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    POROUS MEMBRANES WITH A POLYMER GRAFTING, METHODS AND USES THEREOF
    4.
    发明公开
    POROUS MEMBRANES WITH A POLYMER GRAFTING, METHODS AND USES THEREOF 审中-公开
    具有聚合物接枝的多孔膜，方法和用途

    公开(公告)号：EP3221698A1

    公开(公告)日：2017-09-27

    申请号：EP15802003.2

    申请日：2015-11-18

    申请人： General Electric Company

    发明人： LI, Bing ,  BALES, Brian Christopher ,  MOORE, David Roger ,  NICHOLS, Jason Michael ,  OLSEN, Cathryn Ellen ,  ALBERTS, William Christopher ,  MONDELLO, Frank John

    IPC分类号： G01N33/543 ,  B01D67/00 ,  B01D69/14

    CPC分类号： G01N33/548 ,  B01D67/009 ,  B01D69/144 ,  B01D71/78 ,  G01N33/54353 ,  Y02A50/57

    摘要： A modified porous membrane comprising a polymer coating grafted to a porous membrane is described. A method for analyte detection from a biological sample using an immunoassay is also provided using the modified membrane, wherein the method comprises a) providing a modified porous membrane having the structure of Formula (I), b) incubating the modified porous membrane with a first biomolecule, wherein the first biomolecule binds to the modified porous membrane to form a first biomolecule bound modified porous membrane; and c) adding a biological sample comprising at least an analyte to the first biomolecule bound modified porous membrane for analyte detection by binding the analyte to the first biomolecule bound to the modified porous membrane.

    摘要翻译： 描述了包含接枝到多孔膜上的聚合物涂层的改性多孔膜。 还提供了使用免疫测定法使用免疫测定法从生物样品中分析物检测的方法，其中该方法包括a）提供具有式（I）结构的改性多孔膜，b）将改性多孔膜与第一 其中所述第一生物分子结合所述改性多孔膜以形成第一生物分子结合改性多孔膜; 和c）通过将分析物结合到与修饰的多孔膜结合的第一生物分子上，将包含至少一种分析物的生物样品加入到用于分析物检测的第一生物分子结合的改性多孔膜上。

    POROUS MEMBRANES HAVING A POLYMERIC COATING AND METHODS FOR THEIR PREPARATION AND USE
    5.
    发明公开
    POROUS MEMBRANES HAVING A POLYMERIC COATING AND METHODS FOR THEIR PREPARATION AND USE 审中-公开
    随着对生产和使用的聚合物涂层和方法多孔膜

    公开(公告)号：EP2797680A1

    公开(公告)日：2014-11-05

    申请号：EP12863951.5

    申请日：2012-12-27

    申请人： General Electric Company

    发明人： LI, Bing ,  OLSEN, Cathryn Ellen ,  MOORE, David Roger

    IPC分类号： B01D71/06 ,  B01D67/00

    CPC分类号： G01N33/54353 ,  B01D67/009 ,  B01D67/0093 ,  B01D69/144 ,  B01D71/20 ,  B01D2323/38

    摘要： A modified porous membrane comprising a polymer coating grafted to a porous membrane is described. The polymer coatings grafted to the porous membranes generally comprise a polymer of variable length of an electron beam (e-beam) reactive moiety, designated "poly-(A)x," a linkage group that forms a bond between the between the poly-(A)x, and a functional B group available to react with a chemical group on a biomolecule, wherein the polymer coating on the porous membrane facilitates the immobilization of a biomolecule, such as DNA, RNA, a protein, and an antibody, on the porous membrane. The compositions find use in immunoassays, in vitro diagnostic tests, point of care tests, techniques for the isolation of a biomolecule from a biological sample, and other methods that require the immobilization of a biomolecule on a porous membrane. Methods of making these modified porous membranes are also disclosed.