公开(公告)号：EP2152755A1

公开(公告)日：2010-02-17

申请号：EP08756130.4

申请日：2008-05-22

申请人： Genentech, Inc.

发明人： HASS, Philip ,  JIANPING, Yin ,  KATSCHKE, Kenneth, Jr. ,  STEFFEK, Micah ,  WIESMANN, Christian ,  VAN LOOKEREN CAMPAGNE, Menno

IPC分类号： C07K16/40 ,  C12N9/64 ,  A61P27/02 ,  A61P37/00 ,  A61K39/395

CPC分类号： C07K16/40 ,  A61K9/0048 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  Y10S435/975

摘要： The invention concerns the prevention and treatment of complement-associated eye conditions, such as choroidal neovascularization (CNV) and age-related macular degeneration (AMD), by administration of Factor D antagonists.

公开(公告)号：EP2024391A2

公开(公告)日：2009-02-18

申请号：EP07852376.8

申请日：2007-05-30

申请人： Genentech, Inc.

发明人： HASS, Phillip ,  KATSCHKE, Kenneth, Jr. ,  STEFFEK, Micah ,  VAN LOOKEREN CAMPAGNE, Menno ,  WIESMANN, Christian ,  YIN, Jianping

IPC分类号： C07K14/705 ,  C30B7/00 ,  G01N23/20 ,  G06F19/00

CPC分类号： C07K14/70503 ,  C07K2299/00 ,  C07K2319/30 ,  C30B7/00 ,  G01N33/6863

摘要： The present invention concerns determination of the crystal structure of the macrophage specific receptor, CRIg (earlier referred to as STIgMA), and its complex with the C3b and C3c subunits of complement C3 (C3b:CRIg and C3c:CRIg complexes). The invention further concerns the use of the crystal structure of CRIg or the C3b:CRIg complex to screen for and identify molecules structurally and/or functionally related to CRIg, including CRIg agonists and antagonists.