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1.发明授权AGENTS USEFUL FOR REDUCING AMYLOID PRECURSOR PROTEIN AND TREATING DEMANTIA AND METHODS OF USE THEREOF 有权用于减少淀粉样前体蛋白和感低的治疗活性成分，和它们的使用方法
公开(公告)号：EP1349858B1
公开(公告)日：2008-08-27
申请号：EP01989211.6
申请日：2001-11-02
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , TorreyPines Therapeutics, Inc.
发明人： GREIG, Nigel, H. , SHAW, Karen, T., Y. , YU, Qiang-Sheng , HOLLOWAY, Harold, W. , UTSUKI, Tada , SONCRANT, Timothy, T. , INGRAM, Donald, S. , BROSSI, Arnold , GIORDANO, Anthony , POWERS, Gordon , DAVIDSON, Diane , STURGESS, Michael
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
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2.发明公开AGENTS USEFUL FOR REDUCING AMYLOID PRECURSOR PROTEIN AND TREATING DEMANTIA AND METHODS OF USE THEREOF 有权用于减少淀粉样前体蛋白和感低的治疗活性成分，和它们的使用方法
公开(公告)号：EP1349858A2
公开(公告)日：2003-10-08
申请号：EP01989211.6
申请日：2001-11-02
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA,as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , Message Pharmaceuticals
发明人： GREIG, Nigel, H. , SHAW, Karen, T., Y. , YU, Qiang-Sheng , HOLLOWAY, Harold, W. , UTSUKI, Tada , SONCRANT, Timothy, T. , INGRAM, Donald, S. , BROSSI, Arnold , GIORDANO, Anthony , POWERS, Gordon , DAVIDSON, Diane , STURGESS, Michael
IPC分类号： C07D487/00
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject taht can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not tocix in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
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