公开(公告)号：EP3360557A2

公开(公告)日：2018-08-15

申请号：EP17206023.8

申请日：2011-12-02

申请人： Geno LLC

发明人： FINE, David H. ,  ROSCIGNO, Robert F ,  VASQUEZ, Gregory ,  JOHNSON, Bryan ,  DENTON, Ryan

IPC分类号： A61K33/00 ,  A61P11/00 ,  A61P9/12 ,  A01N59/00

CPC分类号： A61K33/00 ,  A61P9/12 ,  A61P11/00

摘要： Portable and pure nitric oxide delivery systems can be used to treat a variety of patient conditions.

公开(公告)号：EP2501427B1

公开(公告)日：2018-03-21

申请号：EP10832320.5

申请日：2010-11-22

申请人： Geno LLC

发明人： FINE, David, H. ,  VASQUEZ, Gregory ,  JOHNSON, Bryan ,  FULLER, Jody ,  DENTON, Ryan

IPC分类号： A61M16/12 ,  A61M16/00 ,  A61M16/10 ,  A61K33/00

CPC分类号： A61M16/104 ,  A61K33/00 ,  A61M16/0057 ,  A61M16/0066 ,  A61M16/1075 ,  A61M16/12 ,  A61M2016/102 ,  A61M2202/0208 ,  A61M2202/0275 ,  A61M2205/8206

摘要： An ambulatory or stationary device for delivery of a therapeutic amount of nitric oxide to an individual's lungs.

公开(公告)号：EP2531249A1

公开(公告)日：2012-12-12

申请号：EP11737816.6

申请日：2011-01-31

申请人： Geno LLC

发明人： FINE, David, H. ,  DENTON, Ryan ,  VASQUEZ, Gregory ,  JOHNSON, Bryan

IPC分类号： A61M16/10 ,  A61M16/00

CPC分类号： A61M16/12 ,  A61M2202/0208 ,  A61M2202/0275

摘要： Methods and systems of using liquid nitrogen dioxide (N
2 O
4 ) with a ventilator can generate and deliver nitric oxide to a patient by means of a ventilator.

公开(公告)号：EP2328592B1

公开(公告)日：2017-08-02

申请号：EP09808647.3

申请日：2009-08-14

申请人： Geno LLC

发明人： FINE, David ,  JOHNSON, Bryan ,  VASQUEZ, Gregory

IPC分类号： A61K33/00 ,  A61M16/10 ,  C01B21/24

CPC分类号： A61M16/12 ,  A61M16/10 ,  A61M16/104 ,  A61M16/105 ,  A61M16/107 ,  A61M16/1075 ,  A61M16/109 ,  A61M16/16 ,  A61M2202/0275 ,  A62B7/08 ,  A62B21/00 ,  C01B21/24

摘要： Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.

摘要翻译： 本文公开了用于产生一氧化氮的各种系统和装置。 根据一个实施例，该装置包括具有入口，出口和与主体一起定位的多孔固体基质的主体。 多孔固体基质涂覆有抗氧化剂的水溶液，其中入口构造成接收气流并且通过固体基质将气流流体连通至出口以将气流中的二氧化氮转化为一氧化氮。 多孔固体基质允许设备以任何方向使用。 另外，多孔固体基质提供了一种刚性结构，适合承受震动和滥用，而不会影响设备的功能。

公开(公告)号：EP2645860A1

公开(公告)日：2013-10-09

申请号：EP11844660.8

申请日：2011-12-02

申请人： Geno LLC

发明人： FINE, David H. ,  ROSCIGNO, Robert F. ,  VASQUEZ, Gregory ,  JOHNSON, Bryan ,  DENTON, Ryan

IPC分类号： A01N59/00

CPC分类号： A61K33/00 ,  A61P9/12 ,  A61P11/00

摘要： Portable and pure nitric oxide delivery systems can be used to treat a variety of patient conditions.

公开(公告)号：EP2563435A1

公开(公告)日：2013-03-06

申请号：EP11775504.1

申请日：2011-04-26

申请人： Geno LLC

发明人： FINE, David, H. ,  VASQUEZ, Gregory ,  JOHNSON, Bryan ,  DENTON, Ryan ,  GAMERO, Lucas, G.

IPC分类号： A61M15/00 ,  A61M16/10 ,  A61M16/00 ,  A62B7/00

CPC分类号： A61M16/122 ,  A61M16/0666 ,  A61M16/10 ,  A61M16/105 ,  A61M16/1055 ,  A61M16/107 ,  A61M16/1075 ,  A61M16/12 ,  A61M2016/0027 ,  A61M2016/102 ,  A61M2202/0266 ,  A61M2202/0275 ,  A61M2202/03 ,  A61M2205/0238 ,  A61M2205/18 ,  A61M2205/3368 ,  A61M2205/3653 ,  A61M2205/7518 ,  A61M2205/8206 ,  A61M2207/10 ,  A61M2209/088 ,  C01B21/24

摘要： A system for delivering a therapeutic amount of nitric oxide can include a reservoir including a restrictor with a length of at least 0.5 inch and at most 2 inches covered by a metal sheath, a gas supply, and a delivery conduit. A delivery conduit can include at least one cartridge and a patient interface. The at least one cartridge can include a surface-active material and a reducing agent.

