公开(公告)号：EP1678147A1

公开(公告)日：2006-07-12

申请号：EP04786953.2

申请日：2004-09-15

申请人： GPC Biotech AG

发明人： CHOIDAS, Axel ,  BACKES, Alexander ,  COTTEN, Matt ,  ENGKVIST, Ola ,  FELBER, Beatrice ,  FREISLEBEN, Achim ,  GODL, Klaus ,  GREFF, Zoltán ,  HABENBERGER, Peter ,  HAFENBRADL, Doris ,  HARTUNG, Christian ,  HERGET, Thomas ,  HOPPE, Edmund ,  KLEBL, Bert ,  MISSIO, Andrea ,  MÜLLER, Gerhard ,  SCHWAB, Wilfried ,  ZECH, Birgit ,  BRAVO, Jose ,  HARRIS, John ,  LE, Joelle ,  MACRITCHIE, Jackie ,  SAVIC, Vladimir ,  SHERBORNE, Brad ,  SIMPSON, Don

IPC分类号： C07D239/42 ,  C07D401/12 ,  C07D239/48 ,  C07D403/12 ,  C07D401/04 ,  C07D409/12 ,  C07D417/12 ,  C07D405/12 ,  C07D409/14 ,  C07D413/12 ,  C07D409/04 ,  A61K31/505

CPC分类号： C04B35/632 ,  C07D239/42 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furhtermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.

公开(公告)号：EP1670804A2

公开(公告)日：2006-06-21

申请号：EP04786934.2

申请日：2004-09-10

申请人： GPC Biotech AG

发明人： KOUL, Anil ,  KLEBL, Bert ,  MÜLLER, Gerhard ,  MISSIO, Andrea ,  SCHWAB, Wilfried ,  HAFENBRADL, Doris ,  NEUMANN, Lars ,  SOMMER, Marc-Nicola ,  MÜLLER, Stefan ,  HOPPE, Edmund ,  FREISLEBEN, Achim ,  BACKES, Alexander ,  HARTUNG, Christian ,  FELBER, Beatrice ,  ZECH, Birgit ,  ENGKVIST, Ola ,  KERI, György ,  ÖRFI, Laszlo ,  BANHEGYI, Peter ,  GREFF, Zoltan ,  HORVATH, Zoltan ,  VARGA, Zoltan ,  MARKO, Péter ,  PATO, Jànos ,  SZABADKAI, Istvan ,  SZEKELYHIDI, Zsolt ,  WACZEK, Frigyes

IPC分类号： C07D495/04 ,  C07D495/10 ,  C07D493/04 ,  C07D491/04 ,  C07D409/12 ,  C07D333/66 ,  C07D333/68 ,  C07D209/42 ,  A61K31/381 ,  A61P31/04

CPC分类号： C07D409/12 ,  C07D209/42 ,  C07D333/66 ,  C07D333/68 ,  C07D491/04 ,  C07D493/04 ,  C07D495/04 ,  C07D495/10

摘要： Described are heterobicyclic compounds such as 4,5,6,7-tetrahydro­benzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]thiopyran­ 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteria­induced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.