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1.发明公开KNOCKOUT MICE FOR DIFFERENT GENES AND THEIR USE FOR GENE CHARACTERIZATION 审中-公开对于不同的基因敲除小鼠和它们用于GENKENNZEICHNUNG
公开(公告)号：EP2046965A2
公开(公告)日：2009-04-15
申请号：EP07863348.4
申请日：2007-05-21
发明人： DESAUVAGE, Frederic , FILVAROFF, Ellen , JUNUTULA, Jagath, Reddy , PAYNE, Bobby, Joe , SHI, Zheng-zheng , SPARKS, Mary Jean , VOGEL, Peter
IPC分类号： C12N15/85 , A01K67/027 , G01N33/53 , C07K14/47 , C07K16/18
CPC分类号： G01N33/5088 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/035 , C07K14/47 , C12N15/8509 , G01N33/6893 , G01N2500/00
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO844, PRO1131 or PRO5992 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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2.发明公开ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE 有权免疫球蛋白免疫球蛋白抗体CD79B-ANTIKÖRPERSOWIE VERFAHREN ZU IHRER VERWENDUNG
公开(公告)号：EP2247620A1
公开(公告)日：2010-11-10
申请号：EP09707473.6
申请日：2009-01-14
申请人： Genentech, Inc.
发明人： CHEN, Yvonne , DENNIS, Mark , DORNAN, David , ELKINS, Kristi , JUNUTULA, Jagath, Reddy , POLSON, Andrew , ZHENG, Bing
IPC分类号： C07K16/28 , A61K39/395 , C12N15/13 , A61K47/48 , A61P35/00
CPC分类号： C07K16/2803 , A61K31/537 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6849 , A61K47/6867 , A61K51/1027 , A61K2039/505 , C07K16/3061 , C07K2317/24 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92 , G01N33/57492 , Y02A50/412 , Y02A50/423
摘要： The present invention is directed to humanized and conjugated antibodies against CD79b useful for the treatment of hematopoietic tumor in mammals and to methods of using those antibodies for the same.
摘要翻译： 本发明涉及可用于治疗哺乳动物造血肿瘤的CD79b的人源化和缀合抗体以及使用这些抗体的方法。
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3.发明授权
公开(公告)号：EP2247620B1
公开(公告)日：2016-05-18
申请号：EP09707473.6
申请日：2009-01-14
申请人： Genentech, Inc.
发明人： CHEN, Yvonne , DENNIS, Mark , DORNAN, David , ELKINS, Kristi , JUNUTULA, Jagath, Reddy , POLSON, Andrew , ZHENG, Bing
IPC分类号： A61K51/10 , C07K16/28 , A61K39/395 , C12N15/13 , A61K47/48 , A61P35/00 , A61K39/00 , G01N33/574 , A61K38/05 , A61K31/537
CPC分类号： C07K16/2803 , A61K31/537 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6849 , A61K47/6867 , A61K51/1027 , A61K2039/505 , C07K16/3061 , C07K2317/24 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92 , G01N33/57492 , Y02A50/412 , Y02A50/423
摘要： The present invention is directed to humanized and conjugated antibodies against CD79b useful for the treatment of hematopoietic tumor in mammals and to methods of using those antibodies for the same.
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4.发明授权
公开(公告)号：EP2209808B1
公开(公告)日：2014-01-15
申请号：EP08839947.2
申请日：2008-10-16
申请人： Genentech, Inc.
CPC分类号： C07K16/28 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K47/6851 , A61K47/6869 , A61K47/6889 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/40 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/73 , C07K2317/77 , G01N33/574 , G01N33/57492
摘要： Cysteine engineered anti-TENB2 antibodies are engineered by replacing one or more amino acids of a parent anti-TENB2 antibody with non cross-linked, reactive cysteine amino acids. Methods of design, preparation, screening, and selection of the cysteine engineered anti-TENB2 antibodies are provided. Cysteine engineered anti-TENB2 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-TENB2 antibody-drug conjugates having Formula I: Ab-(L-D)p I where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.
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公开(公告)号：EP2209808A1
公开(公告)日：2010-07-28
申请号：EP08839947.2
申请日：2008-10-16
申请人： Genentech, Inc.
CPC分类号： C07K16/28 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K47/6851 , A61K47/6869 , A61K47/6889 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/40 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/73 , C07K2317/77 , G01N33/574 , G01N33/57492
摘要： Cysteine engineered anti-TENB2 antibodies are engineered by replacing one or more amino acids of a parent anti-TENB2 antibody with non cross-linked, reactive cysteine amino acids. Methods of design, preparation, screening, and selection of the cysteine engineered anti-TENB2 antibodies are provided. Cysteine engineered anti-TENB2 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-TENB2 antibody-drug conjugates having Formula I: Ab-(L-D)p I where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.
摘要翻译： 其中p为1至4.公开了半胱氨酸改造的抗体药物化合物和组合物的诊断和治疗用途。
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公开(公告)号：EP2176296B1
公开(公告)日：2012-02-01
申请号：EP08781859.7
申请日：2008-07-15
申请人： Genentech, Inc.
发明人： CHEN, Yvonne , DENNIS, Mark , DORNAN, David , ELKINS, Kristi , JUNUTULA, Jagath, Reddy , POLSON, Andrew , ZHENG, Bing
IPC分类号： C07K16/28 , A61K39/395 , C12N15/13 , A61K47/48 , A61P35/00
CPC分类号： C07K16/2896 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2803 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y02A50/412
摘要： The present invention is directed to humanized and conjugated antibodies against CD79b useful for the treatment of hematopoietic tumor in mammals and to methods of using those antibodies for the same.
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7.发明公开
公开(公告)号：EP2247312A2
公开(公告)日：2010-11-10
申请号：EP09707533.7
申请日：2009-01-13
申请人： Genentech, Inc.
发明人： CROWLEY, Craig , DESAUVAGE, Frederic, J. , EATON, Dan, L. , EBENS, Allen, Jr. , ELKINS, Kristi , HONGO, Jo-Anne, S. , JUNUTULA, Jagath, Reddy , POLSON, Andrew , ROSS, Sarajane , SMITH, Victoria , VANDLEN, Richard, L. , ZHENG, Bing
CPC分类号： C07K16/2803 , A61K38/00 , A61K47/6817 , A61K47/6851 , A61K2039/505 , C07K14/705 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/624 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：EP2176296A1
公开(公告)日：2010-04-21
申请号：EP08781859.7
申请日：2008-07-15
申请人： Genentech, Inc.
发明人： CHEN, Yvonne , DENNIS, Mark , DORNAN, David , ELKINS, Kristi , JUNUTULA, Jagath, Reddy , POLSON, Andrew , ZHENG, Bing
IPC分类号： C07K16/28 , A61K39/395 , C12N15/13 , A61K47/48 , A61P35/00
CPC分类号： C07K16/2896 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2803 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y02A50/412
摘要： The present invention is directed to humanized and conjugated antibodies against CD79b useful for the treatment of hematopoietic tumor in mammals and to methods of using those antibodies for the same.
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