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公开(公告)号：EP3309174A1
公开(公告)日：2018-04-18
申请号：EP17188907.4
申请日：2015-05-29
发明人： BOYD, Zachary , KOWANETZ, Marcin , ROCHE, Patrick C. , VENNAPUSA, Bharathi , ZHU, Yifei , LIAO, Zhiming , KOEPPEN, Hartmut
CPC分类号： C07K16/2827 , A61K39/3955 , A61K45/06 , A61N2005/1021 , C07K14/70532 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2319/30 , G01N33/53 , G01N33/57484 , G01N2500/10 , G01N2800/52
摘要： The invention provides programmed death-ligand 1 (PD-L1) antibodies and methods of using the same
摘要翻译： 本发明提供了程序性死亡配体1（PD-L1）抗体及其使用方法
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公开(公告)号：EP1318830A2
公开(公告)日：2003-06-18
申请号：EP01973141.3
申请日：2001-09-17
申请人： Genentech, Inc.
IPC分类号： A61K38/17 , A61K39/395 , G01N33/574 , C12Q1/68 , G01N33/50 , A61P13/08 , A61P35/00
CPC分类号： G01N33/57434 , A61K38/177 , A61K2039/505 , G01N2333/705 , G01N2500/00
摘要： The present invention is directed to methods of alleviating prostate disorders by activation of the Notch1 receptor. Also provided herein are methods for detecting and diagnosing prostate disorders, wherein the specific disorder is prostate cancer.
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4.发明授权ANTI-PROSTATE STEM CELL ANTIGEN (PSCA) ANTIBODY COMPOSITIONS AND METHODS OF USE 有权抗前列腺干细胞抗原（PSCA）抗体定向及其用途
公开(公告)号：EP1226177B1
公开(公告)日：2008-07-09
申请号：EP00991385.6
申请日：2000-10-27
申请人： GENENTECH, INC.
IPC分类号： C07K16/30 , C12N5/10 , C12N5/16 , C12N15/13 , C12N15/67 , A61K39/395 , A61K47/48 , A61K51/10
CPC分类号： C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/21 , C07K2317/24 , C07K2317/77 , C07K2319/00
摘要： The invention provides isolated anti-prostate stem cell antigen (PSCA) antibodies that internalize upon binding to PSCA on a mammalian in vivo. The invention also encompasses compositions comprising an anti-PSCA antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-PSCA antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-PSCA antibodies. The invention encompasses a method of producing the anti-PSCA antibodies. Other aspects of the invention are a method of killing a PSCA-expressing cancer cell, comprising contacting the cancer cell with an anti-PSCA antibody and a method of alleviating or treating a PSCA-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-PSCA antibody to the mammal.
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5.发明公开ACHAETE-SCUTE LIKE-2 POLYPEPTIDES AND ENCODING NUCLEIC ACIDS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR 审中-公开Achaete-盾样2种多肽和编码核酸和方法进行诊断和治疗肿瘤
公开(公告)号：EP1575515A2
公开(公告)日：2005-09-21
申请号：EP03791556.8
申请日：2003-06-04
申请人： GENENTECH, INC.
发明人： BALDWIN, Daryl , CLARK, Hilary , JUBB, Adrian , KOEPPEN, Hartmut , QUAN, Clifford , WU, Thomas, D. , ZHANG, Zemin
IPC分类号： A61K6/00
CPC分类号： C07K14/4748 , C07K14/47 , C07K14/82
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：EP1833996B1
公开(公告)日：2012-12-05
申请号：EP06733637.0
申请日：2006-01-05
申请人： Genentech, Inc.
发明人： JUBB, Adrian, M. , KOEPPEN, Hartmut
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118
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7.发明公开
公开(公告)号：EP1696963A2
公开(公告)日：2006-09-06
申请号：EP04815573.3
申请日：2004-12-21
申请人： GENENTECH, INC.
发明人： CHANG, Wesley , DE SAUVAGE, Frederic , EATON, Dan L. , EBENS, JR., Allen J. , FRANTZ, Gretchen , HONGO, Jo-Anne S. , KOEPPEN, Hartmut , POLSON, Andrew , SMITH, Victoria
IPC分类号： A61K47/48
CPC分类号： C07K16/3061 , A61K47/6803 , A61K47/6867 , A61K2039/505 , C07K14/705
摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same
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公开(公告)号：EP1409549A2
公开(公告)日：2004-04-21
申请号：EP02747926.0
申请日：2002-06-19
申请人： Genentech, Inc.
发明人： CAIRNS, Belinda , CHEN, Ruihuan , FRANTZ, Gretchen , HILLAN, Kenneth, J. , KOEPPEN, Hartmut , PHILLIPS, Heidi, S. , POLAKIS, Paul , SMITH, Victoria , SPENSER, Susan, D. , WILLIAMS, P., Mickey , WU, Thomas, D. , ZHANG, Zemin
IPC分类号： C07K16/18 , C07K16/30 , G01N33/574
CPC分类号： C07K16/18 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K16/30 , C07K16/3023 , C07K16/40 , C07K2317/73 , G01N33/57407
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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9.发明公开ANTI-PROSTATE STEM CELL ANTIGEN (PSCA) ANTIBODY COMPOSITIONS AND METHODS OF USE 有权抗前列腺干细胞抗原（PSCA）抗体定向及其用途
公开(公告)号：EP1226177A2
公开(公告)日：2002-07-31
申请号：EP00991385.6
申请日：2000-10-27
申请人： Genentech, Inc.
IPC分类号： C07K16/30 , C12N5/10 , C12N5/16 , C12N15/13 , C12N15/67 , A61K39/395 , A61K47/48 , A61K51/10
CPC分类号： C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/21 , C07K2317/24 , C07K2317/77 , C07K2319/00
摘要： The invention provides isolated anti-prostate stem cell antigen (PSCA) antibodies that internalize upon binding to PSCA on a mammalian in vivo. The invention also encompasses compositions comprising an anti-PSCA antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-PSCA antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-PSCA antibodies. The invention encompasses a method of producing the anti-PSCA antibodies. Other aspects of the invention are a method of killing a PSCA-expressing cancer cell, comprising contacting the cancer cell with an anti-PSCA antibody and a method of alleviating or treating a PSCA-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-PSCA antibody to the mammal.
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10.发明公开
公开(公告)号：EP4323951A1
公开(公告)日：2024-02-21
申请号：EP22725948.8
申请日：2022-04-14
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