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1.发明公开MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS 审中-公开改性多羟基化合物ZER HOSTELLUNG VON ZYTOPLASMA- UND ZYTOSKELETT-PROTEINEN
公开(公告)号：EP2847329A4
公开(公告)日：2016-08-10
申请号：EP13772653
申请日：2013-03-09
发明人： BANCEL STEPHANE , CHAKRABORTY TIRTHA , DE FOUGEROLLES ANTONIN , ELBASHIR SAYDA M , JOHN MATTHIAS , ROY ATANU , WHORISKEY SUSAN , WOOD KRISTY M , HATALA PAUL , SCHRUM JASON P , EJEBE KENECHI , ELLSWORTH JEFF LYNN , GUILD JUSTIN
IPC分类号： C12N15/10
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及用于制备，制造和治疗性使用多核苷酸，初级转录物和mmRNA分子的组合物和方法。
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公开(公告)号：EP2833923A4
公开(公告)日：2016-02-24
申请号：EP13772137
申请日：2013-03-09
发明人： BANCEL STEPHANE , CHAKRABORTY TIRTHA , DE FOUGEROLLES ANTONIN , ELBASHIR SAYDA M , JOHN MATTHIAS , ROY ATANU , WHORISKEY SUSAN , WOOD KRISTY M , HATALA PAUL , SCHRUM JASON P , EJEBE KENECHI , ELLSWORTH JEFF LYNN , GUILD JUSTIN
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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3.发明公开MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE 审中-公开修饰的多核苷酸为蛋白质相关与疾病在人类生产
公开(公告)号：EP2849799A2
公开(公告)日：2015-03-25
申请号：EP13722158.6
申请日：2013-03-09
发明人： BANCEL, Stephane , CHAKRABORTY, Tirtha , DE FOUGEROLLES, Antonin , ELBASHIR, Sayda, M. , JOHN, Matthias , ROY, Atanu , WHORISKEY, Susan , WOOD, Kristy, M. , HATALA, Paul , SCHRUM, Jason, P. , EJEBE, Kenechi , ELLSWORTH, Jeff, Lynn , GUILD, Justin
IPC分类号： A61K48/00 , C07K14/47 , C12N15/85 , A61K31/7115 , C12N9/88
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及组合物和方法用于制备，制造和治疗用途的多核苷酸，初级转录物和mmRNA的分子。
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4.发明公开MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS 审中-公开修饰的多核苷酸准备和细胞质细胞骨架蛋白
公开(公告)号：EP2847329A1
公开(公告)日：2015-03-18
申请号：EP13772653.5
申请日：2013-03-09
发明人： BANCEL, Stephane , CHAKRABORTY, Tirtha , DE FOUGEROLLES, Antonin , ELBASHIR, Sayda, M. , JOHN, Matthias , ROY, Atanu , WHORISKEY, Susan , WOOD, Kristy M. , HATALA, Paul , SCHRUM, Jason, P. , EJEBE, Kenechi , ELLSWORTH, Jeff, Lynn , GUILD, Justin
IPC分类号： C12N15/10
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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5.发明授权USE OF MELANOMA BIOMARKERS IN MEDICAL AND DIAGNOSTIC FIELD AND METHOD FOR THE IDENTIFICATION THEREOF 有权医疗和诊断目的MELANOMBIOMARKERN FOR和方法，其医疗诊断中的应用
公开(公告)号：EP2591362B1
公开(公告)日：2015-02-25
申请号：EP11754530.1
申请日：2011-07-08
发明人： FACCHIANO, Francesco
IPC分类号： G01N33/574
CPC分类号： G01N33/5743 , A61K38/1709 , A61K38/38 , A61K38/44 , A61K38/57 , C12Y116/03001 , G01N2800/042
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6.发明公开MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF ONCOLOGY-RELATED PROTEINS AND PEPTIDES 审中-公开修饰的多核苷酸用于制造在肿瘤学有用的蛋白质和肽
公开(公告)号：EP2833892A4
公开(公告)日：2016-07-20
申请号：EP13772721
申请日：2013-03-09
发明人： BANCEL STEPHANE , CHAKRABORTY TIRTHA , DE FOUGEROLLES ANTONIN , ELBASHIR SAYDA M , JOHN MATTHIAS , ROY ATANU , WHORISKEY SUSAN , WOOD KRISTY M , HATALA PAUL , SCHRUM JASON P , EJEBE KENECHI , ELLSWORTH JEFF LYNN , GUILD JUSTIN
IPC分类号： A61K31/7105
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及组合物和方法用于制备，制造和治疗用途的多核苷酸，初级转录物和mmRNA的分子。
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公开(公告)号：EP3012267A1
公开(公告)日：2016-04-27
申请号：EP15181464.7
申请日：2011-07-27
申请人： Testi, Roberto
发明人： Testi, Roberto
IPC分类号： C07K14/47
CPC分类号： C12N9/0091 , A61K38/44 , C07K14/47 , C12Y116/03001
摘要： Described herein are compositions and methods for treating Friedreich's Ataxia (FRDA). In some aspects, mutant forms of frataxin which are resistant to ubiquitination are provided. In some aspects, pharmaceutical compositions comprising mutant frataxin are provided. In further aspects, methods of using mutant frataxin are provided.
