公开(公告)号：EP2398481A2

公开(公告)日：2011-12-28

申请号：EP10711359.9

申请日：2010-02-18

申请人： Galapagos N.V.

发明人： JANSSEN, Richard, Antonius, Jozef ,  DE GROOT, Anton ,  LEKKERKERKER, Annemarie, Nicolette ,  MELDRUM, Eric, Charles ,  THOMPSON, Nicola ,  FATTAH, Dilniya

IPC分类号： A61K31/713 ,  G01N33/00 ,  C12N15/113 ,  A61P37/00

CPC分类号： A61K31/713 ,  C12N15/1136 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/12

摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the inhibition of the maturation of dendritic cells. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by maturation of dendritic cells including infections, allograft reactions, inflammation, allergic and autoimmune diseases, and cancer.

公开(公告)号：EP2240783A2

公开(公告)日：2010-10-20

申请号：EP09709228.2

申请日：2009-02-03

申请人： Galapagos N.V.

发明人： FISCHER, David, Frederik ,  JANSSEN, Richard, Antonius, Jozef ,  DE PRIL, Remko ,  VAN STEENHOVEN, Desire, Maria, Petronella, Catharina ,  KWAK, Seung ,  HOWLAND, David, S. ,  SIGNER, Ethan

IPC分类号： G01N33/68 ,  C07K14/47

CPC分类号： G01N33/6896 ,  C12N15/86 ,  C12N2710/10343 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2800/2835

摘要： The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing polyglutamine-induced protein aggregation, and/or altering huntingtin protein conformation, which inhibition is useful in the prevention, amelioration and / or treatment of neurodegenerative diseases, and protein aggregation diseases more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and / or treatment of Huntingtons disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these TARGETs.