公开(公告)号：EP1549663A2

公开(公告)日：2005-07-06

申请号：EP03724548.7

申请日：2003-05-12

申请人： Genencor International, Inc.

发明人： CHEN, Yiyou ,  DAY, Anthony, G. ,  EDWARDS, Cynthia ,  MURRAY, Christopher, J. ,  SCHELLENBERGER, Volker

IPC分类号： C07K1/00

CPC分类号： B82Y5/00 ,  A61K38/00 ,  A61K47/6415 ,  A61K47/67 ,  A61K47/6891 ,  A61K48/00 ,  C07K2319/00 ,  C07K2319/50 ,  C07K2319/55 ,  C07K2319/70 ,  C12N9/50 ,  C12N9/86 ,  C12N15/1044 ,  C12N15/62

摘要： The present invention provides methods and compositions relating to polypeptides engineered to bind a target and have at least two functional domains.

公开(公告)号：EP1002098B1

公开(公告)日：2004-08-25

申请号：EP98935504.5

申请日：1998-06-29

申请人： GENENCOR INTERNATIONAL, INC.

发明人： DAY, Anthony, G.

IPC分类号： C12N15/55 ,  C12N9/28 ,  C12P19/14 ,  C12S3/12 ,  C11D3/386 ,  C12N1/21

CPC分类号： C12N9/2417 ,  C11D3/386

摘要： Novel α-amylase enzymes are disclosed in which one or more disulfide bonds are introduced into the enzyme via addition or substitution of a residue with a cysteine. The disclosed α-amylase enzymes show altered or improved stability and/or activity profiles.

公开(公告)号：EP1800136A2

公开(公告)日：2007-06-27

申请号：EP05810831.7

申请日：2005-10-14

申请人： GENENCOR INTERNATIONAL, INC.

发明人： DAY, Anthony, G. ,  ESTELL, David, A. ,  JEDZEJEWSKI, Paul, T. ,  MURRAY, Christopher, J.

IPC分类号： G01N33/68

CPC分类号： C40B30/04 ,  G01N2333/811

摘要： The invention is drawn to a novel method useful for screening. In particular, the present invention provides methods for competitive differential screening. In some preferred embodiments, the present invention provides methods for competitive differential screening that facilitate the identification of tight binders. In some preferred embodiments, the agents used in the methods of the present invention comprise tight and weak binders. In other embodiments, the present invention provides methods that utilize competitive binders that recognize and bind targets, but with binding that is less strong than that of binders of interest.

公开(公告)号：EP1242668B1

公开(公告)日：2006-04-05

申请号：EP00988111.1

申请日：2000-12-16

申请人： GENENCOR INTERNATIONAL, INC.

发明人： DAY, Anthony, G. ,  POWER, Scott, D. ,  WINETZKY, Deborah, S. ,  VICTORIA, Doreen

IPC分类号： D06L3/11 ,  D06M16/00

CPC分类号： D06L4/40

摘要： A method is provided for bleaching a non-cotton cellulosic fiber, yarn or fabric by contacting said fiber, yarn or fabric with a hemicellulase enzyme for a time and under conditions suitable to produce a whitening of said fiber, yarn or fabric.

摘要翻译： 提供了一种通过使纤维，纱线或织物与半纤维素酶接触一段时间并在适于产生所述纤维，纱线或织物的增白的条件下漂白非棉纤维素纤维，纱线或织物的方法。

公开(公告)号：EP1578943A2

公开(公告)日：2005-09-28

申请号：EP03788539.9

申请日：2003-08-15

申请人： GENENCOR INTERNATIONAL, INC.

发明人： DAY, Anthony, G. ,  GOEDEGEBUUR, Frits ,  GUALFETTI, Peter ,  MITCHINSON, Colin ,  NEEFE, Paulien ,  SANDGREN, Mats ,  SHAW, Andrew ,  STAHLBERG, Jerry

IPC分类号： C12N1/00

CPC分类号： C12N9/2437 ,  C11D3/38645 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01091 ,  D21C5/005 ,  Y02E50/16

摘要： Described herein are variants of H. jecorina CBHI, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.

