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公开(公告)号：EP3242872B1
公开(公告)日：2019-07-03
申请号：EP16702830.7
申请日：2016-01-08
发明人： ALBRECHT,Brian, K. , COTE, Alexandre , GEHLING, Victor , HSIAO-WEI TSUI, Vickie , KIEFER, James, Richard, Jr. , LIANG, Jun , MAGNUSON, Steven , NASVESCHUK, Christopher, G. , PASTOR, Richard , ROMERO, F. Anthony , TAYLOR, Alexander, M. , ZHANG, Birong
IPC分类号： C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D241/04 , C07D211/30 , A61K31/44 , A61K31/444 , A61K31/4439 , A61K31/4433 , A61K31/4436 , A61K31/495 , A61P35/00 , A61P35/02 , A61P31/04
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2.发明公开4,5-DIHYDROIMIDAZOLE DERIVATIVES AND THEIR USE AS HISTONE DEMETHYLASE (KDM2B) INHIBITORS 审中-公开4,5-二氢咪唑衍生物及其作为组蛋白激酶二甲基化酶（KDM2B）抑制剂的用途
公开(公告)号：EP3242875A1
公开(公告)日：2017-11-15
申请号：EP16702999.0
申请日：2016-01-08
发明人： ALBRECHT, Brian, K. , COTE, Alexandre , GEHLING, Victor , HSIAO-WEI TSUI, Vickie , KIEFER, James, Richard, Jr. , LIANG, Jun , MAGNUSON, Steven , NASVESCHUK, Christopher, G. , ROMERO, F. Anthony , TAYLOR, Alexander, M.
IPC分类号： C07D403/12 , C07D233/44 , C07D401/04 , C07D235/02 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/08 , A61K31/454 , A61K31/496 , A61K31/4995 , A61P35/00
CPC分类号： C07D233/44 , C07D235/02 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/08
摘要： The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM2b. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：EP3218374A1
公开(公告)日：2017-09-20
申请号：EP15797572.3
申请日：2015-11-10
发明人： ALBRECHT, Brian K. , BELLON, Steven F. , BURDICK, Daniel J. , COTE, Alexandre , CRAWFORD, Terry , DAKIN, Les A. , HEWITT, Michael Charles , HSIAO-WEI TSUI, Vickie , LEBLANC, Yves , MAGNUSON, Steven R. , NASVESCHUK, Christopher G. , ROMERO, F. Anthony , TANG, Yong , TAYLOR, Alexander M. , WANG, Shumei
IPC分类号： C07D471/04 , A61K31/407 , A61P35/00 , A61P37/00 , C07D519/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K45/06 , C07D519/00
摘要： and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
摘要翻译： 本发明涉及式（I）化合物及其盐，其中R 1，R 2和Q具有本说明书中定义的任何值，及其组合物和用途。 这些化合物可用作溴结构域的抑制剂。 还包括包含式（I）化合物或其药学上可接受的盐的药物组合物，以及使用该化合物和盐治疗各种溴结构域介导的病症的方法。
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公开(公告)号：EP3218376B1
公开(公告)日：2019-12-25
申请号：EP15801563.6
申请日：2015-11-10
发明人： ALBRECHT, Brian K. , BELLON, Steven F. , BURDICK, Daniel J. , COTE, Alexandre , CRAWFORD, Terry , DAKIN, Les A. , HSIAO-WEI TSUI, Vickie , HEWITT, Michael Charles , LEBLANC, Yves , MAGNUSON, Steven R. , NASVESCHUK, Christopher G. , ROMERO, F., Anthony , TANG, Yong , TAYLOR, Alexander M. , WANG, Shumei
IPC分类号： C07D471/04 , C07D519/00
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公开(公告)号：EP3218375A1
公开(公告)日：2017-09-20
申请号：EP15797766.1
申请日：2015-11-10
发明人： ALBRECHT, Brian K. , BELLON, Steven F. , BURDICK, Daniel J. , COTE, Alexandre , CRAWFORD, Terry , DAKIN, Les, A. , HEWITT, Michael, Charles , HSIAO-WEI TSUI, Vickie , LEBLANC, Yves , MAGNUSON, Steven, R. , NASVESCHUK, Christopher, G. , ROMERO, F., Anthony , TANG, Yong , TAYLOR, Alexander, M. , WANG, Shumei
IPC分类号： C07D471/04 , A61K31/407 , A61P35/00 , A61P37/00
CPC分类号： A61K31/40 , C07D471/04
摘要： and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
摘要翻译： 本发明涉及式（I）化合物及其盐，其中R 1，R 2和Q具有本说明书中定义的任何值，及其组合物和用途。 这些化合物可用作溴结构域的抑制剂。 还包括包含式（I）化合物或其药学上可接受的盐的药物组合物，以及使用该化合物和盐治疗各种溴结构域介导的病症的方法。
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6.发明公开(PIPERIDIN-3-YL)(NAPHTHALEN-2-YL)METHANONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HISTONE DEMETHYLASE KDM2B FOR THE TREATMENT OF CANCER 审中-公开（PIPERIDIN-3-YL）（萘-2-基）甲酮衍生物及作为用于治疗癌症的组蛋白激酶二甲基化酶KDM2B抑制剂的相关化合物
公开(公告)号：EP3242872A1
公开(公告)日：2017-11-15
申请号：EP16702830.7
申请日：2016-01-08
发明人： ALBRECHT,Brian, K. , COTE, Alexandre , GEHLING, Victor , HSIAO-WEI TSUI, Vickie , KIEFER, James, Richard, Jr. , LIANG, Jun , MAGNUSON, Steven , NASVESCHUK, Christopher, G. , PASTOR, Richard , ROMERO, F. Anthony , TAYLOR, Alexander, M. , ZHANG, Birong
IPC分类号： C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D241/04 , C07D211/30 , A61K31/44 , A61K31/444 , A61K31/4439 , A61K31/4433 , A61K31/4436 , A61K31/495 , A61P35/00 , A61P35/02 , A61P31/04
CPC分类号： C07D401/06 , C07D211/30 , C07D241/04 , C07D405/06 , C07D409/06 , C07D413/06
摘要： The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM2b. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：EP3218376A1
公开(公告)日：2017-09-20
申请号：EP15801563.6
申请日：2015-11-10
发明人： ALBRECHT, Brian K. , BELLON, Steven F. , BURDICK, Daniel J. , COTE, Alexandre , CRAWFORD, Terry , DAKIN, Les A. , HSIAO-WEI TSUI, Vickie , HEWITT, Michael Charles , LEBLANC, Yves , MAGNUSON, Steven R. , NASVESCHUK, Christopher G. , ROMERO, F. Anthony , TANG, Yong , TAYLOR, Alexander M. , WANG, Shumei
IPC分类号： C07D471/04 , C07D519/00
摘要： and to salts thereof, wherein R1, R2, Rc, and Rd have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
摘要翻译： 本发明涉及式（I）的化合物：[其中R 1，R 2，R c和R d具有本说明书中定义的任何值，及其组合物和用途，其中R 1，R 2，R c和R d为氢。 这些化合物可用作溴结构域的抑制剂。 还包括包含式（I）化合物或其药学上可接受的盐的药物组合物，以及使用该化合物和盐治疗各种溴结构域介导的病症的方法。
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