公开(公告)号：EP2254878A1

公开(公告)日：2010-12-01

申请号：EP08713963.0

申请日：2008-01-24

申请人： Gilead Palo Alto, Inc. ,  The Endowment for Research in Human Biology, Inc.

发明人： BILOKIN, Yaroslav ,  ELZEIN, Elfatih ,  ZABLOCKI, Jeff ,  ORGAN, Michael ,  PERRY, Thao ,  KOBAYASHI, Tetsuya ,  ABELMAN, Matthew ,  KALLA, Rao ,  FAN, Peidong ,  DIAMOND, Ivan ,  JIANG, Robert ,  AROLFO, Maria, Pia ,  LI, Xiaofen ,  YAO, Lina ,  JIANG, Zhan ,  KEUNG, Wing Ming ,  TAO, Guoxin

IPC分类号： C07D311/36 ,  C07D405/04 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  A61K31/353 ,  A61P25/32

CPC分类号： C07D311/36 ,  C07D405/04 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.