公开(公告)号：EP2568053B1

公开(公告)日：2014-04-16

申请号：EP12195318.6

申请日：2009-05-12

申请人： Genomic Health, Inc. ,  Aventis Inc.

发明人： Shak, Steve ,  Baker, Joffre ,  Yoshizawa, Carl ,  Sparano, Joseph ,  Gray, Robert

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57415 ,  G01N2333/705 ,  G01N2333/72 ,  G01N2800/52 ,  G01N2800/60

公开(公告)号：EP2641977A1

公开(公告)日：2013-09-25

申请号：EP13172854.5

申请日：2009-05-12

申请人： Genomic Health, Inc. ,  Aventis Inc.

发明人： Shak, Steve ,  Baker, Joffre ,  Yoshizawa, Carl ,  Sparano, Joseph ,  Gray, Robert

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57415 ,  G01N2333/705 ,  G01N2333/72 ,  G01N2800/52 ,  G01N2800/60

摘要： The present disclosure provides methods and compositions to facilitate prediction of the likelihood of responsiveness of cancer patients to treatment including a taxane and/or a cyclophosphamide.

摘要翻译： 本公开提供了方法和组合物以促进预测癌症患者对包括紫杉烷和/或环磷酰胺的治疗的响应性的可能性。

公开(公告)号：EP2641978A1

公开(公告)日：2013-09-25

申请号：EP13172903.0

申请日：2009-05-12

申请人： Genomic Health, Inc. ,  Aventis Inc.

发明人： Shak, Steve ,  Baker, Joffre ,  Yoshizawa, Carl ,  Sparano, Joseph ,  Gray, Robert

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57415 ,  G01N2333/705 ,  G01N2333/72 ,  G01N2800/52 ,  G01N2800/60

摘要： The present disclosure provides methods and compositions to facilitate prediction of the likelihood of responsiveness of cancer patients to treatment including a taxane and/or a cyclophosphamide.

公开(公告)号：EP2607497A1

公开(公告)日：2013-06-26

申请号：EP13159677.7

申请日：2009-05-12

申请人： Genomic Health, Inc. ,  Aventis Inc.

发明人： Shak, Steve ,  Baker, Joffre ,  Yoshizawa, Carl ,  Gray, Robert ,  Sparano, Joseph

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57415 ,  G01N2333/705 ,  G01N2333/72 ,  G01N2800/52 ,  G01N2800/60

摘要： The present disclosure provides methods and compositions to facilitate prediction of the likelihood of responsiveness of cancer patients to treatment including a taxane and/or a cyclophosphamide.

公开(公告)号：EP2568053A1

公开(公告)日：2013-03-13

申请号：EP12195318.6

申请日：2009-05-12

申请人： Genomic Health, Inc. ,  Aventis Inc.

发明人： Shak, Steve ,  Baker, Joffre ,  Yoshizawa, Carl ,  Sparano, Joseph ,  Gray, Robert

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57415 ,  G01N2333/705 ,  G01N2333/72 ,  G01N2800/52 ,  G01N2800/60

摘要： The present disclosure provides methods and compositions to facilitate prediction of the likelihood of responsiveness of cancer patients to treatment including a taxane and/or a cyclophosphamide.

摘要翻译： 本公开提供了有助于预测癌症患者对治疗包括紫杉烷和/或环磷酰胺的治疗的可能性的方法和组合物。

公开(公告)号：EP2913405B1

公开(公告)日：2016-11-09

申请号：EP15152517.7

申请日：2011-07-25

申请人： Genomic Health, Inc.

发明人： Shak, Steve ,  Baehner, Frederick L. ,  Maddala, Tara ,  Lee, Mark ,  Pelham, Robert J. ,  Cowens, Wayne ,  Cherbavaz, Diana ,  Kiefer, Michael C. ,  Crager, Michael ,  Goddard, Audrey ,  Baker, Joffre

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178 ,  G06F19/00

摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.

公开(公告)号：EP1918386B9

公开(公告)日：2012-08-08

申请号：EP07024457.9

申请日：2003-03-12

申请人： Genomic Health, Inc.

发明人： Baker, Joffre B. ,  Cronin, Maureen T. ,  Kiefer, Michael C. ,  Shak, Steve ,  Walker, Michael G.

IPC分类号： C12Q1/68

CPC分类号： G01N33/57484 ,  C12N15/1003 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57415

摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

公开(公告)号：EP2258873A3

公开(公告)日：2011-05-04

申请号：EP10158657.6

申请日：2003-03-12

申请人： Genomic Health, Inc.

发明人： Baker, Joffre B. ,  Cronin, Maureen T. ,  Kiefer, Michael C. ,  Shak, Steve ,  Walker, Michael G.

IPC分类号： C12Q1/68

CPC分类号： G01N33/57484 ,  C12N15/1003 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57415

摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

公开(公告)号：EP2799555A1

公开(公告)日：2014-11-05

申请号：EP14163244.8

申请日：2003-03-12

申请人： Genomic Health, Inc.

发明人： Baker, Joffre ,  Cronin, Maureen T. ,  Kiefer, Michael C. ,  Shak, Steve ,  Walker, Michael G.

IPC分类号： C12Q1/68

CPC分类号： G01N33/57484 ,  C12N15/1003 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57415

摘要： Sensitive methods to measure mRNA levels in biopsied tumour tissues, including archived paraffin-embedded biopsy material, are disclosed. Breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patients based upon knowledge derived from gene expression studies are also disclosed.

摘要翻译： 公开了用于测量活检肿瘤组织中的mRNA水平的敏感方法，包括封存石蜡包埋的活组织检查材料。 乳腺癌基因在乳腺癌的诊断和治疗中是重要的，并且还公开了基于从基因表达研究得到的知识为乳腺癌患者分配最佳治疗选择的方法。

公开(公告)号：EP2641977B1

公开(公告)日：2014-09-03

申请号：EP13172854.5

申请日：2009-05-12

申请人： Genomic Health, Inc. ,  Aventisub II Inc.

发明人： Shak, Steve ,  Baker, Joffre ,  Yoshizawa, Carl ,  Sparano, Joseph ,  Gray, Robert

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57415 ,  G01N2333/705 ,  G01N2333/72 ,  G01N2800/52 ,  G01N2800/60