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1.发明公开SYSTEMS AND METHODS TO FACILITATE MULTIPLE ORDER COMBINATORIAL CHEMICAL PROCESSES 审中-公开系统和方法，以促进多阶组合化学过程的LOT
公开(公告)号：EP1235765A2
公开(公告)日：2002-09-04
申请号：EP00982413.7
申请日：2000-12-05
申请人： GLAXO GROUP LIMITED
CPC分类号： C40B30/04 , B01J2219/00572 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01J2219/00738 , C07B2200/11 , C07C237/22 , C40B70/00 , G01N33/6845
摘要： A method to screen for reactive chemicals comprises the steps of configuring a set of constructs such that each construct of the set includes a pairwise combination of a chemical entity (A1-Ai) of a chemical library (A) and a chemical entity (B1-Bj) of a chemical library (B). The set of constructs includes essentially every possible pairwise combination of the chemical entities (A1-Ai) of the chemical library (A) and the chemical entities (B1-Bj) of the chemical library (B). The constructs are exposed to a given set of conditions to facilitate reactions or interactions between the chemical entity (A1-Ai) and the chemical entity (B1-Bj) of each construct. The constructs are screened to identify any reactions or interactions, and the chemical entity (A1-Ai) and the chemical entity (B1-Bj) of any constructs where reactions or interactions occurred are identified.
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公开(公告)号：EP1169123A1
公开(公告)日：2002-01-09
申请号：EP00921748.0
申请日：2000-04-05
申请人： GLAXO GROUP LIMITED
CPC分类号： B01J19/0046 , B01J2219/00454 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00545 , B01J2219/00554 , B01J2219/00563 , B01J2219/00585 , B01J2219/00592 , B01J2219/00596 , B01J2219/0072 , C07B2200/11 , C40B50/14 , C40B70/00
摘要： The invention provides an exemplary chemical library which includes a plurality of constructs which are separable into physically distinct groups. The constructs in each group have at least one common physical characteristic, which is physically distinct from the physical characteristics of the constructs in all other groups. The physical characteristics represent the manner by which the group is testable. The constructs are especially bead-linker-tag-ligand systems. The physical characteristics are especially the size or density of the bead. Preferably, the physical characteristic of a bead is indicative of the type of linker used, which provides easy recognition of constructs suitable for use in specific assays.
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