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公开(公告)号：EP3087085B1
公开(公告)日：2019-02-20
申请号：EP14822040.3
申请日：2014-12-18
发明人： CAGULADA, Amy , CHAN, Johann , CHAN, Lina , COLBY, Denise A. , KARKI, Kapil Kumar , KATO, Darryl , KEATON, Katie Ann , KONDAPALLY, Sudha , LEVINS, Chris , LITTKE, Adam , MARTINEZ, Ruben , PCION, Dominika , REYNOLDS, Troy , ROSS, Bruce , SANGI, Michael , SCHRIER, Adam J. , SENG, Pamela , SIEGEL, Dustin , SHAPIRO, Nathan , TANG, Donald , TAYLOR, James G. , TRIPP, Jonathan , YU, Lawrence , WALTMAN, Andrew W.
IPC分类号： C07K5/12
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公开(公告)号：EP4036099A1
公开(公告)日：2022-08-03
申请号：EP21209687.9
申请日：2015-10-29
发明人： AXT, Steven Donald , BADALOV, Pavel Robertovich , BRAK, Katrien , CAMPAGNA, Silvio , CHTCHEMELININE, Andrei , DOERFFLER, Edward , FRICK, Morin Mae , GAO, Detian , HEUMANN, Lars V. , HOANG, Brittanie , LEW, Willard , MILBURN, Robert Ronald , NEVILLE, Sean Timothy , ROSS, Bruce , RUEDEN, Erick , SCOTT, Robert William , SIEGEL, Dustin , STEVENS, Andrew C. , TADEUS, Clarissa , VIERA, Tiago , WALTMAN, Andrew W. , WANG, Xianghong , WHITCOMB, Mark Charles , WOLFE, Lydia , YU, Chia-Yun
IPC分类号： C07H1/02 , C07H1/00 , C07H11/00 , C07H15/18 , A61P31/12 , A61P31/00 , A61P43/00 , A61K31/675 , A61K31/685 , A61K31/706 , A61K31/7056 , C07D487/04 , C07D519/00 , A61K31/53 , A61K31/6615 , A61K31/665 , A61K31/683 , A61P31/14
摘要： Provided are methods of preparing compounds and pharmaceutical compositions for treating Filoviridae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
A method preparing a compound of Formula (XI-a 2 ) is disclosed:-
公开(公告)号：EP3212175A1
公开(公告)日：2017-09-06
申请号：EP15801008.2
申请日：2015-10-29
发明人： AXT, Steven, Donald , BADALOV, Pavel, Robertovich , BRAK, Katrien , CAMPAGNA, Silvio , CHTCHEMELININE, Andrei , DOERFFLER, Edward , FRICK, Morin, Mae , GAO, Detian , HEUMANN, Lars, V. , HOANG, Brittanie , LEW, Willard , MILBURN, Robert, Ronald , NEVILLE, Sean, Timothy , ROSS, Bruce , RUEDEN, Erick , SCOTT, Robert William , SIEGEL, Dustin , STEVENS, Andrew, C. , TADEUS, Clarissa , VIEIRA, Tiago , WALTMAN, Andrew W. , WANG, Xianghong , WHITCOMB, Mark Charles , WOLFE, Lydia , YU, Chia-Yun
IPC分类号： A61K31/00 , A61K31/53 , A61K31/675 , A61K31/685 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , C07D487/04 , C07D519/00
CPC分类号： A61K31/685 , A61K31/00 , A61K31/53 , A61K31/6615 , A61K31/665 , A61K31/675 , A61K31/683 , A61K45/06 , C07D487/04 , C07D519/00 , C07F9/2429 , C07F9/65616 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K2300/00
摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
摘要翻译： 本发明提供了用于治疗丝状病毒科病毒感染的化合物，方法和药物组合物，其通过施用式IV的核糖苷，核苷磷酸酯及其前药：所提供的化合物，组合物和方法对于治疗马尔堡病毒，埃博拉病毒和库埃瓦 病毒感染。
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公开(公告)号：EP3087085A1
公开(公告)日：2016-11-02
申请号：EP14822040.3
申请日：2014-12-18
发明人： CAGULADA, Amy , CHAN, Johann , CHAN, Lina , COLBY, Denise A. , KARKI, Kapil Kumar , KATO, Darryl , KEATON, Katie Ann , KONDAPALLY, Sudha , LEVINS, Chris , LITTKE, Adam , MARTINEZ, Ruben , PCION, Dominika , REYNOLDS, Troy , ROSS, Bruce , SANGI, Michael , SCHRIER, Adam J. , SENG, Pamela , SIEGEL, Dustin , SHAPIRO, Nathan , TANG, Donald , TAYLOR, James G. , TRIPP, Jonathan , YU, Lawrence , WALTMAN, Andrew W.
IPC分类号： C07K5/12
CPC分类号： C07D498/18 , C07C51/09 , C07C205/57 , C07C209/00 , C07C227/02 , C07C233/09 , C07C251/12 , C07C255/61 , C07C271/34 , C07C2601/02 , C07D241/44 , C07D403/12 , C07D453/02 , C07D498/16 , C07K5/0808
摘要： The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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