公开(公告)号：EP1343757B1

公开(公告)日：2007-02-14

申请号：EP01271354.1

申请日：2001-12-20

申请人： GLAXO GROUP LIMITED

发明人： DEMAINE, Derek Anthony, GlaxoSmithKline ,  GIBLIN, Gerard Martin Paul, GlaxoSmithKline ,  HOSKING, Rachel Elizabeth, GlaxoSmithKline ,  INGLIS, Graham George Adam, GlaxoSmithKline ,  LEWELL, Xiao Qing, GlaxoSmithKline ,  MACDONALD, Simon John Fawcett, Glaxo Wellcome plc ,  MASON, Andrew McMurtrie, GlaxoSmithKline ,  SWARBRICK, Martin Edward, GlaxoSmithKline

IPC分类号： C07D209/18 ,  A61P29/00 ,  A61P37/00

CPC分类号： C07D407/04 ,  C07D209/18 ,  C07D409/04

摘要： Compounds of formula (I) or salts or solvates thereof or physiologically functional derivatives thereof are potent binders at the EP4 receptor and are of use in the treatment or prevention of conditions such as a pain, inflammatory, immunological, bone, neurodegenerative or renal disorder.

公开(公告)号：EP1670763A1

公开(公告)日：2006-06-21

申请号：EP04765925.5

申请日：2004-10-06

申请人： GLAXO GROUP LIMITED

发明人： GIBLIN, Gerard Martin Paul, GlaxoSmithKline ,  HALL, Adrian, GlaxoSmithKline ,  HURST, David Nigel, GlaxoSmithKline ,  KILFORD, Ian Reginald, GlaxoSmithKline ,  LEWELL, Xiao Qing, GlaxoSmithKline ,  NAYLOR, Alan, GlaxoSmithKline ,  NOVELLI, Riccardo, GlaxoSmithKline

IPC分类号： C07D213/55 ,  C07D241/24 ,  C07D239/28 ,  C07D237/24 ,  C07D213/64 ,  C07D213/61 ,  C07C63/68 ,  C07C233/54 ,  C07C229/56 ,  C07D401/08 ,  C07D213/00

CPC分类号： C07C65/28 ,  C07C229/56 ,  C07C233/54 ,  C07C2601/10 ,  C07D213/55 ,  C07D213/61 ,  C07D213/64 ,  C07D237/24 ,  C07D239/28 ,  C07D241/24 ,  C07D401/08

摘要： Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, B, Z, R1, R2a, R2b, R8, R9, and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.

摘要翻译： 式（I）化合物或其药学上可接受的衍生物：其中A，B，Z，R1，R2a，R2b，R8，R9和Rx如说明书中所定义，制备这些化合物的方法，药物组合物 包括这些化合物和这些化合物在医药中的用途。