公开(公告)号：EP2086540B1

公开(公告)日：2011-01-19

申请号：EP07857236.9

申请日：2007-11-30

申请人： Galapagos N.V. ,  BURRITT, Andrew

发明人： BURRITT, Andrew ,  EDWARDS, Paul John ,  SCHMIDT, Wolfgang ,  BIRAULT, Veronique ,  KROLL, Friedrich Erich Karl ,  TAO, Xueliang ,  ANDREWS, Martin James Inglis ,  MARTINA, Sébastien Laurent Xavier

IPC分类号： A61K31/437 ,  C07D471/04 ,  A61P29/00

CPC分类号： C07D471/04

摘要： Novel triazolopyridine compounds are disclosed that have a formula represented by Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non- limiting example, ECM degradation, joint degradation and/or inflammation, and others.

公开(公告)号：EP2086540A1

公开(公告)日：2009-08-12

申请号：EP07857236.9

申请日：2007-11-30

申请人： Galapagos N.V. ,  BURRITT, Andrew

发明人： BURRITT, Andrew ,  EDWARDS, Paul John ,  SCHMIDT, Wolfgang ,  BIRAULT, Veronique ,  KROLL, Friedrich Erich Karl ,  TAO, Xueliang ,  ANDREWS, Martin James Inglis ,  MARTINA, Sébastien Laurent Xavier

IPC分类号： A61K31/437 ,  C07D471/04 ,  A61P29/00

CPC分类号： C07D471/04

摘要： Novel triazolopyridine compounds are disclosed that have a formula represented by Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non- limiting example, ECM degradation, joint degradation and/or inflammation, and others.

公开(公告)号：EP2029602A2

公开(公告)日：2009-03-04

申请号：EP07729660.6

申请日：2007-05-30

申请人： Galapagos N.V.

发明人： ANDREWS, Martin James Inglis ,  EDWARDS, Paul ,  CHAMBERS, Mark Stuart ,  SCHMIDT, Wolfgang ,  CLASE, Juha Andrew ,  BAR, Gregory ,  HIRST, Kim Louise ,  MACLEOD, Angus

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61P29/00

CPC分类号： C07D487/04

摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following (formula I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

公开(公告)号：EP2029602B1

公开(公告)日：2010-04-21

申请号：EP07729660.6

申请日：2007-05-30

申请人： Galapagos N.V.

发明人： ANDREWS, Martin James Inglis ,  EDWARDS, Paul ,  CHAMBERS, Mark Stuart ,  SCHMIDT, Wolfgang ,  CLASE, Juha Andrew ,  BAR, Gregory ,  HIRST, Kim Louise ,  MACLEOD, Angus

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61P29/00

CPC分类号： C07D487/04

摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following (formula I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

公开(公告)号：EP2027124A1

公开(公告)日：2009-02-25

申请号：EP07729106.0

申请日：2007-05-14

申请人： Galapagos N.V.

发明人： BRYS, Reginald Christophe Xavier ,  EDWARDS, Paul ,  SCHMIDT, Wolfgang ,  ANDREWS, Martin James Inglis ,  CHAMBERS, Mark Stuart ,  CLASE, Juha Andrew ,  BIRAULT, Veronique ,  HIRST, Kim Louise ,  MACLEOD, Angus ,  BAR, Gregory ,  HARRIS, Clifford John ,  HUXLEY, Philip

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61P19/02

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula ( I ) represented by the following:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

公开(公告)号：EP2086540B8

公开(公告)日：2011-03-02

申请号：EP07857236.9

申请日：2007-11-30

申请人： Galapagos N.V.

发明人： BURRITT, Andrew ,  EDWARDS, Paul John ,  SCHMIDT, Wolfgang ,  BIRAULT, Veronique ,  KROLL, Friedrich Erich Karl ,  TAO, Xueliang ,  ANDREWS, Martin James Inglis ,  MARTINA, Sébastien Laurent Xavier

IPC分类号： A61K31/437 ,  C07D471/04 ,  A61P29/00

CPC分类号： C07D471/04

公开(公告)号：EP2099798A1

公开(公告)日：2009-09-16

申请号：EP07847622.3

申请日：2007-11-30

申请人： Galapagos N.V.

发明人： EDWARDS, Paul John ,  MARTINA, Sébastien Laurent Xavier ,  ANDREWS, Martin James Inglis ,  BAR, Grégory Louis Joseph ,  ALLART, Brigitte ,  BURRITT, Andrew ,  TAO, Xueliang ,  KROLL, Friedrich Erich Karl

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P29/00 ,  A61P19/02

CPC分类号： C07D471/04

摘要： Novel imidazolopyridine compounds are disclosed that have a formula represented by Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.

公开(公告)号：EP2307426A1

公开(公告)日：2011-04-13

申请号：EP09742103.6

申请日：2009-05-06

申请人： Galapagos N.V.

发明人： ANDREWS, Martin James Inglis ,  CHAMBERS, Mark Stuart ,  VAN DE POËL, Hervé ,  BAR, Grégory Louis Joseph

IPC分类号： C07D519/00 ,  A61K31/4985 ,  A61K31/4995 ,  A61P19/02

CPC分类号： C07D519/00

摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: Formula (Ia) or Formula (Ib). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non- limiting example, pain, inflammation, and others.