专利检索 ap:("Galapagos N.V.") AND inv:"VAN STEENHOVEN, Desire, Maria, Petronella, Catharina" 第 1 页

1.

发明公开
MOLECULAR TARGETS AND COMPOUNDS, METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES. 审中-公开
标题翻译：靶分子以及用于治疗神经退行性疾病和方法IDENTIFZIERUNG化合物

公开(公告)号：EP2240783A2

公开(公告)日：2010-10-20

申请号：EP09709228.2

申请日：2009-02-03

申请人： Galapagos N.V.

发明人： FISCHER, David, Frederik , JANSSEN, Richard, Antonius, Jozef , DE PRIL, Remko , VAN STEENHOVEN, Desire, Maria, Petronella, Catharina , KWAK, Seung , HOWLAND, David, S. , SIGNER, Ethan

IPC分类号： G01N33/68 , C07K14/47

CPC分类号： G01N33/6896 , C12N15/86 , C12N2710/10343 , G01N2500/04 , G01N2500/10 , G01N2800/2835

摘要： The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing polyglutamine-induced protein aggregation, and/or altering huntingtin protein conformation, which inhibition is useful in the prevention, amelioration and / or treatment of neurodegenerative diseases, and protein aggregation diseases more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and / or treatment of Huntingtons disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these TARGETs.