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1.发明公开SEQUENCE NUCLEOTIDIQUE CODANT POUR UNE FLAVINE MONO-OXGYNASE, PROTEINE CORRESPONDANTE ET LEURS APPLICATIONS DANS LES DOMAINES DU DIAGNOSTIC ET DE LA THERAPIE 失效核苷酸拟用作FLAVINMONOOXYGENASE码，相应的蛋白质及其用途的诊断与治疗
公开(公告)号：EP0941341A1
公开(公告)日：1999-09-15
申请号：EP97950244.0
申请日：1997-12-05
IPC分类号： C12N15 , A61K36 , A61K38 , A61K45 , A61P1 , A61P9 , A61P25 , C07K16 , C12N1 , C12N5 , C12N9 , C12P21 , C12Q1 , A61K48
CPC分类号： C12N9/0073 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N2799/021 , C12Q1/6883 , C12Q2600/156
摘要： The invention concerns in particular the human flavin-containing monooxygenase 2 (hFMO2), and another human enzyme of the FMO, hFMOx family, their nucleotide and polypeptide sequences. The invention also concerns vectors for cloning and/or expression containing said nucleotide sequences and cells transformed by these vectors and method for preparing said polypeptides. The invention further concerns methods for selecting compounds and of diagnosing predisposition to pathologies and/or deficiencies related to FMO's and pharmaceutical compositions containing said compounds for treating and/or preventing these pathologies.
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2.发明授权UTILISATION DE PEPTIDES ANALOGUES DE LA THYMULINE (PAT) POUR LA FABRICATION DE MEDICAMENTS CONTRE LA DOULEUR 有权THYMULINÄHNLICHEN肽疼痛部件的生产中使用
公开(公告)号：EP1450843B1
公开(公告)日：2006-08-02
申请号：EP02800641.9
申请日：2002-10-08
发明人： DARDENNE, Mireille , PLEAU, Jean-Marie , BACH, Jean-François , SAADE, Nayef , SAFIEH-GARABEDIAN, Bared, c/o Geminex
CPC分类号： A61K38/08
摘要： The invention concerns the use of thymulin-like peptides inactive with respect to the immune system and having a pain-relieving activity, for making a medicine for treating pain.
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3.发明公开ASSOCIATION MEDICAMENTEUSE UTILE POUR LA TRANSFECTION ET L'EXPRESSION IN VIVO D'EXOGENES 失效医药组合物中的转染和外源性的体内表达
公开(公告)号：EP0809516A1
公开(公告)日：1997-12-03
申请号：EP96903080.0
申请日：1996-02-12
发明人： BACH, Jean-François , CHATENOUD, Lucienne , HADDADA, Hedi , LEE, Martin , PERRICAUDET, Michel , WEBB, Michelle
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343
摘要： A medicinal combination of at least one immunosuppressive agent and at least one recombinant adenovirus with a genome that includes a first recombinant DNA containing a therapeutic gene, and a second recombinant DNA containing an immunoprotective gene, for consecutive, intermittent and/or simultaneous use in in vivo and/or ex vivo exogenic transfections.
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4.发明授权GENE IMPLIQUE DANS LE CADASIL, METHODE DE DIAGNOSTIC ET APPLICATION THERAPEUTIQUE 失效在相关GEN CADASIL，诊断方法和治疗用途
公开(公告)号：EP0915973B1
公开(公告)日：2009-07-01
申请号：EP97936721.6
申请日：1997-07-31
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE, HOPITAUX DE PARIS
IPC分类号： C12N15/12 , C07K14/705 , C12Q1/68 , G01N33/566 , G01N33/50 , C07K16/28 , A61K31/70 , A61K39/395
CPC分类号： C07K14/70567 , A61K38/00
摘要： The invention concerns the Notch3 gene and the corresponding protein which are involved in CADASIL. The invention concerns in particular the methods for demonstrating mutations in this gene which are linked with risks of CADASIL outbreak. The invention also concerns models and products for treating CADASIL and related diseases.
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5.发明授权SEQUENCE NUCLEOTIDIQUE CODANT POUR UNE FLAVINE MONO-OXGYNASE, PROTEINE CORRESPONDANTE ET LEURS APPLICATIONS DANS LES DOMAINES DU DIAGNOSTIC ET DE LA THERAPIE 失效核苷酸拟用作FLAVINMONOOXYGENASE码，相应的蛋白质及其用途的诊断与治疗
公开(公告)号：EP0941341B1
公开(公告)日：2007-01-24
申请号：EP97950244.0
申请日：1997-12-05
申请人： Serono Genetics Institute S.A. , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： C12N15/86 , C12N15/11 , C12N9/02 , C12N5/10 , C12Q1/26 , C12Q1/68 , C07K16/40 , A61K38/44 , A61K39/395 , A61K48/00 , G01N33/50 , G01N33/573
CPC分类号： C12N9/0073 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N2799/021 , C12Q1/6883 , C12Q2600/156
摘要： The invention concerns in particular the human flavin-containing monooxygenase 2 (hFMO2), and another human enzyme of the FMO, hFMOx family, their nucleotide and polypeptide sequences. The invention also concerns vectors for cloning and/or expression containing said nucleotide sequences and cells transformed by these vectors and method for preparing said polypeptides. The invention further concerns methods for selecting compounds and of diagnosing predisposition to pathologies and/or deficiencies related to FMO's and pharmaceutical compositions containing said compounds for treating and/or preventing these pathologies.
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6.发明授权ASSOCIATION MEDICAMENTEUSE UTILE POUR LA TRANSFECTION ET L'EXPRESSION IN VIVO D'EXOGENES 失效医药组合物中的转染和外源性的体内表达
公开(公告)号：EP0809516B1
公开(公告)日：2001-08-22
申请号：EP96903080.8
申请日：1996-02-12
发明人： BACH, Jean-François , CHATENOUD, Lucienne , HADDADA, Hedi , LEE, Martin , PERRICAUDET, Michel , WEBB, Michelle
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343
摘要： A medicinal combination of at least one immunosuppressive agent and at least one recombinant adenovirus with a genome that includes a first recombinant DNA containing a therapeutic gene, and a second recombinant DNA containing an immunoprotective gene, for consecutive, intermittent and/or simultaneous use in in vivo and/or ex vivo exogenic transfections.
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7.发明公开GENE IMPLIQUE DANS LE CADASIL, METHODE DE DIAGNOSTIC ET APPLICATION THERAPEUTIQUE 失效在相关GEN CADASIL，诊断方法和治疗用途
公开(公告)号：EP0915973A1
公开(公告)日：1999-05-19
申请号：EP97936721.0
申请日：1997-07-31
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE, HOPITAUX DE PARIS
IPC分类号： G01N33 , A61K31 , A61K38 , A61K39 , A61K48 , A61P9 , A61P25 , C07K14 , C07K16 , C12N1 , C12N5 , C12N15 , C12P21 , C12Q1
CPC分类号： C07K14/70567 , A61K38/00
摘要： The invention concerns the Notch3 gene and the corresponding protein which are involved in CADASIL. The invention concerns in particular the methods for demonstrating mutations in this gene which are linked with risks of CADASIL outbreak. The invention also concerns models and products for treating CADASIL and related diseases.
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