公开(公告)号：EP2504332B1

公开(公告)日：2014-06-04

申请号：EP10785289.9

申请日：2010-11-24

申请人： Genzyme Corporation

发明人： LIU, Hanlan ,  WILLIS, Chris ,  BHARDWAJ, Renu ,  COPELAND, Diane, P. ,  HARIANAWALA, Abizer ,  SKELL, Jeffrey ,  MARSHALL, John ,  KOCHLING, Jianmei ,  PALACE, Gerard ,  PETERSCHMITT, Judith ,  SIEGEL, Craig ,  CHENG, Seng

IPC分类号： C07D405/06 ,  A61K31/4025 ,  A61P35/00

CPC分类号： A61K31/4025 ,  A61K45/06 ,  C07D319/16 ,  C07D405/06

公开(公告)号：EP2504332A1

公开(公告)日：2012-10-03

申请号：EP10785289.9

申请日：2010-11-24

申请人： Genzyme Corporation

发明人： LIU, Hanlan ,  WILLIS, Chris ,  BHARDWAJ, Renu ,  COPELAND, Diane, P. ,  HARIANAWALA, Abizer ,  SKELL, Jeffrey ,  MARSHALL, John ,  KOCHLING, Jianmei ,  PALACE, Gerard ,  PETERSCHMITT, Judith ,  SIEGEL, Craig ,  CHENG, Seng

IPC分类号： C07D405/06 ,  A61K31/4025 ,  A61P35/00

CPC分类号： A61K31/4025 ,  A61K45/06 ,  C07D319/16 ,  C07D405/06

摘要： The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.

公开(公告)号：EP0733070A1

公开(公告)日：1996-09-25

申请号：EP95905871.0

申请日：1994-12-08

申请人： GENZYME CORPORATION

发明人： BARSOMIAN, Gary ,  COPELAND, Diane, P. ,  HILLHOUSE, Dana ,  JOHNSON, Tracy

IPC分类号： G01N33 ,  C07K16 ,  C12N1 ,  C12N15 ,  C12P21 ,  C12R1

CPC分类号： C07K16/00 ,  C07K2319/00 ,  C07K2319/735 ,  C12N15/62

摘要： The present invention relates to a method for generating an antibody which is specific for an immunorecessive epitope, and nucleic acid encoding the antibody. The subject method generally comprises the steps of generating a variegated display library of antibody variable regions, and selecting from the library those antibody variable regions which have a desired binding specificity for the immunorecessive epitope. The antibody variable regions used to generate the display library are cloned from an immunotolerance-derived antibody repertoire.

摘要翻译： 本发明涉及用于产生对免疫过敏性表位特异的抗体的方法和编码该抗体的核酸。 主题方法通常包括产生抗体可变区的多样化展示文库并从文库中选择那些对免疫过
敏表位具有所需结合特异性的抗体可变区的步骤。 用于产生展示文库的抗体可变区由免疫耐受衍生抗体库克隆。