摘要翻译： 本文描述了用于治疗弗里德赖希共济失调（FRDA）的组合物和方法。 在一些方面，提供了抗泛素化的frataxin的突变体形式。 在一些方面，提供了包含突变frataxin的药物组合物。 在另外的方面，提供了使用突变体frataxin的方法。
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8.发明公开MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS 审中-公开改良多元醇ZER HERSTELLUNG VON KERNPROTEINEN
公开(公告)号：EP2834358A2
公开(公告)日：2015-02-11
申请号：EP13772943.0
申请日：2013-03-09
发明人： BANCEL, Stephane , CHAKRABORTY, Tirtha , DE FOUGEROLLES, Antonin , ELBASHIR, Sayda M. , JOHN, Matthias , ROY, Atanu , WHORISKEY, Susan , WOOD, Kristy M. , HATALA, Paul , SCHRUM, Jason P. , EJEBE, Kenechi , ELLSWORTH, Jeff Lynn , GUILD, Justin
IPC分类号： C12N15/11
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及用于制备，制造和治疗性使用多核苷酸，初级转录物和mmRNA分子的组合物和方法。
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9.发明公开MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF MEMBRANE PROTEINS 审中-公开多元醇多元醇ZUR HERSTELLUNG VON MEMBRANPROTEINEN
公开(公告)号：EP2834260A1
公开(公告)日：2015-02-11
申请号：EP13773019.8
申请日：2013-03-09
发明人： BANCEL, Stephane , CHAKRABORTY, Tirtha , DE FOUGEROLLES, Antonin , ELBASHIR, Sayda M. , JOHN, Matthias , ROY, Atanu , WHORISKEY, Susan , WOOD, Kristy M. , HATALA, Paul , SCHRUM, Jason P. , EJEBE, Kenechi , ELLSWORTH, Jeff Lynn , GUILD, Justin
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及用于制备，制造和治疗性使用多核苷酸，初级转录物和mmRNA分子的组合物和方法。
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10.发明公开A MULTICOPPER OXIDASE MUTANT, A GENE CODING THEREOF, AND A BIOFUEL-CELL USING THE SAME 审中-公开MULTIKUPFEROXIDASEMUTANT，基因编码和生物燃料电池SO
公开(公告)号：EP2764567A1
公开(公告)日：2014-08-13
申请号：EP12778812.3
申请日：2012-10-05
发明人： KUSUMEGI, Takahiro , TERADA, Kumi
CPC分类号： C12N9/001 , C12N9/0091 , C12Y116/03001 , H01M8/16 , Y02E60/527
摘要： The present invention provides a multicopper oxidase mutant having improved resistance to imidazole compounds. A multicopper oxidase mutant, which comprises an amino acid sequence derived from the amino acid sequence shown in SEQ ID NO: 2 by substitution of either or both an amino acid residue corresponding to methionine at position 157 and an amino acid residue corresponding to proline at position 414 with a different amino acid and has activity of catalyzing a reaction generating water molecules via four-electron reduction of oxygen molecules using ABTS (2,2'-azinobis(3-ethylbenzoline-6-sulfonate)) as a substrate is provided.
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