公开(公告)号：EP1277055B1

公开(公告)日：2008-04-30

申请号：EP01913879.1

申请日：2001-03-14

申请人： Bioref GmbH

发明人： STAAB, Hans-Jürgen

IPC分类号： G01N33/543

CPC分类号： G01N33/54366 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00533 ,  B01J2219/00542 ,  B01J2219/00547 ,  B01J2219/00563 ,  B01J2219/00565 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00722 ,  B01J2219/0074 ,  B01J2219/00743 ,  C40B40/06 ,  C40B60/14 ,  C40B70/00

摘要： A biochip for diagnostic use comprises a sample support consisting of a solid matrix, to whose surface the sample material to be analysed, originating from a biological organism, is bonded.

公开(公告)号：EP1846249A2

公开(公告)日：2007-10-24

申请号：EP06717793.1

申请日：2006-01-10

申请人： Bioforce Nanosciences, Inc.

发明人： XU, Juntao ,  MOSHER, Curtis ,  LYNCH, Michael

IPC分类号： B41M5/00 ,  C12N11/02

CPC分类号： H01L23/544 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00542 ,  B01J2219/00554 ,  B01J2219/0056 ,  B01J2219/00563 ,  B01L3/5085 ,  B01L9/50 ,  B01L2300/0819 ,  B82Y30/00 ,  H01L2924/0002 ,  H01L2924/09701 ,  H01L2924/00

摘要： The present invention provides an indexed support substrate. The support substrate comprises at least one set of indexing features that are distinguishable from one another and from the surrounding substrate. The support substrate also comprises a set of useful domains. The indexing features are positioned on the substrate in such a way as to correspond to the useful domains in an identifying fashion.

公开(公告)号：EP1450960A1

公开(公告)日：2004-09-01

申请号：EP02790431.7

申请日：2002-11-25

申请人： Miltenyi Biotec GmbH

发明人： MILTENYI, Stefan ,  KOHLER, Matthias

IPC分类号： B03C1/00 ,  B03C1/025 ,  B03C1/30 ,  G01N33/543 ,  C12Q1/68

CPC分类号： C12Q1/6806 ,  B01J2219/005 ,  B01J2219/00563 ,  B01J2219/00722 ,  B01L3/50255 ,  B03C1/002 ,  B03C1/025 ,  B03C1/30 ,  C12Q1/6834 ,  C12Q2563/143

摘要： The invention provides an apparatus and method for modification of magneticallyimmobilized biomolecules, particularly for temperature-controlled modifications.

公开(公告)号：EP0822861B1

公开(公告)日：2003-11-26

申请号：EP96916437.5

申请日：1996-04-25

申请人： Discovery Partners International, Inc.

发明人： NOVA, Michael, P. ,  SENYEI, Andrew, E. ,  PARANDOOSH, Zahra ,  DAVID, Gary, S. ,  XIAO, Xiao-Yi

IPC分类号： B01L3/14 ,  G01N35/00 ,  C07K1/04 ,  G01N33/48 ,  G01N33/58 ,  G01N33/543 ,  B01J19/00

CPC分类号： C40B30/04 ,  B01J19/0046 ,  B01J2219/00295 ,  B01J2219/00299 ,  B01J2219/00308 ,  B01J2219/00333 ,  B01J2219/00344 ,  B01J2219/00461 ,  B01J2219/00463 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/0054 ,  B01J2219/00542 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00551 ,  B01J2219/0056 ,  B01J2219/00563 ,  B01J2219/00567 ,  B01J2219/00569 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2300/0609 ,  B82Y10/00 ,  C07K1/00 ,  C07K1/04 ,  C07K1/047 ,  C40B40/06 ,  C40B40/10 ,  C40B60/08 ,  C40B60/14 ,  C40B70/00 ,  G01N35/00732 ,  G01N35/00871 ,  G01N2015/149 ,  G01N2035/00782 ,  G11C13/0014 ,  G11C13/0019 ,  G11C13/025

摘要： Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for electronically tagging molecules, biological particles and matrix support materials, immuoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.

公开(公告)号：EP1169123A1

公开(公告)日：2002-01-09

申请号：EP00921748.0

申请日：2000-04-05

申请人： GLAXO GROUP LIMITED

发明人： GEYSEN, H. Mario,Glaxo Wellcome Inc.

