公开(公告)号：EP4036099A1

公开(公告)日：2022-08-03

申请号：EP21209687.9

申请日：2015-10-29

申请人： Gilead Sciences, Inc.

发明人： AXT, Steven Donald ,  BADALOV, Pavel Robertovich ,  BRAK, Katrien ,  CAMPAGNA, Silvio ,  CHTCHEMELININE, Andrei ,  DOERFFLER, Edward ,  FRICK, Morin Mae ,  GAO, Detian ,  HEUMANN, Lars V. ,  HOANG, Brittanie ,  LEW, Willard ,  MILBURN, Robert Ronald ,  NEVILLE, Sean Timothy ,  ROSS, Bruce ,  RUEDEN, Erick ,  SCOTT, Robert William ,  SIEGEL, Dustin ,  STEVENS, Andrew C. ,  TADEUS, Clarissa ,  VIERA, Tiago ,  WALTMAN, Andrew W. ,  WANG, Xianghong ,  WHITCOMB, Mark Charles ,  WOLFE, Lydia ,  YU, Chia-Yun

IPC分类号： C07H1/02 ,  C07H1/00 ,  C07H11/00 ,  C07H15/18 ,  A61P31/12 ,  A61P31/00 ,  A61P43/00 ,  A61K31/675 ,  A61K31/685 ,  A61K31/706 ,  A61K31/7056 ,  C07D487/04 ,  C07D519/00 ,  A61K31/53 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  A61P31/14

摘要： Provided are methods of preparing compounds and pharmaceutical compositions for treating Filoviridae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
A method preparing a compound of Formula (XI-a 2 ) is disclosed: