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公开(公告)号：EP3192870A1
公开(公告)日：2017-07-19
申请号：EP17153990.1
申请日：2012-04-10
发明人： Zender, Lars , Wüstefeld, Torsten
IPC分类号： C12N15/113 , C12N5/071 , C12M3/00 , A61M1/02 , A61K31/00
CPC分类号： A61K35/407 , A61K31/00 , A61K31/352 , A61K31/353 , A61K31/416 , A61K31/4709 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K31/713 , A61M1/36 , C07C237/42 , C07D213/75 , C07D231/54 , C07D231/56 , C07D311/30 , C07D311/36 , C07D401/12 , C07D407/12 , C07D473/38 , C07D487/04 , C12N5/067 , C12N15/1137 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12Y207/11024
摘要： The present invention relates to cultivated hepatocyte for blood purification, wherein the hepatocyte contains a compound which is an inhibitor of the activity of MKK4, MKK4 being encoded by SEQ ID NO: 1204.
摘要翻译： 本发明涉及用于血液净化的培养肝细胞，其中肝细胞含有作为MKK4活性抑制剂的化合物，MKK4由SEQ ID NO：1204编码。
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公开(公告)号：EP2496567B1
公开(公告)日：2017-07-12
申请号：EP10803619.5
申请日：2010-11-03
发明人： MUTHUPPALANIAPPAN, Meyyappan , VISWANADHA, Srikant , BABU, Govindarajulu , VAKKALANKA, Swaroop Kumar V.S.
IPC分类号： C07D311/34 , C07D405/06 , C07D487/04 , A61K31/519 , A61K31/52 , A61P35/00 , A61P37/06
CPC分类号： C07D311/36 , A61K31/352 , A61K31/4178 , A61K31/4184 , A61K31/437 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/5377 , A61K45/06 , C07D405/06 , C07D413/10 , C07D413/14 , C07D471/04 , C07D473/08 , C07D473/34 , C07D473/38 , C07D473/40 , C07D487/04 , Y02A50/422
摘要： The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.
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公开(公告)号：EP2560652A4
公开(公告)日：2013-08-14
申请号：EP11772680
申请日：2011-04-20
申请人： KINETA INC
发明人： IADONATO SHAWN P , BEDARD KRISTIN
IPC分类号： A61K31/4725 , A61K31/353 , A61K31/37 , A61K31/4433 , A61K31/47 , A61P31/12 , C07D215/00 , C07D311/36 , C07D401/04 , C07D405/04
CPC分类号： A61K31/353 , A61K31/4433 , C07D311/36 , C07D405/04 , C12N2770/24211 , C12N2770/32211
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公开(公告)号：EP2533637A4
公开(公告)日：2013-07-17
申请号：EP10845917
申请日：2010-02-12
发明人： SUN XICHENG , QIU JIAN , WASLEY JAN
IPC分类号： C07D311/36 , A61K31/352 , A61P9/00 , A61P9/12 , A61P11/00 , A61P11/06
CPC分类号： A61K31/352 , A61K31/381 , C07D311/34 , C07D311/36 , C07D409/04
摘要： The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
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公开(公告)号：EP2533637A1
公开(公告)日：2012-12-19
申请号：EP10845917.3
申请日：2010-02-12
发明人： SUN, Xicheng , QIU, Jian , WASLEY, Jan
CPC分类号： A61K31/352 , A61K31/381 , C07D311/34 , C07D311/36 , C07D409/04
摘要： The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
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6.发明公开Medicament for liver regeneration and for treatment of liver failure 审中-公开Medikament zur Leberregeneration und zur Behandlung von Leberversagen
公开(公告)号：EP2508607A1
公开(公告)日：2012-10-10
申请号：EP11167373.7
申请日：2011-05-24
发明人： Zender, Lars , Wüstefeld, Torsten
IPC分类号： C12N15/113 , A61K31/00
CPC分类号： A61K35/407 , A61K31/00 , A61K31/352 , A61K31/353 , A61K31/416 , A61K31/4709 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K31/713 , A61M1/36 , C07C237/42 , C07D213/75 , C07D231/54 , C07D231/56 , C07D311/30 , C07D311/36 , C07D401/12 , C07D407/12 , C07D473/38 , C07D487/04 , C12N5/067 , C12N15/1137 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12Y207/11024
摘要： The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient.
