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公开(公告)号：EP2061604A2
公开(公告)日：2009-05-27
申请号：EP07802759.6
申请日：2007-08-21
申请人： Glaxo Group Limited
发明人： ANDERSON, Gregor, John, McLennan , CROSBY, Gary, Thomas , KELLY, Andrew, Michael , TEUCHER, Mark, Digby , WEST, James, Anthony
CPC分类号： A61M15/009 , A61M15/0025 , A61M15/0075 , A61M15/0081 , A61M15/0096 , A61M2205/276 , A61M2205/8281 , B65D83/16
摘要： There is provided a drug dispenser device comprising a housing; extending from the housing, an outlet for insertion into a body cavity of a patient; provided to the housing and moveable with respect thereto, a drug discharge device having a longitudinal axis and comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from the container for discharge of the drug formulation to the outlet; connecting to the drug discharge device, a container collar; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device, a transfer element, the transfer element including an actuating portion; provided to the housing, at least one finger operable member moveable to apply a force to the actuating portion of the transfer element to move the transfer element along the longitudinal axis in a first direction; linking the container collar with the transfer element, a biasing mechanism to store biasing energy on moving the transfer element along the longitudinal axis in the first direction; and provided to the container collar, a pre-load mechanism to prevent transfer of the biasing energy to the container collar to move the drug discharge device along the longitudinal axis in the first direction to actuate the discharge mechanism until a pre-determined threshold force is overcome.
摘要翻译： 提供了一种药物分配器装置（1），其包括从壳体延伸的壳体（10a，10b，12），用于插入患者的体腔中的出口（16） 所述药物排出装置具有纵向轴线并且包括用于储存待分配的药物制剂的容器，排出机构和从容器排出药物制剂到排出口的排出通道 ; 连接到药物排出装置，容器套环; 连接到所述容器套环并且能够沿着所述药物排放装置的纵向轴线相对于所述容器套环移动;传递元件，所述传递元件包括致动部分; 提供给外壳的至少一个手指（20a，20b）可操作构件可移动以向传递元件的致动部分施加力以沿第一方向沿着纵向轴线移动传递元件，将容器套环与传递件 元件，偏置机构，用于在沿第一方向沿纵向轴线移动传输元件时存储偏置能量; 并向容器套环提供预加载机构，以防止偏置能量传递至容器套环，以沿第一方向沿纵向轴线移动药物排放装置，以致动排放机构，直到预定阈值力为 克服。
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公开(公告)号：EP2068983A1
公开(公告)日：2009-06-17
申请号：EP07819960.1
申请日：2007-08-21
申请人： Glaxo Group Limited
发明人： ANDERSON, Gregor, John, McLennan , BURGESS, Penelope, Ann , CROSBY, Gary, Thomas , FAIRBROTHER, Tristan , FARR, Philip, William
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M15/0021
摘要： An actuator for an inhaler for delivering drug by inhalation, comprising: a housing (11; 111 ) for receiving a canister (5; 106) which comprises a body (7; 107) which includes a base and a head and defines a chamber for containing drug, and a valve stem (8; 108) which extends from the body (7; 107) and from which drug is in use delivered on actuation of the canister (5; 106); an outlet (13; 105) through which a user in use inhales; and a nozzle (4; 104) which provides for delivery of drug through the outlet (13; 105); wherein the outlet (105) includes at least one air flow path (122) which provides for a substantially annular air flow at an inner peripheral surface of the outlet (105) on inhalation by the user through the outlet (105), such as to provide a sheathing air flow to an aerosol spray when delivered from the nozzle (104).
