公开(公告)号：EP3149212B1

公开(公告)日：2020-08-26

申请号：EP15799039.1

申请日：2015-06-01

申请人： Georgia State University Research Foundation, Inc.

发明人： IYER, Suri Saranathan ,  DHAWANE, Abasaheb ,  HE, Yun ,  ZHANG, Xiaohu ,  DINH, Hieu ,  VASIREDDI, Mugdha ,  SWEENEY, Joyce

IPC分类号： C07H3/04 ,  C07H15/04 ,  C07H15/18 ,  C07H17/075 ,  C12Q1/34 ,  G01N27/327

公开(公告)号：EP3149212A1

公开(公告)日：2017-04-05

申请号：EP15799039.1

申请日：2015-06-01

申请人： Georgia State University Research Foundation, Inc.

发明人： IYER, Suri Saranathan ,  DHAWANE, Abasaheb ,  HE, Yun ,  ZHANG, Xiaohu ,  DINH, Hieu ,  VASIREDDI, Mugdha ,  SWEENEY, Joyce

IPC分类号： C12Q1/70 ,  G01N27/327

摘要： Disclosed are compositions and methods for the electrochemical detection of enzymes, such as enzymes that are indicative of disease, disorders, or pathogens, such as viruses, bacteria, and fungi, or other disorders. These methods can be used in point-of-care diagnostic assays for the detection of disease, disorder, or pathogen (e.g., to identify the strain of pathogen infecting a patient in a healthcare setting). The electrochemical methods described herein can also be used to assess the susceptibility of a pathogen to an antipathogen drug. Also provided are probes suitable for use in conjunction with the methods described herein.

摘要翻译： 公开了电化学检测酶的组合物和方法，例如指示疾病，病症或病原体如病毒，细菌和真菌或其它病症的酶。 这些方法可以用于检测疾病，病症或病原体的点护理诊断测定（例如，鉴定在医疗保健环境中感染患者的病原体的菌株）。 本文所述的电化学方法也可用于评估病原体对抗病原体药物的易感性。 还提供了适合与本文所述方法结合使用的探针。