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1.发明公开COMBINATION THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER 审中-公开随着对癌症紧密连接蛋白18.2的抗体治疗的联合治疗
公开(公告)号：EP2958945A1
公开(公告)日：2015-12-30
申请号：EP14707647.5
申请日：2014-02-18
申请人： Ganymed Pharmaceuticals AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN,Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , WÖLL, Stefan , JACOBS, Stefan , HEINZ, Cornelia
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/28 , C07K16/303 , C07K2317/73 , C07K2317/732 , C07K2317/734 , A61K2300/00
摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as pancreatic cancer and metastases thereof.
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公开(公告)号：EP4285911A2
公开(公告)日：2023-12-06
申请号：EP23200924.1
申请日：2010-02-19
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , HELFTENBEIN, Gerd , KORDEN, Walter , WÖLL, Stefan , OPREA, Gabriela-Elena
IPC分类号： A61K31/7088
摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.
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公开(公告)号：EP3679069A1
公开(公告)日：2020-07-15
申请号：EP18765858.8
申请日：2018-09-05
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C07K16/28
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公开(公告)号：EP3026064B1
公开(公告)日：2018-10-17
申请号：EP15201110.2
申请日：2012-04-20
申请人： Ganymed Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael , WEICHEL, Michael
IPC分类号： C07K16/30 , A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/30 , A61K39/39591 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor- related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
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公开(公告)号：EP4461354A2
公开(公告)日：2024-11-13
申请号：EP24193389.4
申请日：2010-11-11
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael
IPC分类号： A61P1/18
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
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公开(公告)号：EP4285911A3
公开(公告)日：2024-04-10
申请号：EP23200924.1
申请日：2010-02-19
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , HELFTENBEIN, Gerd , KORDEN, Walter , WÖLL, Stefan , OPREA, Gabriela-Elena
IPC分类号： C12N15/11 , A61K31/7088 , C07K14/47 , C07K16/18 , A61K39/00 , A61P35/00 , A61P35/04 , A61P37/04 , C12N15/113
摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.
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公开(公告)号：EP4036119A1
公开(公告)日：2022-08-03
申请号：EP22152178.4
申请日：2013-05-06
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , WÖLL, Stefan
摘要： The invention relates to antibodies directed against an epitope located within the C-terminal portion of CLDN18.2 which are useful, for example, in diagnosing cancer and/or in determining whether cancer cells express CLDN18.2.
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公开(公告)号：EP4177273A1
公开(公告)日：2023-05-10
申请号：EP22201152.0
申请日：2014-02-18
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , WÖLL, Stefan , JACOBS, Stefan , HEINZ, Cornelia
IPC分类号： C07K16/30 , A61K39/00 , A61K39/395 , C07K16/28
摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as pancreatic cancer and metastases thereof.
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公开(公告)号：EP2847225B1
公开(公告)日：2019-11-27
申请号：EP13721596.8
申请日：2013-05-06
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , WÖLL, Stefan
IPC分类号： C07K16/30
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10.发明公开ANTIBODIES FOR TREATMENT OF CANCER EXPRESSING CLAUDIN 6 审中-公开安东尼奥ZUR BEHANDLUNG VON CLAUDIN 6 EXPRIMIERENDEM KARZINOM
公开(公告)号：EP3026064A1
公开(公告)日：2016-06-01
申请号：EP15201110.2
申请日：2012-04-20
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael , WEICHEL, Michael
IPC分类号： C07K16/30 , A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/30 , A61K39/39591 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor- related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLDN6的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌，皮肤癌，恶性肿瘤 黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。
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