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公开(公告)号：EP1363925B8
公开(公告)日：2007-04-25
申请号：EP01271380.6
申请日：2001-12-20
发明人： ANDREOTTI, Daniele, GlaxoSmithKline SpA , ARISTA, Luca, GlaxoSmithKline SpA , BIONDI, Stefano, GlaxoSmithKline SpA , CARDULLO, Francesca, GlaxoSmithKline SpA , DAMIANI, Frederica, GlaxoSmithKline SpA , LOCIURO, Sergio, GlaxoSmithKline SpA , MARCHIORO, Carla, GlaxoSmithKline SpA , MERLO, Giancarlo, GlaxoSmithKline SpA , MINGARDI, Anna, GlaxoSmithKline SpA , NICCOLAI, Daniela, GlaxoSmithKline SpA , PAIO, Alfredo, GlaxoSmithKline SpA , PIGA, Elisabetta, GlaxoSmithKline SpA , POZZAN, Alfonso, GlaxoSmithKline SpA , SERI, Catia, GlaxoSmithKline SpA , TARSI, Luca, GlaxoSmithKline SpA , TERRENI, Silvia, GlaxoSmithKline SpA , TIBASCO, Jessica, GlaxoSmithKline SpA , CIRACO, Manuela, c/o BPB Italia S.p.A.
CPC分类号： C07H17/08 , A61K9/0019 , A61K9/2018 , Y02P20/55
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2.发明公开COMPOUNDS HAVING AFFINITY FOR THE DOPAMINE D3 RECEPTOR AND USES THEREOF IN MEDICINE 审中-公开连接要AFFINITY多巴胺D3受体及其医学应用
公开(公告)号：EP1773844A1
公开(公告)日：2007-04-18
申请号：EP05760843.2
申请日：2005-06-29
申请人： GLAXO GROUP LIMITED
发明人： BONANOMI, Giorgio, GlaxoSmithKline SpA , CARDULLO, Francesca, GlaxoSmithKline SpA , DAMIANI, Federica, GlaxoSmithKline SpA , GENTILE, Gabriella, GlaxoSmithKline SpA , HAMPRECHT, Dieter, GlaxoSmithKline SpA , MICHELI, Fabrizio, GlaxoSmithKline SpA , TARSI, Luca, GlaxoSmithKline SpA
IPC分类号： C07D498/04 , C07D513/04 , A61K31/55 , A61P25/18 , A61P25/30 , C07D263/00 , C07D223/00 , C07D277/00
CPC分类号： C07D513/04
摘要： Compounds of formula (I) or a salt thereof are disclosed, wherein A, m R1, R2, R3, q, W1, W2, R4 and R5 are as defined in the description. Processes for preparation and uses of the compounds in medicine, for example for the treatment of schizophrenia or drug dependency, are also disclosed.
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公开(公告)号：EP1363925B1
公开(公告)日：2006-11-15
申请号：EP01271380.6
申请日：2001-12-20
申请人： GLAXO GROUP LIMITED , PLIVA D.D.
发明人： ANDREOTTI, Daniele, GlaxoSmithKline SpA , ARISTA, Luca, GlaxoSmithKline SpA , BIONDI, Stefano, GlaxoSmithKline SpA , CARDULLO, Francesca, GlaxoSmithKline SpA , DAMIANI, Frederica, GlaxoSmithKline SpA , LOCIURO, Sergio, GlaxoSmithKline SpA , MARCHIORO, Carla, GlaxoSmithKline SpA , MERLO, Giancarlo, GlaxoSmithKline SpA , MINGARDI, Anna, GlaxoSmithKline SpA , NICCOLAI, Daniela, GlaxoSmithKline SpA , PAIO, Alfredo, GlaxoSmithKline SpA , PIGA, Elisabetta, GlaxoSmithKline SpA , POZZAN, Alfonso, GlaxoSmithKline SpA , SERI, Catia, GlaxoSmithKline SpA , TARSI, Luca, GlaxoSmithKline SpA , TERRENI, Silvia, GlaxoSmithKline SpA , TIBASCO, Jessica, GlaxoSmithKline SpA , CIRACO, Manuela, c/o BPB Italia S.p.A.
CPC分类号： C07H17/08 , A61K9/0019 , A61K9/2018 , Y02P20/55
摘要： The present invention relates to 11,12 gamma lactone ketolides of formula (I) wherein R, R , R , R are as defined herein and pharmaceutically acceptable salts and solvates thereof, to process for their preparation and their use in therapy or prophylaxis of systemic or topical bacterial infections in a human or animal body.
摘要翻译： 本发明涉及其中R，R 1，R 2，R 3如本文所定义的式（I）的11,12-内酯酮内酯及其药学上可接受的盐和溶剂合物，以制备其制备方法 以及它们在治疗或预防人或动物体内的全身或局部细菌感染中的用途。
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公开(公告)号：EP1758890A1
公开(公告)日：2007-03-07
申请号：EP05755576.5
申请日：2005-06-17
申请人： GLAXO GROUP LIMITED
发明人： HAMPRECHT, Dieter, GlaxoSmithKline SpA , MICHELI, Fabrizio, GlaxoSmithKline SpA , TARSI, Luca, GlaxoSmithKline SpA , TEDESCO, Giovanna, GlaxoSmithKline SpA
IPC分类号： C07D401/14 , C07D403/14 , C07D413/14 , A61K31/55 , A61P25/00
CPC分类号： C07D403/14 , C07D401/14 , C07D413/14
摘要： Compounds of formula (I) or a salt thereof are disclosed (I): wherein R1 is pyrazolyl substituted by two or three substituents independently selected from halogen, C1-4alkyl and haloC1-4alkyl; R2 is hydrogen or methyl; and R3 is quinolinyl, oxazolyl or phenyl, each of which is optionally substituted by one or two halogen, C1-4alkyl or haloC1-4alkyl. Processes for preparation and uses of the compounds in medicine, for example for the treatment of schizophrenia or drug dependency, are also disclosed.
摘要翻译： 公开了式（I）的化合物或其盐（I）：其中R 1为被两个或三个独立选自卤素，C 1-4烷基和卤代C 1-4烷基的取代基取代的吡唑基; R2是氢或甲基; 并且R 3是喹啉基，恶唑基或苯基，其各自任选被一个或两个卤素，C 1-4烷基或卤代C 1-4烷基取代。 还公开了该化合物在药物中的制备和用途，例如用于治疗精神分裂症或药物依赖性的方法。
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