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公开(公告)号：EP2111413A2
公开(公告)日：2009-10-28
申请号：EP08729968.1
申请日：2008-02-15
申请人： Genentech, Inc.
发明人： APPLETON, Brent, A. , RUNYON, Steven, T. , SIDHU, Sachdev, S. , SKELTON, Nicholas, J. , WIESMANN, Christian , ZHANG, Yingnan
IPC分类号： C07K14/435
CPC分类号： C07K7/08 , C07K5/1008 , C07K7/06 , C12N9/6424
摘要： The invention provides optimized HtrA1 PDZ domain and HtrA3 PDZ domain ligands. The invention further provides modulators of HtrA1 PDZ domain-ligand interaction and HtrA3 PDZ domain-ligand interaction, and methods of identifying and using these modulators.
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2.发明授权CRYSTAL STRUCTURES OF NEUROPILIN FRAGMENTS AND NEUROPILIN-ANTIBODY COMPLEXES 有权NEUROPILINFRAGMENTEN的晶体结构和神经毡抗体复合物
公开(公告)号：EP2158215B1
公开(公告)日：2015-04-22
申请号：EP07762242.1
申请日：2007-05-17
申请人： Genentech, Inc.
IPC分类号： C07K14/71
CPC分类号： C07K14/71 , C07K16/2863 , C07K2299/00 , C07K2317/55 , C07K2317/76
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3.发明公开CRYSTAL STRUCTURES OF NEUROPILIN FRAGMENTS AND NEUROPILIN-ANTIBODY COMPLEXES 有权NEUROPILINFRAGMENTEN的晶体结构和神经毡抗体复合物
公开(公告)号：EP2158215A2
公开(公告)日：2010-03-03
申请号：EP07762242.1
申请日：2007-05-17
申请人： Genentech, Inc.
IPC分类号： C07K14/71
CPC分类号： C07K14/71 , C07K16/2863 , C07K2299/00 , C07K2317/55 , C07K2317/76
摘要： The invention provides crystal structures of neuropilin 1 (Nrp1) and neuropilin 2 (Nrp2) fragments alone and in complex with anti-neuropilin antibodies, and method for their use. The invention further provides anti-Nrp antibodies and methods for their therapeutic applications.
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