公开(公告)号：EP1649028A2

公开(公告)日：2006-04-26

申请号：EP04779179.3

申请日：2004-07-26

申请人： GENVEC, INC.

发明人： GALL, Jason G. D. ,  WICKHAM, Thomas J. ,  ENRIGHT, William, J. ,  BROUGH, Douglas, E. ,  ZUBER, Mohammed ,  KING, C., Richter

IPC分类号： C12N15/861 ,  A61K39/235

CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K2039/5256 ,  C07K2319/00 ,  C12N2710/10343 ,  C12N2710/10345

摘要： The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal a non-subgroup C adenoviral vector comprising an adenoviral fiber protein having an amino acid sequence comprising about 80 % or more identity to an amino acid sequence encoding a subgroup C adenoviral fiber protein. The adenoviral vector further comprises a nucleic acid sequence encoding an antigen which is expressed in the mammal to induce an immune response. The invention further comprises a method of producing an adenoviral vector, and a composition comprising a serotype 41 or a serotype 35 adenoviral vector and a carrier. The invention also provides an adenoviral vector comprising a nucleic acid sequence encoding an adenoviral pIX protein operably linked to a heterologous expression control sequence, as well as a method of enhancing the stability and/or packaging capacity of an adenoviral vector.

公开(公告)号：EP1784493A2

公开(公告)日：2007-05-16

申请号：EP05808866.7

申请日：2005-08-30

申请人： The Government of the United States of America as Represented by The Department of Health and Human Services ,  GenVec, Inc.

发明人： NABEL, Gary J. ,  CHENG, Cheng ,  GALL, Jason G. D. ,  WICKHAM, Thomas J., EMD Lexigen Bedford Campus

IPC分类号： C12N15/861 ,  A61K39/00

CPC分类号： C12N15/86 ,  A61K39/00 ,  C12N2710/10343 ,  Y02A50/412

摘要： The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal an adenoviral vector comprising (a) a subgroup C fiber protein wherein a native coxsackievirus and adenovirus receptor (CAR)-binding site is disrupted, (b) a subgroup C penton base protein wherein a native integrin-binding site is disrupted, and (c) a nucleic acid sequence encoding at least one antigen derived from an infectious agent other than an adenovirus which is expressed in the mammal to induce an immune response.