摘要翻译： 一种用于通过吸入来输送药物的吸入器的致动器，包括：用于接收罐（5; 106）的壳体（11; 111），所述罐包括主体（7; 107），所述主体包括基座和头部， 以及从所述主体（7; 107）延伸出的阀杆（8; 108），并且在致动所述罐（5; 106）时输送所述药物，使用所述药物; 出口（13; 105），使用者通过该出口吸入; 和提供通过出口（13; 105）输送药物的喷嘴（4; 104）; 其中所述出口（105）包括至少一个空气流动路径（122），所述至少一个空气流动路径在用户通过所述出口（105）吸入时在所述出口（105）的内周表面处提供基本环形的空气流动，例如 当从喷嘴（104）输送时提供鞘气流到气溶胶喷雾器。
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公开(公告)号：EP1962932A2
公开(公告)日：2008-09-03
申请号：EP06820486.6
申请日：2006-12-11
申请人： GLAXO GROUP LIMITED
发明人： ANDERSON, Gregor, John, McLennan , DAVIES, Michael, Birsha , HAILEY, Mark, Andrew , PALMER, Mark, Gregory , WALKER, Richard, Ian
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0026 , A61M15/0043 , A61M15/0051 , A61M15/0055 , A61M15/007 , A61M15/0075 , A61M2202/064 , A61M2205/12
摘要： A medicament dispenser device suitable for the delivery of medicament powder from an open blister pocket of at least one blister pack, the dispenser device comprises (a) a housing; (b) provided to the housing, an air inlet; (c) enclosed by the housing, a dispensing mechanism for the dispensing of medicament powder from an open blister pocket of at least one blister pack receivable thereby; and (d) associated with the dispensing mechanism and in communication with said air inlet, a manifold comprising (i) a body, (ii) the body defining a chimney having a chimney inlet and a chimney exit for directing airflow from the chimney inlet to the chimney exit; (iii) the body further defining a chamber having a chamber inlet and a chamber exit, (iv) wherein the chimney exit and the chamber inlet lie side-by-side each other such that when the open blister pocket of the blister pack is positioned adjacent thereto the airflow will be directed from the chimney exit to the chamber inlet via the open blister pocket to entrain the medicament powder and enable transport thereof in the airflow from the chamber inlet to the chamber exit, wherein during inhaled use of the dispenser device by a patient, the airflow is drawn into the chimney of the manifold solely through the air inlet provided to the housing.
摘要翻译： 提供了一种用于从至少一个泡罩包装（400a，b）的开口泡罩袋（404a，b）输送药物粉末的药物分配器装置。 分配器装置包括具有空气入口（470）的壳体（420）; 由外壳封闭的分配机构（440,448a，b），用于从开口泡罩袋中分配药物粉末; 并且与分配机构相关联并且与空气入口连通，歧管（450）。 所述歧管包括主体，所述主体限定具有烟囱入口（453）和烟囱出口（454a，b）的烟囱（452），烟囱出口用于将气流（483）从所述烟囱入口引导至所述烟囱出口; 所述主体进一步限定具有腔室入口（473a，b）和腔室出口（474）的腔室（460），其中所述烟囱出口和所述腔室入口彼此并排设置，使得当所述开口泡罩袋 所述泡罩包装定位在其附近，所述气流可以从烟囱出口通过敞开的泡罩袋引导至腔室入口，以夹带所述药物粉末并使其能够运输。 在使用中，气流仅通过提供给壳体的进气口被吸入歧管的烟囱中。
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公开(公告)号：EP1144272B1
公开(公告)日：2005-08-17
申请号：EP00915150.7
申请日：2000-02-23
申请人： GLAXO GROUP LIMITED
发明人： ANDERSON, Gregor, John, McLennan , HAILEY, Mark, Andrew , RUSSELL, David, Joseph , GODFREY, James, William
IPC分类号： B65D83/00
摘要： There is provided a valve for an aerosol container. The valve comprises a valve body (1), within the valve body (1), a sealing ring (112) and receivable by the sealing ring (112), a valve stem (108) having a dispensing passage (10, 11). The valve stem (108) is slidably movable within the sealing ring (112) from a valve-closed position to a valve-open position in which the interior of the valve body is in communication with the dispensing passage (10, 11). The sealing ring (112) is shaped such as to reduce the contact area between the sealing ring (112) and the valve stem (108). Preferably, the valve is a metering valve.
