公开(公告)号：EP1363925B8

公开(公告)日：2007-04-25

申请号：EP01271380.6

申请日：2001-12-20

申请人： GLAXO GROUP LIMITED ,  GlaxoSmithKline istrazivacki centar Zagreb d.o.o.

发明人： ANDREOTTI, Daniele, GlaxoSmithKline SpA ,  ARISTA, Luca, GlaxoSmithKline SpA ,  BIONDI, Stefano, GlaxoSmithKline SpA ,  CARDULLO, Francesca, GlaxoSmithKline SpA ,  DAMIANI, Frederica, GlaxoSmithKline SpA ,  LOCIURO, Sergio, GlaxoSmithKline SpA ,  MARCHIORO, Carla, GlaxoSmithKline SpA ,  MERLO, Giancarlo, GlaxoSmithKline SpA ,  MINGARDI, Anna, GlaxoSmithKline SpA ,  NICCOLAI, Daniela, GlaxoSmithKline SpA ,  PAIO, Alfredo, GlaxoSmithKline SpA ,  PIGA, Elisabetta, GlaxoSmithKline SpA ,  POZZAN, Alfonso, GlaxoSmithKline SpA ,  SERI, Catia, GlaxoSmithKline SpA ,  TARSI, Luca, GlaxoSmithKline SpA ,  TERRENI, Silvia, GlaxoSmithKline SpA ,  TIBASCO, Jessica, GlaxoSmithKline SpA ,  CIRACO, Manuela, c/o BPB Italia S.p.A.

IPC分类号： C07H17/08 ,  A61K31/70

CPC分类号： C07H17/08 ,  A61K9/0019 ,  A61K9/2018 ,  Y02P20/55

公开(公告)号：EP1363925B1

公开(公告)日：2006-11-15

申请号：EP01271380.6

申请日：2001-12-20

申请人： GLAXO GROUP LIMITED ,  PLIVA D.D.

发明人： ANDREOTTI, Daniele, GlaxoSmithKline SpA ,  ARISTA, Luca, GlaxoSmithKline SpA ,  BIONDI, Stefano, GlaxoSmithKline SpA ,  CARDULLO, Francesca, GlaxoSmithKline SpA ,  DAMIANI, Frederica, GlaxoSmithKline SpA ,  LOCIURO, Sergio, GlaxoSmithKline SpA ,  MARCHIORO, Carla, GlaxoSmithKline SpA ,  MERLO, Giancarlo, GlaxoSmithKline SpA ,  MINGARDI, Anna, GlaxoSmithKline SpA ,  NICCOLAI, Daniela, GlaxoSmithKline SpA ,  PAIO, Alfredo, GlaxoSmithKline SpA ,  PIGA, Elisabetta, GlaxoSmithKline SpA ,  POZZAN, Alfonso, GlaxoSmithKline SpA ,  SERI, Catia, GlaxoSmithKline SpA ,  TARSI, Luca, GlaxoSmithKline SpA ,  TERRENI, Silvia, GlaxoSmithKline SpA ,  TIBASCO, Jessica, GlaxoSmithKline SpA ,  CIRACO, Manuela, c/o BPB Italia S.p.A.

IPC分类号： C07H17/08 ,  A61K31/70

CPC分类号： C07H17/08 ,  A61K9/0019 ,  A61K9/2018 ,  Y02P20/55

摘要： The present invention relates to 11,12 gamma lactone ketolides of formula (I) wherein R, R , R , R are as defined herein and pharmaceutically acceptable salts and solvates thereof, to process for their preparation and their use in therapy or prophylaxis of systemic or topical bacterial infections in a human or animal body.

摘要翻译： 本发明涉及其中R，R 1，R 2，R 3如本文所定义的式（I）的11,12-内酯酮内酯及其药学上可接受的盐和溶剂合物，以制备其制备方法 以及它们在治疗或预防人或动物体内的全身或局部细菌感染中的用途。