公开(公告)号：EP1176977A2

公开(公告)日：2002-02-06

申请号：EP00926611.5

申请日：2000-05-05

申请人： Gestilab Inc.

发明人： PAQUIN, Joanne ,  MATEESCU, Mircea-Alexandru ,  DE GRANDPR , ric

IPC分类号： A61K38/57 ,  A61K38/43

CPC分类号： C12Y116/03001 ,  A61K38/44 ,  A61K2300/00

摘要： A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a therapeutically effective amount of ceruloplasmin or a functional derivative thereof. The neuroprotective composition is characterized in that it protects neuronal cells from reactive oxygen species such as •O2- and •OH. In a preferred embodiment, the neuroprotective composition further comprises an antioxidant consisting of catalase or of an amphiphilic physiological antioxidative solution comprising a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.

公开(公告)号：EP1181049A1

公开(公告)日：2002-02-27

申请号：EP00926610.7

申请日：2000-05-05

申请人： Gestilab Inc.

发明人： MATEESCU, Mircea-Alexandru ,  PAQUIN, Joanne ,  LANGLOIS, Denis ,  AOUFFEN, Mhamed

IPC分类号： A61K38/57 ,  A61K31/19 ,  A61K31/20 ,  A61K45/06 ,  A61P39/06

CPC分类号： A61K38/44 ,  C12Y116/03001 ,  A61K31/355 ,  A61K31/20 ,  A61K31/19 ,  A61K31/07 ,  A61K31/015 ,  A61K2300/00

摘要： A cardioprotective composition for protecting heart against oxidative stress and methods for using and preparing the same. More particularly, the cardioprotective composition of the invention comprises a mixture of pyruvate, antioxidant, fatty acids and ceruloplasmin. The cardioprotective composition could be used for the treatment of heart attack/failure, the treatment of ischemic cardiopathy, the conservation of heart before and during transplantation, and the treatment heart oxidative stress related conditions.

公开(公告)号：EP1176955A1

公开(公告)日：2002-02-06

申请号：EP00926612.3

申请日：2000-05-05

申请人： Gestilab Inc.

发明人： MATEESCU, Mircea-Alexandru ,  PAQUIN, Joanne ,  LANGLOIS, Denis ,  WANG, Xintao ,  AOUFFEN, Mhamed

IPC分类号： A61K31/19 ,  A61K31/23 ,  A61K31/355 ,  A61P9/00

CPC分类号： A61K31/19 ,  A61K31/23 ,  A61K31/355 ,  A61K31/07 ,  A61K31/015 ,  A61K2300/00

摘要： A cardioprotective composition for protecting heart against oxidative stress and methods for using and preparing the same. More particularly, the cardioprotective composition of the invention comprises a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The cardioprotective composition could be used for the treatment of heart attack/failure, the treatment of ischemic cardiopathy, the conservation of heart before and during transplantation, and the treatment of heart oxidative stress related conditions.

公开(公告)号：EP1176954A1

公开(公告)日：2002-02-06

申请号：EP00926605.7

申请日：2000-05-05

申请人： Gestilab Inc.

发明人： PAQUIN, Joanne ,  MATEESCU, Mircea-Alexandru ,  DE GRANDPRE, Eric

IPC分类号： A61K31/19 ,  A61K31/23 ,  A61K31/355 ,  A61P25/00 ,  A61P9/00

CPC分类号： A61K31/19 ,  A61K31/23 ,  A61K31/355 ,  A61K31/07 ,  A61K31/015 ,  A61K2300/00

摘要： A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.