IPC分类号： B01J19/00 ,  C07B61/00

CPC分类号： B01J19/0046 ,  B01J2219/00454 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/0054 ,  B01J2219/00545 ,  B01J2219/00554 ,  B01J2219/00563 ,  B01J2219/00585 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/0072 ,  C07B2200/11 ,  C40B50/14 ,  C40B70/00

摘要： The invention provides an exemplary chemical library which includes a plurality of constructs which are separable into physically distinct groups. The constructs in each group have at least one common physical characteristic, which is physically distinct from the physical characteristics of the constructs in all other groups. The physical characteristics represent the manner by which the group is testable. The constructs are especially bead-linker-tag-ligand systems. The physical characteristics are especially the size or density of the bead. Preferably, the physical characteristic of a bead is indicative of the type of linker used, which provides easy recognition of constructs suitable for use in specific assays.

公开(公告)号：EP0822861A1

公开(公告)日：1998-02-11

申请号：EP96916437.0

申请日：1996-04-25

申请人： Irori

发明人： NOVA, Michael, P. ,  SENYEI, Andrew, E. ,  PARANDOOSH, Zahra ,  DAVID, Gary, S. ,  XIAO, Xiao-Yi

IPC分类号： G01N33 ,  B01J19 ,  B01L3 ,  C07B61 ,  C07K1 ,  C07K17 ,  C12N15 ,  C12Q1 ,  G01N35 ,  G01N37 ,  G08C19 ,  G08C23 ,  G11C13 ,  C40B40 ,  C40B60 ,  C40B70 ,  G01N15

CPC分类号： C40B30/04 ,  B01J19/0046 ,  B01J2219/00295 ,  B01J2219/00299 ,  B01J2219/00308 ,  B01J2219/00333 ,  B01J2219/00344 ,  B01J2219/00461 ,  B01J2219/00463 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/0054 ,  B01J2219/00542 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00551 ,  B01J2219/0056 ,  B01J2219/00563 ,  B01J2219/00567 ,  B01J2219/00569 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2300/0609 ,  B82Y10/00 ,  C07K1/00 ,  C07K1/04 ,  C07K1/047 ,  C40B40/06 ,  C40B40/10 ,  C40B60/08 ,  C40B60/14 ,  C40B70/00 ,  G01N35/00732 ,  G01N35/00871 ,  G01N2015/149 ,  G01N2035/00782 ,  G11C13/0014 ,  G11C13/0019 ,  G11C13/025

摘要： Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for electronically tagging molecules, biological particles and matrix support materials, immuoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.

摘要翻译： 提供了具有包含至少一个数据存储单元的具有可远程寻址或可远程编程的记录装置的矩阵材料的具有存储器的组合。 基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。 基质材料可另外包括荧光体或其它发光部分以产生具有记忆的发光基质。 数据存储单元是非易失性反熔丝存储器或易失性存储器，例如EEPROMS，DRAMS或闪存。 通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的 信息。 还提供了基质材料，记忆和连接分子和生物材料的组合。 这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，细胞分选，药物递送，化学修饰和其它用途。 还提供了用于电子标记分子，生物颗粒和基质支持材料的方法，免疫测定，受体结合测定，闪烁亲和测定，非放射性邻近测定和其它方法。

公开(公告)号：EP0604552A1

公开(公告)日：1994-07-06

申请号：EP92920422.0

申请日：1992-09-16

申请人： AFFYMAX TECHNOLOGIES N.V.

发明人： DOWER, William, J. ,  BARRETT, Ronald, W. ,  GALLOP, Mark, A. ,  NEEDELS, Michael, C.

IPC分类号： C12N15 ,  B01J19 ,  C07B61 ,  C07H19 ,  C07H21 ,  C07K1 ,  C07K5 ,  C07K7 ,  C08F8 ,  C08G85 ,  C40B40 ,  C40B60 ,  C40B70

CPC分类号： C07K1/047 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00306 ,  B01J2219/00313 ,  B01J2219/00459 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/00536 ,  B01J2219/00542 ,  B01J2219/00545 ,  B01J2219/00547 ,  B01J2219/00554 ,  B01J2219/00563 ,  B01J2219/00565 ,  B01J2219/00572 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  C07B2200/11 ,  C07H19/10 ,  C07H19/14 ,  C07H21/00 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  C40B70/00 ,  Y10S435/81 ,  Y10T436/143333

摘要： Procédé stochastique général de synthèse d'oligomères au hasard, ce procédé pouvant être utilisé pour synthétiser des composés afin de déterminer des propriétés désirées. L'utilisation d'étiquettes d'identification sur les oligomères facilite l'identification d'oligomères ayant des propriétés désirées.