摘要翻译： 提供了用于气溶胶容器的阀。 该阀包括在阀体（1）内的阀体（1），密封环（112）并且可由密封环（112）接收，阀杆（108）具有分配通道（10,11）。 阀杆（108）可在密封环（112）内从阀关闭位置滑动到阀开启位置，其中阀体的内部与分配通道（10,11）连通。 密封环（112）成形为减小密封环（112）和阀杆（108）之间的接触面积。 优选地，该阀是计量阀。
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公开(公告)号：EP1115442A1
公开(公告)日：2001-07-18
申请号：EP99947413.3
申请日：1999-09-23
申请人： GLAXO GROUP LIMITED
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0023 , A61M15/0071
摘要： There is provided an inhalation device suitable for dispensing medicament, particularly medicament for use in the treatment of respiratory disorders. The device comprises a body; a medicament carrier, locatable within said body; a mouthpiece, reversibly movable from a storage position wherein said mouthpiece is within the body to an in-use position wherein a portion of the mouthpiece protrudes from the body and wherein the mouthpiece is in communication with the medicament carrier to allow passage of medicament therebetween; and a mouthpiece actuator coupled to the mouthpiece such that actuation of the mouthpiece actuator moves the mouthpiece towards said storage position and deactuation of the mouthpiece actuator moves the mouthpiece towards the in-use position. The body is shaped to be holdable in one hand and the mouthpiece actuator is actuable in response to a motion of the thumb on the same hand.
摘要翻译： 提供了一种适用于分配药物的吸入装置，特别是用于治疗呼吸障碍的药物。 该装置包括主体; 可位于所述主体内的药物载体; 嘴件，所述嘴件可从所述嘴件位于所述主体内的存储位置可逆地移动至使用位置，在所述使用位置中，所述嘴件的一部分从所述主体突出，并且其中所述嘴件与所述药剂载体连通以允许药剂在其间通过; 以及咬嘴致动器，其耦合到所述咬嘴，使得所述咬嘴致动器的致动使所述咬嘴朝向所述存储位置移动，并且所述咬嘴致动器的解除致使所述咬嘴朝向所述使用位置移动。 身体成形为可以一只手握住，并且响应于同一只手上的拇指运动，咬嘴致动器可致动。
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公开(公告)号：EP1115441A1
公开(公告)日：2001-07-18
申请号：EP99947412.5
申请日：1999-09-23
申请人： GLAXO GROUP LIMITED
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0023 , A61M15/0071
摘要： There is provided an inhalation device suitable for dispensing medicament, particularly medicament for use in the treatment of respiratory disorders. The device comprises a body; a medicament carrier, locatable within said body; a mouthpiece, reversibly movable from a storage position wherein said mouthpiece is within the body to an in-use position wherein a portion of the mouthpiece protrudes from the body and wherein the mouthpiece is in communication with the medicament carrier to allow passage of medicament therebetween; and a mouthpiece actuator, movable relative to the body, and coupled to the mouthpiece such that movement of the mouthpiece actuator in a first direction moves the mouthpiece towards said storage position and movement of the mouthpiece actuator in an opposing direction moves the mouthpiece towards the in-use position. The device comprises no biassing means acting on the mouthpiece actuator.
