公开(公告)号：EP1743036A2

公开(公告)日：2007-01-17

申请号：EP05705750.7

申请日：2005-01-14

申请人： Genaissance Pharmaceuticals, Inc.

发明人： AERSSENS, Jeroen ,  ATHANASIOU, Maria ,  BRAIN, Carlos ,  COHEN, Nadine ,  DAIN, Bradley ,  DENTON, R. Rex ,  JUDSON, Richard S. ,  OZDEMIR, Vural ,  REED, Carol R.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172

摘要： Haplotypes in the APOE gene associated with age of onset of Alzheimer’s Disease are disclosed. Compositions and methods for detecting and using these APOE haplotypes in a variety of clinical applications are disclosed. Such applications include articles of manufacture comprising compounds effective in delaying the age of onset of AD in individuals at risk for developing AD and having one of these APOE haplotypes, methods and kits for predicting the age of onset of AD in an individual at risk for developing AD based upon his/her haplotype profile, and methods for delaying the age of onset of AD in individuals at risk for developing AD based upon their haplotype profile.

公开(公告)号：EP1280814A1

公开(公告)日：2003-02-05

申请号：EP00923375.0

申请日：2000-04-13

申请人： Genaissance Pharmaceuticals, Inc. ,  UNIVERSITY OF CINCINNATI

发明人： STACK, Catherine, B. ,  DRYSDALE, Connie, M. ,  STEPHENS, J., Claiborne ,  NANDABALAN, Krishnan ,  JUDSON, Richard S. ,  LIGGETT, Stephen B.

IPC分类号： C07H21/04 ,  C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6883 ,  C07K14/70571 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

摘要： Genotypes and haplotypes for thirteen polymorphic sites in the β2-adrenergic receptor (β2AR) gene are disclosed. Compositions and methods for predicting genetic predisposition to disease associated with polymorphic sites in the (β2AR) gene, as well as for predicting response to β-agonists, are also disclosed.

摘要翻译： 公开了β2-肾上腺素能受体（β2AR）基因中13个多态性位点的基因型和单倍型。 还公开了用于预测与（β2AR）基因中的多态性位点相关的疾病的遗传易感性以及预测对β-激动剂的反应的组合物和方法。