公开(公告)号：EP3176579A1

公开(公告)日：2017-06-07

申请号：EP16200924.5

申请日：2016-11-28

申请人： General Electric Company

发明人： KARP, Jessica Godin ,  CHEN, Xiaohui ,  SHAIKH, Kashan Ali ,  WANG, Mengli ,  LENIGK, Ralf ,  SURRETTE, Christine Lynne

IPC分类号： G01N33/49

CPC分类号： G01N33/5002 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502761 ,  B01L3/502769 ,  B01L2200/0647 ,  B01L2300/16 ,  C12Q1/24 ,  G01N33/491

摘要： A device 100 and/or methodology are described that include a mechanism for separating erythrocytes 110 from other constituents of blood and for purifying leukocytes 102 from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes 110 (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device 100 or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.

摘要翻译： 描述了一种装置100和/或方法，其包括用于从血液的其它成分分离红细胞110并用于从血液净化白细胞102的机制。 分离和纯化方面可以在单独的组分中或同一组分内提供。 分离方面有助于将红细胞110（红细胞）与血液中的其它细胞分离，例如通过红细胞的聚集。 合适的聚集装置100或装置部件使用具有至少一个小尺寸的腔室（例如，微流体芯片）来控制血液与含有高分子量聚合物（例如葡聚糖）的溶液的相互作用以实现分离。

公开(公告)号：EP2791506A1

公开(公告)日：2014-10-22

申请号：EP12808777.2

申请日：2012-12-13

申请人： General Electric Company

发明人： PULEO, Christopher, M. ,  KEIMEL, Christopher, Fred ,  CHEN, Xiaohui ,  LENIGK, Ralf ,  GALLIGAN, Craig, Patrick ,  MILLER, Todd, Frederick

IPC分类号： F04B19/00 ,  A61K9/00 ,  B01D61/42

CPC分类号： F04B19/006 ,  A61M1/0068 ,  A61M2005/14513

摘要： An electroosmotic pump comprises a plurality of membranes comprising one or more positive electroosmotic membranes and one or more negative electroosmotic membranes, a plurality of electrodes comprising cathodes and anodes, and a power source. Each of the positive electroosmotic membranes and negative electroosmotic membranes are disposed alternately and wherein at least one of the cathodes is disposed on one side of one of the membranes and at least one of the anodes is disposed on other side of the membrane. At least one of the cathodes or anodes is disposed between a postive electroosmotic membrane and negative electroosmotic membrane. The pump can be used to actuate a valve, or can be precharged, duch that an external power source is not required.

公开(公告)号：EP2702144A1

公开(公告)日：2014-03-05

申请号：EP12776983.4

申请日：2012-04-27

申请人： General Electric Company

发明人： KHAN, Zaeem, A. ,  DULGAR-TULLOCH, Aaron ,  RAKUFF, Stefan ,  SHOEMAKER, Philip, Alexander ,  KVAM, Eric, L. ,  CHEN, Xiaohui ,  ROY, Jaydeep

IPC分类号： C12N5/0775 ,  C12M3/08

CPC分类号： C12M45/09 ,  B01F5/0057 ,  B01F5/0206 ,  B01F5/0231 ,  B01F5/0256 ,  B01F5/10 ,  C12M27/00 ,  C12M47/04 ,  C12N5/0653 ,  C12N2501/70 ,  C12N2501/734 ,  C12N2521/00

摘要： A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer; introducing the adipose tissue into the vessel; introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.