公开(公告)号：EP1670804A2

公开(公告)日：2006-06-21

申请号：EP04786934.2

申请日：2004-09-10

申请人： GPC Biotech AG

发明人： KOUL, Anil ,  KLEBL, Bert ,  MÜLLER, Gerhard ,  MISSIO, Andrea ,  SCHWAB, Wilfried ,  HAFENBRADL, Doris ,  NEUMANN, Lars ,  SOMMER, Marc-Nicola ,  MÜLLER, Stefan ,  HOPPE, Edmund ,  FREISLEBEN, Achim ,  BACKES, Alexander ,  HARTUNG, Christian ,  FELBER, Beatrice ,  ZECH, Birgit ,  ENGKVIST, Ola ,  KERI, György ,  ÖRFI, Laszlo ,  BANHEGYI, Peter ,  GREFF, Zoltan ,  HORVATH, Zoltan ,  VARGA, Zoltan ,  MARKO, Péter ,  PATO, Jànos ,  SZABADKAI, Istvan ,  SZEKELYHIDI, Zsolt ,  WACZEK, Frigyes

IPC分类号： C07D495/04 ,  C07D495/10 ,  C07D493/04 ,  C07D491/04 ,  C07D409/12 ,  C07D333/66 ,  C07D333/68 ,  C07D209/42 ,  A61K31/381 ,  A61P31/04

CPC分类号： C07D409/12 ,  C07D209/42 ,  C07D333/66 ,  C07D333/68 ,  C07D491/04 ,  C07D493/04 ,  C07D495/04 ,  C07D495/10

摘要： Described are heterobicyclic compounds such as 4,5,6,7-tetrahydro­benzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]thiopyran­ 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteria­induced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.