-
公开(公告)号：EP2016101A2
公开(公告)日：2009-01-21
申请号：EP07797370.9
申请日：2007-05-08
申请人： Genentech, Inc.
IPC分类号： C07K16/32
CPC分类号： C07K16/00 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569
摘要： The invention provides variant heavy chain variable domains (VH) with increased folding stability. Libraries comprising a plurality of these polypeptides are also provided. In addition, compositions and methods of generating and using these polypeptides and libraries are provided.
-
公开(公告)号：EP1513879B1
公开(公告)日：2018-08-22
申请号：EP03734379.5
申请日：2003-06-03
申请人： Genentech, Inc.
IPC分类号： C07K16/00 , C07H21/04 , C12N15/00 , C12N7/00 , A61K39/395
CPC分类号： C07K16/22 , C07K16/32 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The invention provides comprising variant amino acids in CDRs of antibody variable domains. These polypeptides provide a source of great sequence diversity that can be used as a source for identifying novel antigen binding polypeptides. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags, and linkers. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.
-
公开(公告)号：EP1756164A2
公开(公告)日：2007-02-28
申请号：EP05769494.5
申请日：2005-04-04
申请人： GENENTECH, INC.
发明人： LI, Bing , SIDHU, Sachdev, S.
IPC分类号： C07K16/28 , A61P37/00 , A61K39/395 , C07K16/32 , A61P35/00
CPC分类号： C07K16/2878 , C07K2317/24 , C07K2317/55 , C07K2317/622
摘要： The application provides antibodies which specifically bind to DR5 receptor. The anti-DR5 antibodies optionally contain CDR sequences identified using phage-display techniques. The DR5 antibodies can be used, for example, in methods where a modulation of the biological activities of Apo-2L and/or Apo-2L receptors is desired, including cancer and immune-related conditions.
-
公开(公告)号：EP1622929B1
公开(公告)日：2006-10-11
申请号：EP04760861.7
申请日：2004-04-29
申请人： GENENTECH, INC.
发明人： LI, Bing , SIDHU, Sachdev, S.
IPC分类号： C07K7/04 , A61K38/04 , C07K14/705 , C12N15/10
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/47 , C07K14/4747 , C07K14/525 , C07K14/70575
摘要： Peptides are provided that bind Apo-2L receptor molecules. These peptides can be used for example in methods where a modulation of the biological activities of Apo-2L and/or Apo-2L receptor molecules such as DR5 is desired.
摘要翻译： 提供结合Apo-2L受体分子的肽。 这些肽可用于例如需要调节Apo-2L和/或Apo-2L受体分子如DR5的生物活性的方法中。
-
公开(公告)号：EP2002259B1
公开(公告)日：2012-05-16
申请号：EP07760350.4
申请日：2007-04-09
申请人： Genentech, Inc.
发明人： COSTA, Mike , SIDHU, Sachdev, S. , ZHANG, Yingnan
CPC分类号： G01N33/57496 , C07K7/06 , C07K2319/01 , G01N2500/02
摘要： The invention provides modulators of Dvl PDZ-ligand interaction, and methods of identifying and using these modulators.
-
公开(公告)号：EP2111413A2
公开(公告)日：2009-10-28
申请号：EP08729968.1
申请日：2008-02-15
申请人： Genentech, Inc.
发明人： APPLETON, Brent, A. , RUNYON, Steven, T. , SIDHU, Sachdev, S. , SKELTON, Nicholas, J. , WIESMANN, Christian , ZHANG, Yingnan
IPC分类号： C07K14/435
CPC分类号： C07K7/08 , C07K5/1008 , C07K7/06 , C12N9/6424
摘要： The invention provides optimized HtrA1 PDZ domain and HtrA3 PDZ domain ligands. The invention further provides modulators of HtrA1 PDZ domain-ligand interaction and HtrA3 PDZ domain-ligand interaction, and methods of identifying and using these modulators.
-
7.发明公开APO2L (TRAIL) RECEPTOR BINDING PEPTIDES AND USES THEREOF 有权肽什么对Apo2L（TRAIL）受体的结合和VERWENDUNGNEN THEREOF
公开(公告)号：EP1622929A2
公开(公告)日：2006-02-08
申请号：EP04760861.7
申请日：2004-04-29
申请人： GENENTECH, INC.
发明人： LI, Bing , SIDHU, Sachdev, S.
IPC分类号： C07K7/04 , A61K38/04 , C07K14/705 , C12N15/10
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/47 , C07K14/4747 , C07K14/525 , C07K14/70575
摘要： Peptides are provided that bind Apo-2L receptor molecules. These peptides can be used for example in methods where a modulation of the biological activities of Apo-2L and/or Apo-2L receptor molecules such as DR5 is desired.
-
8.发明公开IMPROVED TRANSFORMATION EFFICIENCY IN PHAGE DISPLAY THROUGH MODIFICATION OF A COAT PROTEIN 审中-公开提高PHAG显示转化效率通过修改包膜蛋白
公开(公告)号：EP1100890A2
公开(公告)日：2001-05-23
申请号：EP99935837.7
申请日：1999-07-22
申请人： Genentech, Inc.
CPC分类号： C40B40/02 , C07K14/005 , C07K2319/00 , C12N15/1037 , C12N2795/10022 , C12N2795/10043
摘要： The transformation yield of electroporation is increased by using higher DNA concentrations and DNA affinity purification. Fusion proteins of a viral coat protein variant and a heterologous polypeptide are useful in phage display systems.
-
公开(公告)号：EP2280996A2
公开(公告)日：2011-02-09
申请号：EP09743591.1
申请日：2009-05-06
申请人： Genentech, Inc.
IPC分类号： C07K14/705 , G01N33/68 , A61K38/17 , A61P37/00
CPC分类号： A61K38/1774 , A61K38/00 , C07K14/70503 , Y02A50/463
摘要： The present invention concerns affinity matured CRIg variants. In particular, the invention concerns CRIg variants having increased binding affinity to C3b and retaining selective binding to C3b over C3.
-
公开(公告)号：EP2002259A2
公开(公告)日：2008-12-17
申请号：EP07760350.4
申请日：2007-04-09
申请人： Genentech, Inc.
发明人： COSTA, Mike , SIDHU, Sachdev, S. , ZHANG, Yingnan
CPC分类号： G01N33/57496 , C07K7/06 , C07K2319/01 , G01N2500/02
摘要： The invention provides modulators of Dvl PDZ-ligand interaction, and methods of identifying and using these modulators.
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.023 秒)
