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    AN APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT
    1.
    发明公开
    AN APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT 有权
    一种用于体外血液处理的装置

    公开(公告)号：EP2688601A1

    公开(公告)日：2014-01-29

    申请号：EP12715144.7

    申请日：2012-03-20

    申请人： Gambro Lundia AB

    发明人： FONTANAZZI, Francesco ,  SURACE, Alessandro ,  PAOLINI, Francesco

    IPC分类号： A61M1/16

    CPC分类号： A61M1/3639 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/1613 ,  A61M1/341 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3393 ,  A61M2205/502 ,  A61M2205/52

    摘要： An apparatus (1) for extracorporeal blood treatment is described, comprising a treatment unit (2), an extracorporeal blood circuit (8), an infusion line (9, 9a, 9b) of a replacement fluid, a dialysis line connected in inlet to the second chamber (4), and a fluid evacuation line (10). The apparatus further comprises sensors for determining a first parameter relating to a patient's blood volume (BV%) a second parameter relating to an ultrafiltration flow rate (UFR) or to a patient's weight loss rate (WLR), a third parameter (Cd, Na) relating to a conductivity or concentration of a liquid crossing the dialysis line and/or the infusion line, and a fourth parameter relating to an infusion flow rate (QINF). Lastly, the apparatus comprises a control unit for performing a control procedure comprising receiving, from the sensors, the measured values of the above-cited parameters and calculating, on the basis of the measured values and the prescription values of the variation in blood volume (BV%target), the weight loss (WLtarget)> the plasma conductivity or sodium concentration(Ctarget, Natarget), the infusion volume (VINFtarget), control values to be imposed during a time interval following the control instant.

    摘要翻译： 本发明公开了一种用于体外血液处理的设备（1），其包括处理单元（2），体外血液回路（8），置换液输注管线（9,9a，9b），透析管线 第二腔室（4）和流体排出管线（10）。 该设备还包括用于确定与患者的血容量（BV％）有关的第一参数的传感器，涉及超滤流速（UFR）或患者的体重减轻速率（WLR）的第二参数，第三参数（Cd，Na ）涉及穿过透析管线和/或输注管线的液体的电导率或浓度，以及与输注流量（QINF）有关的第四参数。 最后，该设备包括用于执行控制过程的控制单元，该控制过程包括从传感器接收上述参数的测量值，并基于测量值和血容量变化的处方值（ BV靶标），体重减轻（WLtarget）>血浆电导率或钠浓度（Ctarget，Natarget），输注体积（VINF靶标），在控制时间之后的时间间隔期间施加的控制值。

    AN APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT
    2.
    发明公开
    AN APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT 有权
    GERÄTFÜREXTRAKORPORALE BLUTBEHANDLUNG

    公开(公告)号：EP2688600A1

    公开(公告)日：2014-01-29

    申请号：EP12712734.8

    申请日：2012-03-20

    申请人： Gambro Lundia AB

    发明人： FONTANAZZI, Francesco ,  SURACE, Alessandro ,  PAOLINI, Francesco

    IPC分类号： A61M1/16

    CPC分类号： A61M1/34 ,  A61M1/1605 ,  A61M1/1611 ,  A61M1/3403 ,  A61M1/3406 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3462 ,  A61M1/3465 ,  A61M2205/3334

    摘要： An apparatus (1 ) for extracorporeal blood treatment is described, comprising a treatment unit (2), an extracorporeal blood circuit (8), an infusion line (9, 9a, 9b) of a replacement fluid, a dialysis line connected in inlet to the second chamber (4), and a fluid evacuation line (10). The apparatus further comprises sensors for determining a first parameter relating to a patient's blood volume (BV%) a second parameter relating to an ultrafiltration flow rate (UFR) or to a patient's weight loss rate (WLR), a third parameter (Cd, Na) relating to a conductivity or concentration of a liquid crossing the dialysis line and/or the infusion line, and a fourth parameter relating to an infusion flow rate (QINF)- Lastly, the apparatus comprises a control unit for performing a control procedure (50) for regulating a variation in blood volume (BV%) and a setting sequence (200) for imposing a transmembrane pressure (TMP) to values which enable maximising the convective exchanges.

    摘要翻译： 一种用于体外血液处理的装置，包括处理单元; 体外血液回路; 更换液体的输液管线; 连接到第二室的入口的透析线; 排水管线; 用于确定与患者血容量（BV％）相关的第一参数的传感器，与超滤流量（UFR）或患者体重减轻率（WLR）相关的第二参数，与第三参数（Cd，Na）相关的第三参数 穿过透析线和/或输注线的液体的导电性或浓度以及与输注流量（QINF）相关的第四参数，以及执行控制程序以确定血容量变化（BV％ ）并且执行设置顺序，其中所述控制单元将跨膜压力（TMP）调节到能够使对流交换最大化的值。

    APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT I
    4.
    发明公开
    APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT I 审中-公开
    用于体外血液处理的装置I.

    公开(公告)号：EP3302605A1

    公开(公告)日：2018-04-11

    申请号：EP16724071.2

    申请日：2016-05-23

    申请人： Gambro Lundia AB

    发明人： ROVATTI, Paolo ,  SURACE, Alessandro ,  LODI, Carlo Alberto ,  WALLENBORG, Anders ,  NILSSON, Anders ,  SOLEM, Kristian ,  STERNBY, Jan ,  HERTZ, Thomas

    IPC分类号： A61M1/16 ,  A61M1/36

    摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood through the filtration unit (2), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.

    AN APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT
    6.
    发明公开
    AN APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT 审中-公开

    公开(公告)号：EP4046668A1

    公开(公告)日：2022-08-24

    申请号：EP21157807.5

    申请日：2021-02-18

    申请人： Gambro Lundia AB

    发明人： ROVATTI, Paolo ,  SURACE, Alessandro

    IPC分类号： A61M1/16 ,  A61M1/36

    摘要： A control unit of an apparatus for extracorporeal blood treatment is configured to perform a control procedure comprising: calculating parameter control values to be set during a time interval after the instant in which the control is made, on the basis of actual values and of prescription values of variation in blood volume, ultrafiltration flow rate, concentration of sodium and/or potassium and heart rate or variation of heart rate of the patient; imposing the parameter control values during the time interval consecutive to the instant in which the control is made such that the actual values of the variation in blood volume track the prescription values of the variation in blood volume over a predetermined treatment time and the actual values of the heart rate or variation of heart rate track the prescription values of the heart rate or variation of heart rate over the predetermined treatment time.

    AN APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT
    10.
    发明公开
    AN APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT 审中-公开

    公开(公告)号：EP4098291A1

    公开(公告)日：2022-12-07

    申请号：EP21176784.3

    申请日：2021-05-31

    申请人： Gambro Lundia AB

    发明人： ROVATTI, Paolo ,  SURACE, Alessandro

    IPC分类号： A61M1/16 ,  A61M1/36

    摘要： A control unit of an apparatus for extracorporeal blood treatment is configured to perform a control procedure comprising: calculating parameter control values to be set during a time interval after the instant in which the control is made, on the basis of actual values and of prescription values of variation in blood volume, ultrafiltration flow rate, concentration of sodium; imposing the parameter control values during the time interval consecutive to the instant in which the control is made such that the actual values of the variation in blood volume track the prescription values of the variation in blood volume over a predetermined treatment time. The control unit is further configured to perform a procedure for automatically estimating/calculating a target plasma conductivity and/or a target concentration of sodium in plasma to be reached at the end of the extracorporeal blood treatment.