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1.发明授权
公开(公告)号：EP2911759B1
公开(公告)日：2024-07-17
申请号：EP13789418.4
申请日：2013-10-23
CPC classification number: B01D15/3847 , C07K1/165 , B01D15/426 , A61B50/00 , A61B50/30
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公开(公告)号：EP3298129B1
公开(公告)日：2024-05-01
申请号：EP16800805.0
申请日：2016-05-27
CPC classification number: A61K35/00 , B01D15/3804 , B01D15/3847 , B01J20/048 , B01J20/20 , B01J20/28038 , B01J20/28004 , B01J20/28057 , B01D15/20 , B01D15/34 , A61P7/00
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公开(公告)号：EP2970948B1
公开(公告)日：2018-12-26
申请号：EP14709704.2
申请日：2014-03-13
Applicant: GlaxoSmithKline Biologicals SA
Inventor： BERLANDA SCORZA, Francesco , WEN, Yingxia , GEALL, Andrew , PORTER, Frederick
CPC classification number: C07H21/02 , B01D15/36 , B01D15/38 , B01D15/3847 , B01D61/14 , B01D2015/3838 , C07H1/06 , C12N15/101 , C12N15/1017
Abstract: Methods for purifying RNA from a sample, comprising one or more steps of tangential flow filtration, hydroxyapatite chromatography, core bead flow-through chromatography, or any combinations thereof. These techniques are useful individually, but show very high efficiency when used in combination, or when performed in particular orders. The methods can purify RNA in a highly efficient manner without unduly compromising potency or stability, to provide compositions in which RNA is substantially cleared of contaminants. Moreover, they can be performed without the need for organic solvents.
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公开(公告)号：EP3353193A1
公开(公告)日：2018-08-01
申请号：EP16849398.9
申请日：2016-09-19
Applicant: Sanofi Pasteur Biologics, LLC
Inventor： MUNDLE, Sophia, Tara
IPC: C07K14/135 , C12N7/02 , C12N15/45
CPC classification number: C12N7/00 , A61K35/76 , A61K47/26 , B01D15/34 , B01D15/3847 , B01D61/145 , B01D63/02 , B01D71/68 , C12N2760/00021 , C12N2760/00051 , C12N2760/00064
Abstract: Disclosed herein are methods for the purification of Respiratory Syncytial Virus (RSV) particles from a host cell culture comprising treating the host cell culture with an endonuclease, filtering the material to remove cellular debris and/or aggregated material, applying the material to a core bead chromatography resin, and recovering the purified RSV particles. Also disclosed herein are pharmaceutical compositions comprising purified RSV.
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公开(公告)号：EP3298129A1
公开(公告)日：2018-03-28
申请号：EP16800805.0
申请日：2016-05-27
Applicant: Immutrix Therapeutics, Inc.
Inventor： RAE, Carol A. , SIMONI, Jan S. , MOELLER, John F.
CPC classification number: B01D15/20 , A61K35/00 , A61K35/14 , B01D15/34 , B01D15/3804 , B01D15/3847 , B01J20/048 , B01J20/20 , B01J20/28004 , B01J20/28038 , B01J20/28057
Abstract: A method of preparing a universal blood product comprising obtaining a blood product; contacting the blood product with (i) hydroxyapatite; (ii) a carbonaceous material comprising at least a mixture of a first carbon particle having macroporous size α and a second carbon particle having macroporous size β; and (iii) at least one support matrix chemically associated with an antigenic determinant.to form a cleansed product; and recovering the cleansed product. A method of preparing a universal blood product comprising obtaining a blood product; contacting the blood product with (i) hydroxyapatite; (ii) a carbonaceous material comprising at least a mixture of a first carbon particle having macroporous size α and a second carbon particle having macroporous size β; and (iii) at least one support matrix chemically associated with an antigenic determinant.to form a cleansed product; wherein at least one of the hydroxyapatite, carbonaceous material and support matrix is functionalized.
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Patent Agency Ranking6.发明授权
公开(公告)号：EP3040346B1
公开(公告)日：2018-02-28
申请号：EP16156518.9
申请日：2011-03-30
Applicant: Octapharma AG
Inventor： Winge, Stefan , Gilljam, Gustav , Tiemeyer, Maya
IPC: C07K14/475 , C07K14/52 , C07K14/535 , C07K14/575 , B01D15/36 , C07K1/18 , C07K1/36
CPC classification number: C07K14/535 , B01D15/34 , B01D15/362 , B01D15/3828 , B01D15/3847 , C07K1/165 , C07K1/36 , C07K14/475 , C07K14/52 , C07K14/575 , B01D15/327
Abstract: A process of purifying G-CSF (Granulocyte Colony Stimulating Factor) in a purification sequence employing chromatography characterized in that - at least one chromatography is performed using a multimodal resin containing a negatively charged 2-(benzoylamino) butanoic acid ligand - G-CSF binds to the multimodal resin at a pH between 4 to 6.2, and - the G-CSF is eluting at a pH 5.5 to 6.5 and wherein the elution is performed with arginine having a concentration in the range of from 0.1 M to 2.0 M, - optionally in combination with an affinity ligand chromatography step employing a yeast derived F ab fragment directed towards the G-CSF.