摘要翻译： 本发明涉及抑制MKK4活性的化合物作为治疗患有肝功能受损的患者的药物的用途，涉及使用化合物作为治疗肝衰竭的药物，包括急性 /暴发性或慢性肝衰竭和/或用于增加患者中肝组织的再生。
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公开(公告)号：EP2237785A4
公开(公告)日：2011-11-23
申请号：EP08870156
申请日：2008-12-29
申请人： UNIV EMORY
发明人： ARBISER JACK L
IPC分类号： A61K31/55 , A61K31/136 , A61K31/14 , A61K31/353 , A61K31/40 , A61K31/404 , A61K31/422 , A61K31/428 , A61K31/4706 , A61K31/4709 , A61P27/00 , A61P27/06 , A61P27/12 , A61P33/02 , A61P33/06 , A61P35/00
CPC分类号： A61K31/55 , A61K9/127 , A61K31/136 , A61K31/14 , A61K31/353 , A61K31/404 , A61K31/422 , A61K31/428 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K31/54 , A61K31/553 , A61K31/662 , C07D215/26 , C07D215/46 , C07D223/26 , C07D223/28 , C07D263/32 , C07D275/06 , C07D279/28 , C07D311/36 , C07F9/4056 , C07F9/4059
摘要： Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, inflammatory, degenerative and vascular diseases, including various ocular diseases, and parasitic infections. Representative triphenyl methane analogs include triphenyl methane analogues of various dyes, hormones, sugars, peptides, oligonucleotides, amino acids, nucleotides, nucleosides, and polyols. The compounds are believed to function by inhibiting tNOX expression, the effects of ROS, and/or the production of HIF2. Thus, the compounds are novel therapeutic agents for a variety of cancers and other diseases.
摘要翻译： 公开了化合物，包括该化合物的药物组合物，及其制备方法和用途。 化合物是三苯甲烷类似物。 化合物和组合物可用于治疗和/或预防多种癌症，包括耐药性癌症，炎症，退行性和血管疾病，包括各种眼部疾病和寄生虫感染。 代表性的三苯甲烷类似物包括各种染料，激素，糖，肽，寡核苷酸，氨基酸，核苷酸，核苷和多元醇的三苯基甲烷类似物。 据信这些化合物通过抑制tNOX表达，ROS的作用和/或HIF2的产生起作用。 因此，这些化合物是用于各种癌症和其它疾病的新型治疗剂。
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公开(公告)号：EP2157086A1
公开(公告)日：2010-02-24
申请号：EP08764120.5
申请日：2008-06-13
发明人： ISOBE, Yosuke , KAMO, Shuichi , SATO, Toshiro , YOSHIDA, Hiroyuki
IPC分类号： C07D309/32 , B01J3/00 , C07D311/36 , C07D311/40 , C07J63/00
CPC分类号： C07J63/00 , C07D309/32 , C07D311/36 , C07D311/40
摘要： It is intended to provide a method for producing aglycone from a glycoside efficiently at low cost without using an acid catalyst or an organic solvent. The method for producing aglycone, characterized by bringing a glycoside into contact with high temperature high pressure water. The temperature of the high temperature high pressure water is generally from 100 to 374°C, preferably from 140 to 320°C, more preferably from 200 to 300°C. The pressure of the high temperature high pressure water may be not lower than the saturated water vapor pressure at the temperature, i.e., a pressure at which the liquid state is maintained.
摘要翻译： 目的在于提供不使用酸催化剂或有机溶剂，以低成本有效地从糖苷制造糖苷配基的方法。 该糖苷配基的制造方法，其特征在于，使糖苷与高温高压水接触。 高温高压水的温度通常为100至374℃，优选140至320℃，更优选200至300℃。 高温高压水的压力可以不低于该温度下的饱和水蒸汽压力，即保持液体状态的压力。
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9.发明公开CHROMEN-4-ONE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF 审中-公开苯并吡喃-4- ON-抑制剂Bcl-2家族和使用的抗细胞凋亡成员
公开(公告)号：EP1856083A4
公开(公告)日：2009-05-27
申请号：EP06748344
申请日：2006-03-13
申请人： UNIV MICHIGAN
发明人： WANG SHAOMENG , DING KE , TANG GUOZHI , WANG RENXIAO , YANG CHAO-YIE , NIKOLOVSKA-COLESKA ZANETA
IPC分类号： C07D311/22 , A61K31/335 , A61P35/00 , C07D311/36 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04
CPC分类号： C07D311/22 , C07D311/36 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04 , C07D495/04
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公开(公告)号：EP1670485A4
公开(公告)日：2009-03-11
申请号：EP04789726
申请日：2004-10-08
申请人： RESVERLOGIX CORP
发明人： WONG NORMAN , TUCKER JOE , MCCAFFREY DAVID ROBERT
IPC分类号： A61K31/66 , A61K31/015 , A61K31/04 , A61K31/05 , A61K31/122 , A61K31/21 , A61K31/352 , A61K31/353 , A61K31/397 , A61K31/40 , A61K31/404 , A61K31/44 , A61K31/505 , A61K35/00 , A61P39/06 , C07C15/18 , C07C39/15 , C07C203/10 , C07C311/21 , C07C317/22 , C07C323/18 , C07D205/08 , C07D207/40 , C07D207/416 , C07D209/12 , C07D213/48 , C07D239/42 , C07D309/30 , C07D311/30 , C07D311/32 , C07D311/36 , C07D311/38 , C07D407/14 , C12Q1/68
CPC分类号： C07H7/02 , A61K31/05 , A61K31/135 , A61K31/21 , A61K31/353 , A61K31/655 , A61K31/7048 , C07C203/10 , C07C311/21 , C07C317/22 , C07C323/18 , C07C2602/10 , C07D205/08 , C07D207/416 , C07D209/12 , C07D213/48 , C07D239/42 , C07D309/30 , C07D311/30 , C07D311/32 , C07D311/36 , C07D311/38 , C07D407/14 , C07H7/033
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