-
1.发明授权
公开(公告)号：EP1773997B1
公开(公告)日：2011-11-23
申请号：EP05774134.0
申请日：2005-06-14
申请人： Galapagos N.V.
IPC分类号： C12N15/11
CPC分类号： C12Q1/37 , C12N9/6491 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/6887 , G01N2333/96486 , G01N2500/04 , G01N2800/102
摘要： The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inhibiting extra-cellular matrix degradation, including joint degenerative inhibiting and/or anti-inflammatory pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving extra-cellular matrix degradation in a subject.
-
2.发明授权MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF JOINT DEGENERATIVE AND INFLAMMATORY DISEASES 有权分子靶点，查明炎症变性Erkankungen的处理组合物及方法
公开(公告)号：EP1817411B1
公开(公告)日：2011-11-23
申请号：EP05803408.3
申请日：2005-10-17
申请人： Galapagos N.V.
发明人： BRYS, Reginald , VANDEGHINSTE, Nick , TOMME, Peter, Herwig, Maria , KLAASSEN, Hubertus, Johanus, Matheus
CPC分类号： G01N33/6887 , A61K31/7088 , A61K38/00 , A61K48/00 , C12N7/00 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2710/10343 , C12Y304/24007 , G01N33/564 , G01N2333/9121 , G01N2800/102 , G01N2800/105
摘要： The application discloses methods for identifying and using compounds that inhibit extra-cellular matrix (ECM) degradation and inflammation, using a polypeptide sequence including SEQ ID NO: 17-127 (hereinafter 'TARGETS') and fragments thereof, expression inhibitory agents such as antisense polynucleotide, a ribozyme, and a small interfering RNA (siRNA), comprising a nucleic acid sequence complementary to, or engineered from, a naturally occurring polynucleotide sequence encoding a polypeptide of SEQ ID NO: 17-127, useful in pharmaceutical compositions comprising said agent, for the treatment, or prevention, of chronic joint degenerat ive and/or inflammatory diseases such as rheumatoid arthritis.
-
3.发明公开MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF JOINT DEGENERATIVE AND INFLAMMATORY DISEASES 有权分子靶点，查明炎症变性Erkankungen的处理组合物及方法
公开(公告)号：EP1817411A2
公开(公告)日：2007-08-15
申请号：EP05803408.3
申请日：2005-10-17
申请人： Galapagos N.V.
发明人： BRYS, Reginald , VANDEGHINSTE, Nick , TOMME, Peter, Herwig, Maria , KLAASSEN, Hubertus, Johanus, Matheus
CPC分类号： G01N33/6887 , A61K31/7088 , A61K38/00 , A61K48/00 , C12N7/00 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2710/10343 , C12Y304/24007 , G01N33/564 , G01N2333/9121 , G01N2800/102 , G01N2800/105
摘要： The application discloses methods for identifying and using compounds that inhibit extra-cellular matrix (ECM) degradation and inflammation, using a polypeptide sequence including SEQ ID NO: 17-127 (hereinafter 'TARGETS') and fragments thereof, expression inhibitory agents such as antisense polynucleotide, a ribozyme, and a small interfering RNA (siRNA), comprising a nucleic acid sequence complementary to, or engineered from, a naturally occurring polynucleotide sequence encoding a polypeptide of SEQ ID NO: 17-127, useful in pharmaceutical compositions comprising said agent, for the treatment, or prevention, of chronic joint degenerat ive and/or inflammatory diseases such as rheumatoid arthritis.
-
4.发明公开
公开(公告)号：EP1773997A2
公开(公告)日：2007-04-18
申请号：EP05774134.0
申请日：2005-06-14
申请人： Galapagos N.V.
IPC分类号： C12N15/11
CPC分类号： C12Q1/37 , C12N9/6491 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/6887 , G01N2333/96486 , G01N2500/04 , G01N2800/102
摘要： The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inhibiting extra-cellular matrix degradation, including joint degenerative inhibiting and/or anti-inflammatory pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving extra-cellular matrix degradation in a subject.
-
-
-
搜索结果
4 条记录 (耗时 0.015 秒)
