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1.发明公开MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF JOINT DEGENERATIVE AND INFLAMMATORY DISEASES 有权分子靶点，查明炎症变性Erkankungen的处理组合物及方法
公开(公告)号：EP1817411A2
公开(公告)日：2007-08-15
申请号：EP05803408.3
申请日：2005-10-17
申请人： Galapagos N.V.
发明人： BRYS, Reginald , VANDEGHINSTE, Nick , TOMME, Peter, Herwig, Maria , KLAASSEN, Hubertus, Johanus, Matheus
CPC分类号： G01N33/6887 , A61K31/7088 , A61K38/00 , A61K48/00 , C12N7/00 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2710/10343 , C12Y304/24007 , G01N33/564 , G01N2333/9121 , G01N2800/102 , G01N2800/105
摘要： The application discloses methods for identifying and using compounds that inhibit extra-cellular matrix (ECM) degradation and inflammation, using a polypeptide sequence including SEQ ID NO: 17-127 (hereinafter 'TARGETS') and fragments thereof, expression inhibitory agents such as antisense polynucleotide, a ribozyme, and a small interfering RNA (siRNA), comprising a nucleic acid sequence complementary to, or engineered from, a naturally occurring polynucleotide sequence encoding a polypeptide of SEQ ID NO: 17-127, useful in pharmaceutical compositions comprising said agent, for the treatment, or prevention, of chronic joint degenerat ive and/or inflammatory diseases such as rheumatoid arthritis.
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2.发明授权MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF JOINT DEGENERATIVE AND INFLAMMATORY DISEASES 有权分子靶点，查明炎症变性Erkankungen的处理组合物及方法
公开(公告)号：EP1817411B1
公开(公告)日：2011-11-23
申请号：EP05803408.3
申请日：2005-10-17
申请人： Galapagos N.V.
发明人： BRYS, Reginald , VANDEGHINSTE, Nick , TOMME, Peter, Herwig, Maria , KLAASSEN, Hubertus, Johanus, Matheus
CPC分类号： G01N33/6887 , A61K31/7088 , A61K38/00 , A61K48/00 , C12N7/00 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2710/10343 , C12Y304/24007 , G01N33/564 , G01N2333/9121 , G01N2800/102 , G01N2800/105
摘要： The application discloses methods for identifying and using compounds that inhibit extra-cellular matrix (ECM) degradation and inflammation, using a polypeptide sequence including SEQ ID NO: 17-127 (hereinafter 'TARGETS') and fragments thereof, expression inhibitory agents such as antisense polynucleotide, a ribozyme, and a small interfering RNA (siRNA), comprising a nucleic acid sequence complementary to, or engineered from, a naturally occurring polynucleotide sequence encoding a polypeptide of SEQ ID NO: 17-127, useful in pharmaceutical compositions comprising said agent, for the treatment, or prevention, of chronic joint degenerat ive and/or inflammatory diseases such as rheumatoid arthritis.
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