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公开(公告)号：EP1549663A2
公开(公告)日：2005-07-06
申请号：EP03724548.7
申请日：2003-05-12
发明人： CHEN, Yiyou , DAY, Anthony, G. , EDWARDS, Cynthia , MURRAY, Christopher, J. , SCHELLENBERGER, Volker
IPC分类号： C07K1/00
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/6415 , A61K47/67 , A61K47/6891 , A61K48/00 , C07K2319/00 , C07K2319/50 , C07K2319/55 , C07K2319/70 , C12N9/50 , C12N9/86 , C12N15/1044 , C12N15/62
摘要： The present invention provides methods and compositions relating to polypeptides engineered to bind a target and have at least two functional domains.
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公开(公告)号：EP1360500A2
公开(公告)日：2003-11-12
申请号：EP01930480.7
申请日：2001-04-11
IPC分类号： G01N33/68
CPC分类号： G01N33/54393 , C07K7/06 , C07K7/08 , C12N15/1034 , C12N15/1037 , C12N15/1072 , C40B40/02 , G01N33/6845 , G01N2500/02
摘要： A selective targeting method is disclosed comprising contacting a library of ligands, particularly a peptide library, with an anti-target to allow the ligands to bind to the anti-target; separating the non-binding ligands from the anti-target bound ligands, contacting the non-binding anti-target ligands with a target allowing the unbound ligands to bind with the target to form a target-bound ligand complex; separating the target-bound ligand complex from ligands which do not bind to the target, and identifying the target-bound ligands on the target-bound ligand complex wherein the target-bound ligands have a KD in the range of about 10?-7 to 10-10¿ M. Additionally claimed are the ligands identified according to the method.
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公开(公告)号：EP1799717A2
公开(公告)日：2007-06-27
申请号：EP05858248.7
申请日：2005-10-18
发明人： CHEN, Yiyou , CHEN, Dan , DAY, Anthony, G. , ESTELL, David, A. , GENG, Wei
CPC分类号： C07K16/00 , C07K2317/92
摘要： The invention is drawn to a method of isolating human antibodies.
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公开(公告)号：EP1571909A2
公开(公告)日：2005-09-14
申请号：EP03777539.2
申请日：2003-10-03
发明人： SETTE, Alessandro , CHESNUT, Robert , NEWMAN, Mark J. , LIVINGSTON, Brian D. , BABE, Lilia Maria , CHEN, Yiyou , DEYOUNG, Lawrence M. , HUANG, Manley T.F. , POWER, Scott D.
CPC分类号： A61K39/292 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/6031 , A61K2039/605 , A61K2039/645 , C07K14/005 , C12N2730/10122 , C12N2730/10134
摘要： The invention relates to the field of biology. In particular, it relates to multi-epitope nucleic acid and peptide vaccines and methods of designing such vaccines to provide increased immunogenicity.
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公开(公告)号：EP1750759A2
公开(公告)日：2007-02-14
申请号：EP05749128.4
申请日：2005-05-12
发明人： CHEN, Yiyou
CPC分类号： G01N33/6857 , C07K16/005 , C07K2317/22
摘要： The present invention relates to a method of screening which includes an antibody heavy chain and a reporter gene, such as a camel antibody and beta-lactamase, respectively.
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公开(公告)号：EP1341907A2
公开(公告)日：2003-09-10
申请号：EP01991146.0
申请日：2001-12-14
发明人： CHEN, Yiyou , DAY, Anthony, G. , ESTELL, David, A. , MURRAY, Christopher, J. , POWER, Scott, D. , SCHELLENBERGER, Volker
IPC分类号： C12N9/86
摘要： The present invention provides targeted enzymes that bind to targets better than the corresponding pre-targeted enzymes bind the target under like conditions, methods of making targeted enzymes, methods of using targeted enzymes to treat diseases, and pharmaceutical compositions comprising targeted enzymes.
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公开(公告)号：EP1360500B1
公开(公告)日：2010-01-13
申请号：EP01930480.7
申请日：2001-04-11
IPC分类号： G01N33/68
CPC分类号： G01N33/54393 , C07K7/06 , C07K7/08 , C12N15/1034 , C12N15/1037 , C12N15/1072 , C40B40/02 , G01N33/6845 , G01N2500/02
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