公开(公告)号：EP2914546A1

公开(公告)日：2015-09-09

申请号：EP13851309.8

申请日：2013-11-05

申请人： Geno LLC

发明人： FINE, David H. ,  BROMBERG, Edward ,  GAMERO, Lucas ,  DENTON, Ryan ,  VASQUEZ, Gregory ,  JOHNSON, Bryan

IPC分类号： C01B21/24 ,  A01N59/00 ,  A61K33/00

CPC分类号： A61M16/12 ,  A61K33/00 ,  A61M16/0051 ,  A61M16/024 ,  A61M16/125 ,  A61M16/16 ,  A61M2016/0039 ,  A61M2016/1025 ,  A61M2016/1035 ,  A61M2202/0208 ,  A61M2202/0275 ,  A61M2205/52 ,  A61M2230/435 ,  A61M2230/437 ,  C01B21/24

摘要： A system for the delivery of nitric oxide can include a first platform including a first source of nitric oxide, a second platform including a second source of a nitric oxide, a delivery line coupled to the first platform and the second platform, and a controller configured to operate the first platform and the second platform simultaneously. A method of delivering nitric oxide can include communicating a first gas including nitric oxide through a first platform to a delivery line, communicating a second gas including nitric oxide through a second platform to the delivery line, and delivering the first gas and the second gas to a mammal via a delivery line.

公开(公告)号：EP2914324A1

公开(公告)日：2015-09-09

申请号：EP13850709.0

申请日：2013-11-05

申请人： Geno LLC

发明人： FINE, David H. ,  BROMBERG, Edward ,  GAMERO, Lucas ,  DENTON, Ryan ,  VASQUEZ, Gregory ,  JOHNSON, Bryan

IPC分类号： A61M16/10

CPC分类号： A61K33/00 ,  A61K2300/00

摘要： A method of delivering nitric oxide can include mixing a first gas including oxygen and a second gas including a nitric oxide-releasing agent within a receptacle to form a gas mixture, where the receptacle includes an inlet, an outlet and a reducing agent, contacting the nitric oxide-releasing agent in the gas mixture with the reducing agent to generate nitric oxide, and delivering the gas mixture including nitric oxide from the receptacle to a mammal.

公开(公告)号：EP2362810A1

公开(公告)日：2011-09-07

申请号：EP09815334.9

申请日：2009-09-21

申请人： Geno LLC

发明人： FINE, David, H. ,  ROUNBEHLER, David, P. ,  VASQUEZ, Gregory ,  JOHNSON, Bryan

IPC分类号： B01D53/56

CPC分类号： B01J12/007 ,  A61K33/00 ,  A61M16/10 ,  A61M16/122 ,  A61M2016/1025 ,  A61M2202/0007 ,  A61M2202/0078 ,  A61M2202/0275 ,  A61M2205/07 ,  A61M2205/12 ,  A62B7/08 ,  C01B21/24

摘要： A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

摘要翻译： 包括在空气中具有二氧化氮的气瓶的一氧化氮输送系统将二氧化氮转化为一氧化氮，并使用涂覆有抗氧化剂水溶液如抗坏血酸的表面活性物质如硅胶。 一氧化氮递送系统可用于产生治疗气体，包括一氧化氮，用于将治疗气体递送至哺乳动物。

公开(公告)号：EP2326382A1

公开(公告)日：2011-06-01

申请号：EP09808649.9

申请日：2009-08-14

申请人： Geno LLC

发明人： FINE, David ,  VASQUEZ, Gregory ,  JOHNSON, Bryan

IPC分类号： A61M37/00

CPC分类号： A61M16/12 ,  A61M16/0051 ,  A61M16/10 ,  A61M16/16 ,  A61M16/20 ,  A61M2016/102 ,  A61M2202/0275 ,  C01B21/24

摘要： In one aspect, a system for delivering nitric oxide to a patient can include a first gas source including nitrogen dioxide mixed in air or oxygen, a second gas source supplying compressed air, a ventilator coupled to the first and second gas sources, where the ventilator can be resistant to nitrogen dioxide, and where the ventilator provides a gas flow having a proper amount of nitrogen dioxide, one or more conversion devices operably coupled to the ventilator, where the conversion devices covert nitrogen dioxide into nitric oxide, and a patient interface operably coupled to the conversion devices, where the patient interface delivers nitric oxide to the patient.