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公开(公告)号：EP4350001A2
公开(公告)日：2024-04-10
申请号：EP23213439.5
申请日：2010-11-19
申请人： Genomic Health, Inc.
IPC分类号： C12Q1/68
摘要： The present invention provides methods to determine the prognosis and appropriate treatment for patients diagnosed with cancer, based on the expression levels of one or more biomarkers. More particularly, the invention relates to the identification of genes, or sets of genes, able to distinguish breast cancer patients with a good clinical prognosis from those with a bad clinical prognosis. The invention further provides methods for providing a personalized genomics report for a cancer patient. The inventions also relates to computer systems and software for data analysis using the prognostic and statistical methods disclosed herein.
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公开(公告)号：EP3115470A1
公开(公告)日：2017-01-11
申请号：EP16181799.4
申请日：2003-03-12
申请人： Genomic Health, Inc.
IPC分类号： C12Q1/68
CPC分类号： G01N33/57484 , C12N15/1003 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415
摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived for gene expression studies.
摘要翻译： 本发明涉及测量活检肿瘤组织中的mRNA水平的敏感方法，包括归档石蜡包埋的活检材料。 本发明还涉及在乳腺癌诊断和治疗中重要的乳腺癌基因集，以及基于为基因表达研究获得的知识为乳腺癌患者分配最佳治疗选择的方法。
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公开(公告)号：EP3739060A1
公开(公告)日：2020-11-18
申请号：EP20177718.2
申请日：2010-11-19
申请人： Genomic Health, Inc.
IPC分类号： C12Q1/68
摘要： The present invention provides methods to determine the prognosis and appropriate treatment for patients diagnosed with cancer, based on the expression levels of one or more biomarkers. More particularly, the invention relates to the identification of genes, or sets of genes, able to distinguish breast cancer patients with a good clinical prognosis from those with a bad clinical prognosis. The invention further provides methods for providing a personalized genomics report for a cancer patient. The inventions also relates to computer systems and software for data analysis using the prognostic and statistical methods disclosed herein.
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公开(公告)号：EP3115470B1
公开(公告)日：2018-07-18
申请号：EP16181799.4
申请日：2003-03-12
申请人： Genomic Health, Inc.
IPC分类号： C12Q1/6886 , G01N33/574 , C12N15/10
CPC分类号： G01N33/57484 , C12N15/1003 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415
摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
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公开(公告)号：EP2504451B1
公开(公告)日：2019-06-05
申请号：EP10832289.2
申请日：2010-11-19
申请人： Genomic Health, Inc.
IPC分类号： C12Q1/68
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公开(公告)号：EP3059322A1
公开(公告)日：2016-08-24
申请号：EP15190640.1
申请日：2004-01-14
申请人： Genomic Health, Inc.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
摘要翻译： 本发明提供了在乳腺癌的诊断和/或预后中重要的基因组。
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7.发明公开METHODS OF PREDICTING CANCER RISK USING GENE EXPRESSION IN PREMALIGNANT TISSUE 审中-公开基因表达在肿瘤组织中预测癌症风险的方法
公开(公告)号：EP2417271A2
公开(公告)日：2012-02-15
申请号：EP10762395.1
申请日：2010-04-07
申请人： Genomic Health, Inc.
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The present disclosure provides methods for assessing a patient's cancer risk and/or recurrence risk, which methods comprise assaying, in a biological sample obtained from the gastrointestinal (GI) tract of the patient, an expression level of a risk gene. The present disclosure also provides methods involving a cancer risk/recurrence risk sequence, i.e. the V600E mutation of the BRAF gene, which is useful for assessing cancer risk and/or recurrence risk in a patient.
摘要翻译： 本公开提供了用于评估患者的癌症风险和/或复发风险的方法，所述方法包括在从患者的胃肠（GI）道获得的生物样品中测定风险基因的表达水平。 本公开还提供涉及癌症风险/复发风险序列的方法，即BRAF基因的V600E突变，其可用于评估患者的癌症风险和/或复发风险。
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公开(公告)号：EP4350001A3
公开(公告)日：2024-06-19
申请号：EP23213439.5
申请日：2010-11-19
申请人： Genomic Health, Inc.
IPC分类号： C12Q1/68
CPC分类号： C12Q2600/10620130101 , C12Q2600/11820130101 , C12Q2600/15820130101 , C12Q1/6886 , G16B25/00 , G16B25/10
摘要： The present invention provides methods to determine the prognosis and appropriate treatment for patients diagnosed with cancer, based on the expression levels of one or more biomarkers. More particularly, the invention relates to the identification of genes, or sets of genes, able to distinguish breast cancer patients with a good clinical prognosis from those with a bad clinical prognosis. The invention further provides methods for providing a personalized genomics report for a cancer patient. The inventions also relates to computer systems and software for data analysis using the prognostic and statistical methods disclosed herein.
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公开(公告)号：EP3059322B1
公开(公告)日：2019-04-10
申请号：EP15190640.1
申请日：2004-01-14
申请人： Genomic Health, Inc.
IPC分类号： C12Q1/6886
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公开(公告)号：EP2504451A2
公开(公告)日：2012-10-03
申请号：EP10832289.2
申请日：2010-11-19
申请人： Genomic Health, Inc.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , G06F19/20
摘要： The present invention provides methods to determine the prognosis and appropriate treatment for patients diagnosed with cancer, based on the expression levels of one or more biomarkers. More particularly, the invention relates to the identification of genes, or sets of genes, able to distinguish breast cancer patients with a good clinical prognosis from those with a bad clinical prognosis. The invention further provides methods for providing a personalized genomics report for a cancer patient. The inventions also relates to computer systems and software for data analysis using the prognostic and statistical methods disclosed herein.
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