摘要翻译： 提供了适于分配药物的吸入装置，特别是用于治疗呼吸系统疾病的药物。 该装置包括一个主体; 药剂载体，可定位在所述体内; 一个接口装置，其可从储存位置可逆地移动，其中所述接口件在体内至使用位置，其中接口的一部分从主体突出，并且其中接口与药物载体连通以允许药物在其间通过; 以及接口致动器，其可相对于主体移动并且联接到接口管，使得接口致动器沿第一方向的运动使接口朝向所述存储位置移动，并且接口致动器沿相反方向的运动使接口朝向入口 - 使用位置。 该装置不包括作用在吹嘴致动器上的偏压装置。
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公开(公告)号：EP2068983B1
公开(公告)日：2014-07-23
申请号：EP07819960.1
申请日：2007-08-21
申请人： Glaxo Group Limited
发明人： ANDERSON, Gregor, John, McLennan , BURGESS, Penelope, Ann , CROSBY, Gary, Thomas , FAIRBROTHER, Tristan , FARR, Philip, William
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M15/0021
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公开(公告)号：EP2056909A1
公开(公告)日：2009-05-13
申请号：EP07788505.1
申请日：2007-08-21
申请人： Glaxo Group Limited
发明人： ANDERSON, Gregor, John, McLennan , BURGESS, Penelope, Ann , CROSBY, Gary, Thomas , FAIRBROTHER, Tristan , FARR, Philip William
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M15/0025 , A61M15/0086 , A61M2206/10 , A61M2209/06
摘要： An actuator for an inhaler for delivering drug by inhalation, comprising: a housing (11; 111 ) for receiving a canister (5; 106) which comprises a body (7; 107) which includes a base and a head and defines a chamber for containing drug, and a valve stem (8; 108) which extends from the body (7; 107) and from which drug is in use delivered on actuation of the canister (5; 106); an outlet (13; 105) through which a user in use inhales; and a nozzle assembly (4; 104) which provides for delivery of drug through the outlet (13; 105), wherein the nozzle assembly (4; 104) comprises a nozzle block (17; 127) for receiving the valve stem (8; 108) of the canister (5; 106) and, as a separately-formed component, a nozzle outlet (19; 121 ) which is fluidly connected to the nozzle block (17; 127) and includes an outlet orifice (41; 123) from which drug is in use delivered.
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公开(公告)号：EP2037861A2
公开(公告)日：2009-03-25
申请号：EP07787129.1
申请日：2007-07-05
申请人： Glaxo Group Limited
IPC分类号： A61J7/02
摘要： A counter (or recorder) for a pill dispenser (24), the counter (or recorder) comprising two relatively moveable chassis components (50, 52) forming part of a pill dispensement mechanism (21), a pill delivery or dispensement channel (32) for a pill or tablet (28) to pass through for dispensement and a counting (or recording) mechanism. The counting (or recording) mechanism comprises one or more actuation indicators (11), a ratchet pawl (14) for incrementally advancing a first (12) of the one or more actuation indicators (11) and a drive mechanism (16) for activating the ratchet pawl (14). The ratchet pawl (14) is mounted to a first of the two chassis components (50, 52). The drive mechanism (16) is mounted to the second of the two chassis components (50, 52). By this arrangement, by moving the two chassis components (50, 52) relative to each other, the drive mechanism (16) is moved relative to the ratchet pawl (14) and the pill dispensement mechanism (21) is actuated. The drive mechanism (16) is connected to a pill detect feature (18) that can move between a positive dispensement position and a negative dispensement position if the channel (32) is clear, the negative dispensement position being such that at least a part of the pill detect feature (18) is positioned within or blocking the pill delivery or dispensement channel (32), whereby the non-presence of a pill (28) within the channel (32) for dispensement, and therefore a failed dispensement, is confirmed. The movement from the positive dispensement position to the negative dispensement position prevents the drive mechanism (16) from activating the ratchet pawl (14) as the drive mechanism (16) moves relative to the ratchet pawl (16).
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公开(公告)号：EP1159020B1
公开(公告)日：2005-02-16
申请号：EP00909231.3
申请日：2000-02-23
申请人： GLAXO GROUP LIMITED
CPC分类号： A61M16/0057 , A61M11/00 , A61M15/00 , A61M15/0066 , A61M15/008 , A61M15/009 , A61M15/0091 , A61M15/0096 , A61M2016/0024 , A61M2205/33 , A61M2205/50 , A61M2205/52
摘要： There is provided a system for the delivery of inhalable medicament comprising a monitor (40) for monitoring the breath cycle of a patient, a medicament container (2) having a release mechanism (4, 5) for releasing inhalable medicament therefrom, and an actuator (50) for actuating said release mechanism, the actuator (50) being actuable in response to a signal from the monitor (40). The monitor (40) provides the signal at a trigger point which is coupled to the end of the exhalation part of the breath cycle.
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