公开(公告)号：EP3312197A1

公开(公告)日：2018-04-25

申请号：EP17192466.5

申请日：2006-11-24

申请人： Ganymed Pharmaceuticals GmbH ,  Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten

发明人： Sahin, Ugur ,  Türeci, Özlem ,  Usener, Dirk ,  Fritz, Stefan ,  Uherek, Christoph ,  Brandenburg, Gunda ,  Geppert, Harald-Gerhard ,  Schröder, Anja Kristina ,  Thiel, Philippe

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  C12N5/12 ,  A61K51/10 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  A61K39/00

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6807 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6821 ,  A61K47/6823 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K51/1063 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

摘要翻译： 本发明提供了可用作治疗剂的抗体，所述抗体用于治疗和/或预防与表达CLD18的细胞相关的疾病，所述疾病包括肿瘤相关疾病，例如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌，头 - 癌症和胆囊癌。

公开(公告)号：EP2325210A1

公开(公告)日：2011-05-25

申请号：EP10011772.0

申请日：2006-11-24

申请人： Ganymed Pharmaceuticals AG ,  Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten

发明人： Sahin, Ugur ,  Türeci, Özlem ,  Usener, Dirk ,  Fritz, Stefan ,  Uherek, Christoph ,  Brandenburg, Gunda ,  Geppert, Harald-Gerhard ,  Schröder, Anja Kristina ,  Thiel, Philippe

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  C12N5/12 ,  A61K47/48

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6807 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6821 ,  A61K47/6823 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K51/1063 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

摘要翻译： 本发明提供了可用作治疗剂的抗体，所述抗体用于治疗和/或预防与表达CLD18的细胞相关的疾病，所述疾病包括肿瘤相关疾病，例如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌，头 - 癌症和胆囊癌。

公开(公告)号：EP2311878A3

公开(公告)日：2011-05-18

申请号：EP10011775.3

申请日：2006-11-24

申请人： Ganymed Pharmaceuticals AG ,  Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten

发明人： Sahin, Ugur ,  Türeci, Özlem ,  Usener, Dirk ,  Fritz, Stefan ,  Uherek, Christoph ,  Brandenburg, Gunda ,  Geppert, Harald-Gerhard ,  Schröder, Anja Kristina ,  Thiel, Philippe

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  C12N5/12 ,  A61K47/48

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6807 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6821 ,  A61K47/6823 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K51/1063 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

公开(公告)号：EP2311879A2

公开(公告)日：2011-04-20

申请号：EP10011776.1

申请日：2006-11-24

申请人： Ganymed Pharmaceuticals AG ,  Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten

发明人： Sahin, Ugur ,  Türeci, Özlem ,  Usener, Dirk ,  Fritz, Stefan ,  Uherek, Christoph ,  Brandenburg, Gunda ,  Geppert, Harald-Gerhard ,  Schröder, Anja Kristina ,  Thiel, Philippe

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  C12N5/12 ,  A61K47/48

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6807 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6821 ,  A61K47/6823 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K51/1063 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

公开(公告)号：EP2311878A2

公开(公告)日：2011-04-20

申请号：EP10011775.3

申请日：2006-11-24

申请人： Ganymed Pharmaceuticals AG ,  Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten

发明人： Sahin, Ugur ,  Türeci, Özlem ,  Usener, Dirk ,  Fritz, Stefan ,  Uherek, Christoph ,  Brandenburg, Gunda ,  Geppert, Harald-Gerhard ,  Schröder, Anja Kristina ,  Thiel, Philippe

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  C12N5/12 ,  A61K47/48

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6807 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6821 ,  A61K47/6823 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K51/1063 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

摘要翻译： 本发明提供了可用作治疗剂的抗体，所述抗体用于治疗和/或预防与表达CLD18的细胞相关的疾病，所述疾病包括肿瘤相关疾病，例如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌，头 - 癌症和胆囊癌。

公开(公告)号：EP2295469A3

公开(公告)日：2011-05-18

申请号：EP10011774.6

申请日：2006-11-24

申请人： Ganymed Pharmaceuticals AG ,  Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten

发明人： Sahin, Ugur ,  Türeci, Özlem ,  Usener, Dirk ,  Fritz, Stefan ,  Uherek, Christoph ,  Brandenburg, Gunda ,  Geppert, Harald-Gerhard ,  Schröder, Anja Kristina ,  Thiel, Philippe

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  C12N5/12 ,  A61K47/48

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6807 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6821 ,  A61K47/6823 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K51/1063 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

公开(公告)号：EP2311877B1

公开(公告)日：2015-08-26

申请号：EP10011773.8

申请日：2006-11-24

申请人： Ganymed Pharmaceuticals AG ,  Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten

发明人： Sahin, Ugur ,  Türeci, Özlem ,  Usener, Dirk ,  Fritz, Stefan ,  Uherek, Christoph ,  Brandenburg, Gunda ,  Geppert, Harald-Gerhard ,  Schröder, Anja Kristina ,  Thiel, Philippe

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  C12N5/12 ,  A61K47/48 ,  A61K51/10

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6807 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6821 ,  A61K47/6823 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K51/1063 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

公开(公告)号：EP2311877A3

公开(公告)日：2011-05-18

申请号：EP10011773.8

申请日：2006-11-24

申请人： Ganymed Pharmaceuticals AG ,  Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten

发明人： Sahin, Ugur ,  Türeci, Özlem ,  Usener, Dirk ,  Fritz, Stefan ,  Uherek, Christoph ,  Brandenburg, Gunda ,  Geppert, Harald-Gerhard ,  Schröder, Anja Kristina ,  Thiel, Philippe

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  C12N5/12 ,  A61K47/48

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6807 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6821 ,  A61K47/6823 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K51/1063 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

公开(公告)号：EP2311878B1

公开(公告)日：2015-10-07

申请号：EP10011775.3

申请日：2006-11-24

申请人： Ganymed Pharmaceuticals AG ,  Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten

发明人： Sahin, Ugur ,  Türeci, Özlem ,  Usener, Dirk ,  Fritz, Stefan ,  Uherek, Christoph ,  Brandenburg, Gunda ,  Geppert, Harald-Gerhard ,  Schröder, Anja Kristina ,  Thiel, Philippe

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  C12N5/12 ,  A61K47/48 ,  A61K51/10

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6807 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6821 ,  A61K47/6823 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K51/1063 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

公开(公告)号：EP2311879A3

公开(公告)日：2011-05-18

申请号：EP10011776.1

申请日：2006-11-24

申请人： Ganymed Pharmaceuticals AG ,  Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten

发明人： Sahin, Ugur ,  Türeci, Özlem ,  Usener, Dirk ,  Fritz, Stefan ,  Uherek, Christoph ,  Brandenburg, Gunda ,  Geppert, Harald-Gerhard ,  Schröder, Anja Kristina ,  Thiel, Philippe

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  C12N5/12 ,  A61K47/48

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6807 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6821 ,  A61K47/6823 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K51/1063 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌，头部 - 癌症和胆囊癌。