公开(公告)号：EP1240524A2

公开(公告)日：2002-09-18

申请号：EP00984363.2

申请日：2000-12-14

申请人： GENENCOR INTERNATIONAL, INC.

发明人： DAY, Anthony, G. ,  MITCHINSON, Colin ,  SHAW, Andrew

IPC分类号： G01N33/68 ,  C12Q1/00 ,  C12Q1/40 ,  C12Q1/37 ,  C12Q1/34

CPC分类号： C12N9/2417 ,  C12N9/00 ,  C12N9/2437 ,  C12Y302/01004

摘要： An improved protein comprising an amino acid sequence which has been modified from a precursor amino acid sequence by the substitution or deletion of an amino acid residue which differs from a corresponding amino acid residue in a less stable but homologous protein, wherein said improved protein has improved properties compared to a protein corresponding to the precursor amino acid sequence.

公开(公告)号：EP1002098A1

公开(公告)日：2000-05-24

申请号：EP98935504.5

申请日：1998-06-29

申请人： GENENCOR INTERNATIONAL, INC.

发明人： DAY, Anthony, G.

IPC分类号： C12N15/55 ,  C12N9/28 ,  C12P19/14 ,  C12S3/12 ,  C11D3/386 ,  C12N1/21

CPC分类号： C12N9/2417 ,  C11D3/386

摘要： Novel α-amylase enzymes are disclosed in which one or more disulfide bonds are introduced into the enzyme via addition or substitution of a residue with a cysteine. The disclosed α-amylase enzymes show altered or improved stability and/or activity profiles.

公开(公告)号：EP1799717A2

公开(公告)日：2007-06-27

申请号：EP05858248.7

申请日：2005-10-18

申请人： GENENCOR INTERNATIONAL, INC.

发明人： CHEN, Yiyou ,  CHEN, Dan ,  DAY, Anthony, G. ,  ESTELL, David, A. ,  GENG, Wei

IPC分类号： C07K16/18 ,  C12N5/08

CPC分类号： C07K16/00 ,  C07K2317/92

摘要： The invention is drawn to a method of isolating human antibodies.

公开(公告)号：EP1692159A2

公开(公告)日：2006-08-23

申请号：EP04810432.7

申请日：2004-11-06

申请人： GENENCOR INTERNATIONAL, INC.

发明人： DAY, Anthony, G. ,  ESTELL, David A. ,  MURRAY, Christopher, J. ,  POWER, Scott, D. ,  TURNQUEST, Beverly, R.

IPC分类号： C07K7/06 ,  C07K14/81 ,  C07K19/00 ,  A61K38/08 ,  A61K38/16 ,  C12N15/11

CPC分类号： C07K14/81 ,  A61K38/00 ,  C07K7/06 ,  C07K14/811 ,  C07K2319/00 ,  C12N15/62

摘要： The present invention provides peptides and supported peptides that bind TGFβ( molecules. In some particularly preferred embodiments, the TGFβ binding molecules bind TGFβ-1, while in other embodiments, the TGFβ binding molecules bind TGFβ-2.

公开(公告)号：EP1328645A2

公开(公告)日：2003-07-23

申请号：EP01957356.7

申请日：2001-07-31

申请人： GENENCOR INTERNATIONAL, INC.

发明人： DAY, Anthony, G. ,  GUALFETTI, Peter ,  MITCHINSON, Colin ,  SHAW, Andrew

IPC分类号： C12N15/56 ,  C12N9/42 ,  C11D3/386 ,  D21C5/00 ,  D06M16/00

CPC分类号： C12N9/2437 ,  A23K20/189 ,  C11D3/38645 ,  C12Y302/01004 ,  D06M16/003 ,  D06P1/228 ,  D06P5/137 ,  D06P5/158

摘要： The present invention relates to novel variant EGIII or EGIII-like cellulases which have improved stability. The variant cellulases have performance sensitive residues replaced to a residue having modified stability.