-
公开(公告)号：EP1292680A2
公开(公告)日：2003-03-19
申请号：EP01950429.9
申请日：2001-06-22
申请人： Genentech, Inc.
IPC分类号： C12N15/13 , C07K16/28 , C12N5/10 , C12N15/63 , A61K39/395 , A61P25/00 , A61P25/28 , A61P9/00
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34
摘要： The invention concerns agonist anti-trkC monoclonal antoibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, including nerve cell damage associated with acute nervous cell system injury and chronic neurodegenerative diseases, including peripheral neuropathy.
-
公开(公告)号：EP1107996A1
公开(公告)日：2001-06-20
申请号：EP99943928.4
申请日：1999-08-26
申请人： Genentech, Inc.
发明人： ADAMS, Camellia, W. , DEVAUX, Brigitte , EATON, Dan, L. , HASS, Philip, E. , JUDICE, J., Kevin , KIRCHHOFER, Daniel , SUGGETT, Shelley
IPC分类号： C07K16/40 , C12N15/13 , C12N15/63 , A61K39/395
CPC分类号： C07K16/36 , A61K38/00 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/54 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： Human antibodies, or fragments thereof, to the gamma-carboxyglutamic acid (Gla) domain of factor IX and factor IXa, especially of human factor IX and human factor IXa. Isolated nucleic acid encoding said antibodies or fragments thereof. Methods for their preparation. Pharmaceutical composition comprising said antibodies or fragments thereof, and a method for treating a mammal by using said pharmaceutical composition in a therapeutically effective amount.
摘要翻译： 本发明提供了与因子IX（FIX）/因子IXa（IXa）反应的抗体的分离，鉴定，合成，表达和纯化。 在具体方面，本发明提供与人FIX Gla结构域反应的人类抗体。 本发明进一步提供组合物，特别是药物组合物，制品和抑制FIX活化和抑制FIX / IXa依赖性凝血的方法。
-
3.发明公开ANTI-PROSTATE STEM CELL ANTIGEN (PSCA) ANTIBODY COMPOSITIONS AND METHODS OF USE 有权抗前列腺干细胞抗原（PSCA）抗体定向及其用途
公开(公告)号：EP1226177A2
公开(公告)日：2002-07-31
申请号：EP00991385.6
申请日：2000-10-27
申请人： Genentech, Inc.
IPC分类号： C07K16/30 , C12N5/10 , C12N5/16 , C12N15/13 , C12N15/67 , A61K39/395 , A61K47/48 , A61K51/10
CPC分类号： C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/21 , C07K2317/24 , C07K2317/77 , C07K2319/00
摘要： The invention provides isolated anti-prostate stem cell antigen (PSCA) antibodies that internalize upon binding to PSCA on a mammalian in vivo. The invention also encompasses compositions comprising an anti-PSCA antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-PSCA antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-PSCA antibodies. The invention encompasses a method of producing the anti-PSCA antibodies. Other aspects of the invention are a method of killing a PSCA-expressing cancer cell, comprising contacting the cancer cell with an anti-PSCA antibody and a method of alleviating or treating a PSCA-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-PSCA antibody to the mammal.
-
公开(公告)号：EP1107996B1
公开(公告)日：2002-05-22
申请号：EP99943928.4
申请日：1999-08-26
申请人： Genentech, Inc.
发明人： ADAMS, Camellia, W. , DEVAUX, Brigitte , EATON, Dan, L. , HASS, Philip, E. , JUDICE, J., Kevin , KIRCHHOFER, Daniel , SUGGETT, Shelley
IPC分类号： C07K16/40 , C12N15/13 , C12N15/63 , A61K39/395
CPC分类号： C07K16/36 , A61K38/00 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/54 , C07K2317/622 , C07K2317/76 , C07K2317/92
-
公开(公告)号：EP1292680B1
公开(公告)日：2009-10-21
申请号：EP01950429.9
申请日：2001-06-22
申请人： Genentech, Inc.
IPC分类号： C12N15/13 , C07K16/28 , C12N5/10 , C12N15/63 , A61K39/395 , A61P25/00 , A61P25/28 , A61P9/00
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34
摘要： The invention concerns agonist anti-trkC monoclonal antoibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, including nerve cell damage associated with acute nervous cell system injury and chronic neurodegenerative diseases, including peripheral neuropathy.
-
6.发明授权ANTI-PROSTATE STEM CELL ANTIGEN (PSCA) ANTIBODY COMPOSITIONS AND METHODS OF USE 有权抗前列腺干细胞抗原（PSCA）抗体定向及其用途
公开(公告)号：EP1226177B1
公开(公告)日：2008-07-09
申请号：EP00991385.6
申请日：2000-10-27
申请人： GENENTECH, INC.
IPC分类号： C07K16/30 , C12N5/10 , C12N5/16 , C12N15/13 , C12N15/67 , A61K39/395 , A61K47/48 , A61K51/10
CPC分类号： C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/21 , C07K2317/24 , C07K2317/77 , C07K2319/00
摘要： The invention provides isolated anti-prostate stem cell antigen (PSCA) antibodies that internalize upon binding to PSCA on a mammalian in vivo. The invention also encompasses compositions comprising an anti-PSCA antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-PSCA antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-PSCA antibodies. The invention encompasses a method of producing the anti-PSCA antibodies. Other aspects of the invention are a method of killing a PSCA-expressing cancer cell, comprising contacting the cancer cell with an anti-PSCA antibody and a method of alleviating or treating a PSCA-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-PSCA antibody to the mammal.
-
公开(公告)号：EP1320549A2
公开(公告)日：2003-06-25
申请号：EP01975495.1
申请日：2001-09-26
申请人： Genentech, Inc.
发明人： DEVAUX, Brigitte , EBERHARD, David , GODDARD, Audrey , GODOWSKI, Paul, J. , GRIMALDI, J., Christopher , HILLAN, Kenneth, J. , WATANABE, Colin, K. , WOOD, William, I. , YANSURA, Daniel, G. , ZHANG, Zemin
IPC分类号： C07K14/705 , C12N15/00 , C07K19/00 , C07K16/28 , A61K38/17 , A61K39/395 , G01N33/577 , C12Q1/68
CPC分类号： C07K14/705 , A61K47/6455 , C07K16/30 , C07K16/40 , C12N9/0091
摘要： The present invention is directed to novel polypeptides Protein Upregulated in Metastatic Prostate Cancer (PUMPCn) and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.026 秒)