公开(公告)号：EP3277845A1

公开(公告)日：2018-02-07

申请号：EP16773777.4

申请日：2016-03-24

申请人： Genapsys Inc.

发明人： LAU, Aldrich, N.K. ,  KENNEY, Paul, M. ,  PERSSON, Henrik

IPC分类号： C12Q1/68

CPC分类号： C08G61/128 ,  B01J19/0046 ,  B01J2219/005 ,  B01J2219/00563 ,  B01J2219/00648 ,  C12Q1/6806 ,  C12Q1/6834 ,  C12Q1/6874 ,  C40B50/18 ,  C12Q2535/122 ,  C12Q2563/155

摘要： Provided herein are methods that comprise providing polymer chains comprising a plurality of reactive groups onto the surface of beads and covalent attachment of functionalized biomolecules, such as primers.

公开(公告)号：EP2118345A2

公开(公告)日：2009-11-18

申请号：EP08825901.5

申请日：2008-01-23

申请人： Arrayomics, Inc.

发明人： HEROLD, Christopher D. ,  ROTHWARF, David ,  NGUYEN, Bao

IPC分类号： C40B50/00

CPC分类号： B01J19/0046 ,  B01J2219/00497 ,  B01J2219/00549 ,  B01J2219/00563 ,  B01J2219/00585 ,  B01J2219/00655 ,  B01J2219/00709 ,  C40B40/00 ,  C40B50/00 ,  G01N33/54326 ,  G01N33/54366 ,  G06K19/06187

摘要： Microdevices containing a predetermined preferential axis of magnetization are disposed in an array having discreet regions. Under influence of a magnetic field, the microdevices can have at least twelve discrete orientations, and can advantageously be flipped upside down in place. Microdevices can be coded in a manner that supports a coding space of at least 102, 103, 106 or even 1010 or more choices, and can include one or more chemically reactive sites. The regions can be defined by long and short bars, in which microdevices span gaps between the longer bars, and the shorter bars measure less than 60% of such gaps. Preferred embodiments are also provided to produce microfabricated microdevices for magnetic assembly-based arraying.

公开(公告)号：EP1958128A2

公开(公告)日：2008-08-20

申请号：EP06808770.9

申请日：2006-11-21

申请人： CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED ,  UNIVERSITY OF SOUTHAMPTON

发明人： BLAND, James, Anthony, Charles ,  LLANDRO, Justin ,  ZHELUDEV, Nikolay ,  VAN BELLE, Frieda ,  TRYPINIOTIS, Theodossis ,  KOPPER, Klaus, Peter ,  STEINMULLER, Stephen ,  MITRELIAS, Athanasios

IPC分类号： G06K19/06 ,  B01L3/00 ,  B07C3/16 ,  G01N35/00 ,  B01J19/00

CPC分类号： G06K19/06187 ,  B01J2219/00509 ,  B01J2219/00563 ,  B01L3/502761 ,  B01L3/545 ,  B01L2200/0636 ,  B01L2200/0647 ,  B07C5/3412 ,  B82Y10/00 ,  B82Y25/00 ,  B82Y30/00

摘要： This invention relates to microfluidic apparatus for reading, writing and sorting magnetic tags attached to chemical and biological molecules and other entities. We describe apparatus for separating chemical or biological molecules or moieties each individually attached to a MBM tag miniature multi-bit magnetic tag capable of adopting a plurality of remanent magnetic configurations corresponding to binary information, the apparatus comprising: at least one input for said tagged molecules or moieties; at least two outputs for said tagged molecules or moieties; a microfluidic flow channel incorporating: magnetic readers to read said binary information; magnetic writers to write said binary information; and a switch to direct said tagged molecules or moieties to a selected said output responsive to said binary information.