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公开(公告)号：EP1585966B1
公开(公告)日：2011-11-30
申请号：EP03755724.6
申请日：2003-07-11
发明人： KOLL, Hans , BOSSENMAIER, Birgit , MÜLLER, Hans-Joachim , SLIWKOWSKI, Mark, X. , KELSEY, Stephen, Michael
IPC分类号： A61K39/395
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/24 , G01N33/57492 , G01N2333/485 , G01N2333/71 , G01N2800/52
摘要： Tumors are identified as responsive to treatment with anti-HER2 antibodies by detecting the presence of a HER2/HER3 and/or HER2/HER1 protein complex or for HER2 phosphorylation in a sample of tumor cells. Patients suffering from a tumor comprising HER/2/HER1 and/or HER2/HER3 heterodimers and/or HER2 phosphorylation are treated with anti-HER2 antibodies, such as rhuMAb 2C4.
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2.发明公开METHODS FOR IDENTIFYING TUMORS THAT ARE RESPONSIVE TO TREATMENT WITH ANTI-ErbB2 ANTIBODIES 审中-公开识别对抗-ErbB2抗体治疗有反应的肿瘤的方法
公开(公告)号：EP1585966A3
公开(公告)日：2005-10-26
申请号：EP03755724.6
申请日：2003-07-11
发明人： KOLL, Hans , BOSSENMAIER, Birgit , MÜLLER, Hans-Joachim , SLIWKOWSKI, Mark, X. , KELSEY, Stephen, Michael
IPC分类号： G01N1/00
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3.发明公开METHODS FOR IDENTIFYING TUMORS THAT ARE RESPONSIVE TO TREATMENT WITH ANTI-ErbB2 ANTIBODIES 有权癌症治疗与抗ErbB2抗体的rhuMAb 2C4
公开(公告)号：EP1585966A2
公开(公告)日：2005-10-19
申请号：EP03755724.6
申请日：2003-07-11
发明人： KOLL, Hans , BOSSENMAIER, Birgit , MÜLLER, Hans-Joachim , SLIWKOWSKI, Mark, X. , KELSEY, Stephen, Michael
IPC分类号： G01N1/00
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/24 , G01N33/57492 , G01N2333/485 , G01N2333/71 , G01N2800/52
摘要： Tumors are identified as responsive to treatment with anti-HER2 antibodies by detecting the presence of a HER2/HER3 and/or HER2/HER1 protein complex or for HER2 phosphorylation in a sample of tumor cells. Patients suffering from a tumor comprising HER/2/HER1 and/or HER2/HER3 heterodimers and/or HER2 phosphorylation are treated with anti-HER2 antibodies, such as rhuMAb 2C4.
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公开(公告)号：EP2943508A2
公开(公告)日：2015-11-18
申请号：EP14700281.0
申请日：2014-01-10
发明人： BAUSS, Frieder , BOSSENMAIER, Birgit , FRIESS, Thomas , GERDES, Christian , HASMANN, Max , THOMAS, Marlene , WEISSER, Martin
IPC分类号： C07K16/28 , C07K16/32 , A61P35/00 , A61K39/395
摘要： The present invention relates to the combination therapy of anti-HER3 antibodies with certain anti-HER antibodies.
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公开(公告)号：EP1585966B8
公开(公告)日：2012-03-07
申请号：EP03755724.6
申请日：2003-07-11
发明人： KOLL, Hans , BOSSENMAIER, Birgit , MÜLLER, Hans-Joachim , SLIWKOWSKI, Mark, X. , KELSEY, Stephen, Michael
IPC分类号： A61K39/395
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/24 , G01N33/57492 , G01N2333/485 , G01N2333/71 , G01N2800/52
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6.发明公开
公开(公告)号：EP1848713A2
公开(公告)日：2007-10-31
申请号：EP05816600.0
申请日：2005-11-21
发明人： BOSSENMAIER, Birgit , FRIEBE, Walter-Gunar , HOFFMANN, Eike , VON HIRSCHHEYDT, Thomas , VOSS, Edgar
IPC分类号： C07D413/14
CPC分类号： C07D413/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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公开(公告)号：EP2917243A1
公开(公告)日：2015-09-16
申请号：EP13811131.5
申请日：2013-11-06
发明人： BOSSENMAIER, Birgit , CASAGOLDA VALLRIBERA, David , GEORGES, Guy , GERG, Michael , NIEDERFELLNER, Gerhard , SCHOLZ, Christian , SCHRAEML, Michael
IPC分类号： C07K16/32 , A61K47/48 , C07K14/195 , C07K14/705
CPC分类号： C07K16/2863 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6855 , C07K14/195 , C07K14/71 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/70 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00 , C07K2319/55 , C07K2319/70
摘要： The invention relates to anti-HER3 antigen binding proteins, e.g. anti-HER3 antibodies, that bind to the beta-hairpin of HER3, methods for selecting these antigen binding proteins, their preparation and use as medicament.
摘要翻译： 本发明涉及抗HER3抗原结合蛋白，例如 抗HER3抗体，其结合HER3的β-发夹，选择这些抗原结合蛋白的方法，其制备和用作药物。
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8.发明公开
公开(公告)号：EP2470206A1
公开(公告)日：2012-07-04
申请号：EP10749787.7
申请日：2010-08-26
发明人： BOSSENMAIER, Birgit , FERTIG, Georg , KRELL, Hans-Willi , LAMMERS, Reiner , LIFKE, Alexander , NIEDERFELLNER, Gerhard
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： The present disclosure relates to antibodies against human CDCPl binding to the same epitope as CUB4 (Deposition No. DSM ACC2551) for the treatment of cancer.
摘要翻译： 本发明涉及抗CDCP1与CUB4（沉积号DSM ACC2551）相同表位的抗体用于治疗癌症的抗体。
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9.发明公开
公开(公告)号：EP1758897A1
公开(公告)日：2007-03-07
申请号：EP05779891.0
申请日：2005-03-31
IPC分类号： C07D413/14 , A61K31/422
CPC分类号： C07D413/14
摘要： Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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公开(公告)号：EP1761525B1
公开(公告)日：2008-07-23
申请号：EP05750944.0
申请日：2005-05-24
发明人： BOSSENMAIER, Birgit , FRIEBE, Walter-Gunar , FRIESS, Thomas , KLING, Lothar , REIFF, Ulrike , VOSS, Edgar
IPC分类号： C07D413/12 , A61K31/422 , A61P35/00
CPC分类号： C07D413/12
摘要： Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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