公开(公告)号：EP1343757B1

公开(公告)日：2007-02-14

申请号：EP01271354.1

申请日：2001-12-20

申请人： GLAXO GROUP LIMITED

发明人： DEMAINE, Derek Anthony, GlaxoSmithKline ,  GIBLIN, Gerard Martin Paul, GlaxoSmithKline ,  HOSKING, Rachel Elizabeth, GlaxoSmithKline ,  INGLIS, Graham George Adam, GlaxoSmithKline ,  LEWELL, Xiao Qing, GlaxoSmithKline ,  MACDONALD, Simon John Fawcett, Glaxo Wellcome plc ,  MASON, Andrew McMurtrie, GlaxoSmithKline ,  SWARBRICK, Martin Edward, GlaxoSmithKline

IPC分类号： C07D209/18 ,  A61P29/00 ,  A61P37/00

CPC分类号： C07D407/04 ,  C07D209/18 ,  C07D409/04

摘要： Compounds of formula (I) or salts or solvates thereof or physiologically functional derivatives thereof are potent binders at the EP4 receptor and are of use in the treatment or prevention of conditions such as a pain, inflammatory, immunological, bone, neurodegenerative or renal disorder.