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公开(公告)号：EP3141894A4
公开(公告)日：2017-11-15
申请号：EP15789114
申请日：2015-03-19
Applicant: SHOWA DENKO KK
Inventor： KONDO HIDEYUKI , SASUGA JUNJI , SHUKUYA TAKAYUKI
CPC classification number: G01N30/52 , B01D15/363 , B01D15/3847 , G01N27/62 , G01N30/02 , G01N30/26 , G01N30/56 , G01N30/6052 , G01N30/72 , G01N30/7233 , G01N30/88 , G01N30/96 , B01D15/305
Abstract: A mass spectrometry method by a liquid chromatograph-mass spectrometer that can detect an organic acid with high sensitivity by retaining, separating and eluting the organic acid without adding any nonvolatile substance to a mobile phase and without receiving any restriction of a ratio of a water-soluble organic solvent, and an analytical column are provided. The mass spectrometry method is a mass spectrometry method for an organic acid by a liquid chromatograph-mass spectrometer, wherein a column packed with a hydrophilic polymer having an anion-exchange group is used, and as a mobile phase, a water-soluble organic solvent-water mixed solution is used. The analytical column is a column for liquid chromatography for an organic acid, in which a polyether ether ketone (PEEK) resin housing for liquid chromatography is packed with a hydrophilic polymer having an anion-exchange group.
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公开(公告)号：EP2773438B1
公开(公告)日：2017-06-14
申请号：EP12845437.8
申请日：2012-11-02
Applicant: F. Hoffmann-La Roche AG
Inventor： NADARAJAH, Deepa , MEHTA, Amit
IPC: B01D15/32 , B01D15/14 , B01D15/36 , C07K1/22 , C07K16/06 , B01D15/38 , C07K16/00 , C07K1/16 , C07K1/18 , B01D15/42
CPC classification number: C07K16/00 , B01D15/14 , B01D15/327 , B01D15/363 , B01D15/3804 , B01D15/3847 , B01D15/424 , C07K1/16 , C07K1/165 , C07K1/18 , C07K1/22
Abstract: The present invention provides methods for purifying a polypeptide from a composition comprising the polypeptide and at least one contaminant by overloading a chromatography material and eluting the product.
Abstract translation: 本发明提供了从包含多肽和至少一种污染物的组合物中纯化多肽的方法，其通过使色谱材料过载并洗脱该产物。
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公开(公告)号：EP2575847B1
公开(公告)日：2017-06-14
申请号：EP11787363.8
申请日：2011-05-25
Applicant: F. Hoffmann-La Roche AG
Inventor： LIU, Hui, F. , KELLEY, Brian, David , MYERS, Deanna, E. , MCCOOEY, Beth , PETTY, Krista, Marie
CPC classification number: C07K1/18 , B01D15/362 , B01D15/3847 , C07K1/165 , G01N2030/8831
Abstract: The present invention provides methods for purifying a polypeptide from a composition comprising the polypeptide and at least one contaminant and formulations comprising the polypeptide purified by the methods. The methods for purifying include cation exchange material and/or mixed mode material.
Abstract translation: 本发明提供了用于从包含多肽和至少一种污染物的组合物纯化多肽的方法以及包含通过所述方法纯化的多肽的制剂。 纯化方法包括阳离子交换材料和/或混合模式材料。
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10.发明公开
公开(公告)号：EP3171888A1
公开(公告)日：2017-05-31
申请号：EP15824392.3
申请日：2015-07-16
Applicant: Merck Sharp & Dohme Corp.
CPC classification number: C07K14/62 , B01D15/1878 , B01D15/327 , B01D15/363 , B01D15/3847 , C07K1/18 , C07K1/20
Abstract: A process is described for purifying insulin and insulin analogs that comprises use of two or more orthogonal chromatographic purification steps in tandem following enzymatic digestion of the propeptide-insulin precursor to remove specific product impurities, improve process consistency, and increase process redundancy in the purification of the insulin or insulin analog, e.g., insulin lispro.
Abstract translation: 描述了用于纯化胰岛素和胰岛素类似物的方法，其包括在前肽 - 胰岛素前体的酶促消化之后串联使用两个或更多个正交色谱纯化步骤以去除特定产物杂质，提高过程一致性并增加纯化 胰岛素或胰岛素类似物，例如赖脯胰岛素。
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