专利检索 ap:("Genetics Institute, LLC" OR "Novartis Vaccines AND Diagnostics, Inc.") AND inv:"BARR, Philip, J." 第 1 页

1.

发明授权
EXPRESSION OF PACE IN HOST CELLS AND METHODS OF USE THEREOF 失效
标题翻译： PACE在宿主细胞中的表达和方法的使用

公开(公告)号：EP0574402B2

公开(公告)日：2012-08-01

申请号：EP92901535.2

申请日：1991-11-26

申请人： Genetics Institute, LLC , Novartis Vaccines and Diagnostics, Inc.

发明人： BARR, Philip, J. , BRAKE, Anthony, J. , KAUFMAN, Randal, J. 111 Marlborough Street , TEKAMP-OLSON, Patricia , WASLEY, Louise , WONG, Polly, A.

IPC分类号： C12N15/52 , C12N15/63 , C12N15/67 , C12N5/10

CPC分类号： C12N9/6454 , C07K14/755

摘要： Compositions and methods are provided for endopeptidase production and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides, including proteins requiring gamma-carboxylation for biological activity. These compositions and methods utilize recombinant PACE, a mammalian endopeptidase that is specific for dibasic amino acid sites.