Joachim , SLIWKOWSKI, Mark, X. , KELSEY, Stephen, Michael
IPC分类号： A61K39/395
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/24 , G01N33/57492 , G01N2333/485 , G01N2333/71 , G01N2800/52
摘要： Tumors are identified as responsive to treatment with anti-HER2 antibodies by detecting the presence of a HER2/HER3 and/or HER2/HER1 protein complex or for HER2 phosphorylation in a sample of tumor cells. Patients suffering from a tumor comprising HER/2/HER1 and/or HER2/HER3 heterodimers and/or HER2 phosphorylation are treated with anti-HER2 antibodies, such as rhuMAb 2C4.
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公开(公告)号：EP1585966B8
公开(公告)日：2012-03-07
申请号：EP03755724.6
申请日：2003-07-11
发明人： KOLL, Hans , BOSSENMAIER, Birgit , MÜLLER, Hans-Joachim , SLIWKOWSKI, Mark, X. , KELSEY, Stephen, Michael
IPC分类号： A61K39/395
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/24 , G01N33/57492 , G01N2333/485 , G01N2333/71 , G01N2800/52
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公开(公告)号：EP2408817A1
公开(公告)日：2012-01-25
申请号：EP10710142.0
申请日：2010-03-19
CPC分类号： A61K47/48569 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92
摘要： The invention provides anti-HER antibodies, including multispecific anti-HER antibodies, compositions comprising and methods of using these antibodies. Also provided herein are EGFR/HER3 multispecific antibodies that are less toxic than traditional EGFR antagonists.
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公开(公告)号：EP2408817B1
公开(公告)日：2016-03-16
申请号：EP10710142.0
申请日：2010-03-19
CPC分类号： A61K47/48569 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92
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公开(公告)号：EP1351744B1
公开(公告)日：2007-10-03
申请号：EP01966399.6
申请日：2001-08-29
申请人： GENENTECH, INC.
CPC分类号： C07K14/82 , A61K38/00 , C07K14/4756 , C07K16/32 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30 , G01N33/5061
摘要： The present invention concerns methods and means for controlling excessive proliferation and/or migration of smooth muscle cells, and in particular for treating stenosis, by using antagonists of a native ErbB4 receptor. The invention further concerns a method for the identification of ErbB4 agonists and antagonists capable of inhibiting or enhancing the proliferation or migration of smooth muscle cells.
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公开(公告)号：EP1189634B1
公开(公告)日：2007-02-28
申请号：EP00939992.4
申请日：2000-06-23
申请人： GENENTECH, INC.
发明人： SLIWKOWSKI, Mark, X.
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/32 , A61K39/39558 , A61K47/6809 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , A61K31/365 , A61K31/335 , A61K2300/00
摘要： The present application discloses treatment of prostate cancer with anti-ErbB2 antibodies.
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9.发明公开METHODS OF TREATMENT USING ANTI-ErbB ANTIBODY-MAYTANSINOID CONJUGATES 审中-公开治疗方法采用ERB抗体 - MAYNTASINOID结合物
公开(公告)号：EP1191944A2
公开(公告)日：2002-04-03
申请号：EP00941649.6
申请日：2000-06-23
申请人： Genentech, Inc.
IPC分类号： A61K47/48
CPC分类号： A01K67/0278 , A01K67/0271 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/0331 , A61K47/6809 , C12N15/8509
摘要： The application concerns methods of treatment using anti-ErbB receptor antibody-maytansinoid conjugates, and articles of manufacture suitable for use in such methods. In particular, the invention concerns ErbB receptor-directed cancer therapies, using anti-ErbB receptor antibody-maytansinoid conjugates.
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10.发明公开
公开(公告)号：EP1846558A2
公开(公告)日：2007-10-24
申请号：EP06734871.4
申请日：2006-02-09
申请人： GENENTECH, INC.
IPC分类号： C12N15/11 , C12N9/64 , A61K39/395 , G01N33/574 , A61P35/00
CPC分类号： G01N33/57488 , A61K2039/505 , C07K16/30 , C07K16/32 , C07K2317/73 , C07K2319/30 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53 , G01N33/574 , G01N2333/96486
摘要： The present application describes using antagonists of matrix metalloproteases (MMPs), especially of MMP-15, for inhibiting HER2 shedding.
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