公开(公告)号：EP1324990B1

公开(公告)日：2014-10-29

申请号：EP01970023.6

申请日：2001-09-28

申请人： Glaxo Group Limited

发明人： ANCLIFF, Rachael Anne ,  COOK, Caroline Mary ,  ELDRED, Colin David ,  GORE, Paul Martin ,  HARRISON, Lee Andrew ,  HODGSON, Simon Teanby ,  JUDD, Duncan Bruce ,  KEELING, Suzanne Elaine ,  LEWELL, Xiao Qing ,  ROBERTSON, Graeme Michael ,  SWANSON, Stephen

IPC分类号： C07D265/30 ,  C07D413/12 ,  C07D417/12 ,  C07D413/06 ,  C07D417/14 ,  C07D413/14 ,  A61K31/5375 ,  A61P29/00

CPC分类号： C07D265/30 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

公开(公告)号：EP1324990A1

公开(公告)日：2003-07-09

申请号：EP01970023.6

申请日：2001-09-28

申请人： GLAXO GROUP LIMITED

发明人： ANCLIFF, Rachael Anne ,  COOK, Caroline Mary ,  ELDRED, Colin David ,  GORE, Paul Martin ,  HARRISON, Lee Andrew ,  HODGSON, Simon Teanby ,  JUDD, Duncan Bruce ,  KEELING, Suzanne Elaine ,  LEWELL, Xiao Qing ,  ROBERTSON, Graeme Michael ,  SWANSON, Stephen

IPC分类号： C07D265/30 ,  C07D413/12 ,  C07D417/12 ,  C07D413/06 ,  C07D417/14 ,  C07D413/14 ,  A61K31/5375 ,  A61P29/00

CPC分类号： C07D265/30 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： Compounds of formula (I) wherein: R1 represents C¿1-16? alkyl, C2-6alkenyl, C2-6alkynyl, C2-6alkynyl-Y?1¿-, aryl-Y1-, heteroaryl-Y1-, aryl-(O)¿t?-aryl-Y?1¿-, aryl-(O)¿t?-heteroaryl-Y?1¿-, heteroaryl-(O)¿t?-aryl-Y?1¿-, heteroaryl-(O)¿t?-heteroaryl-Y?1¿-, C¿2-6? alkenyl-Y?1¿-, aryl-O-Y1-, heteroaryl-O-Y1-, C¿1-16? alkyl-SO2-Y?1-,M-Y1-,J2-Y1¿-, -CN or C¿3-8? cycloalkyl-Y?1¿-or C¿3-8? cycloalkenyl-Y?1¿-, which cycloalkyl or cycloalkenyl may be optionally substituted by one or more hydroxyl or C¿1-16? Alkyl groups; R?2¿ represents hydrogen or C¿1-16? alkyl; X represents ethylene or a group of formula CR?eRf¿ wherein R?e and Rf¿ independently represent hydrogen or C1-14 alkyl or R?e and Rf¿ may together with the carbon atom to which they are attached form a C¿3-8? cycloalkyl group; R?3 and R4¿ independently represent hydrogen or C¿1-14? alkyl; Z represents a bond, CO, SO2, CR?9R6(CH¿2)n, (CH2)nCR?9R6, CHR6(CH¿2)nO, CHR6(CH2)nS, CHR6(CH2)nOCO, CHR6(CH2)nCO, COCHR6(CH2)n or SO2CHR6(CH2)n; n represents an integer from 0 to 4; processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

公开(公告)号：EP1567511A1

公开(公告)日：2005-08-31

申请号：EP03772221.2

申请日：2003-10-14

申请人： GLAXO GROUP LIMITED

发明人： ANCLIFF, Rachael ,  ELDRED, Colin David ,  FOGDEN, Yvonne C ,  HANCOCK, Ashley Paul ,  HEIGHTMAN, Thomas DanielGlaxoSmithKline ,  HOBBS, Heather ,  HODGSON, Simon Teanby ,  LINDON, Matthew J ,  WILSON, David MatthewGlaxoSmithKline

IPC分类号： C07D295/18 ,  C07D317/68 ,  C07D307/85 ,  C07D405/06 ,  C07D243/08 ,  C07D295/22 ,  C07D295/20 ,  C07D295/12 ,  C07D333/38 ,  C07D491/04 ,  C07D403/12 ,  C07D401/12 ,  C07D311/90 ,  C07D487/08 ,  A61K31/496 ,  A61P11/00 ,  A61P25/00

CPC分类号： C07D213/81 ,  C07D209/42 ,  C07D211/46 ,  C07D213/50 ,  C07D213/64 ,  C07D215/40 ,  C07D215/46 ,  C07D215/50 ,  C07D239/28 ,  C07D243/08 ,  C07D265/36 ,  C07D277/62 ,  C07D285/06 ,  C07D295/088 ,  C07D295/185 ,  C07D295/192 ,  C07D295/215 ,  C07D295/26 ,  C07D307/79 ,  C07D307/85 ,  C07D311/84 ,  C07D317/68 ,  C07D333/38 ,  C07D405/06 ,  C07D487/08 ,  C07D491/04

摘要： The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.

公开(公告)号：EP2205585A1

公开(公告)日：2010-07-14

申请号：EP08805283.2

申请日：2008-10-15

申请人： Glaxo Group Limited

发明人： GORE, Paul Martin ,  HANCOCK, Ashley Paul ,  HODGSON, Simon Teanby ,  KRANZ, Michael Joachim ,  PROCOPIOU, Panayiotis Alexandrou ,  VILE, Sadie

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  A61K31/4709 ,  A61P11/00 ,  A61P29/00 ,  A61P37/00

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D413/14

摘要： The present invention relates to compounds of formula (I) and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various diseases, such as allergic rhinitis.

公开(公告)号：EP1851201A1

公开(公告)日：2007-11-07

申请号：EP06709850.9

申请日：2006-02-22

申请人： GLAXO GROUP LIMITED

发明人： HANCOCK, Ashley Paul ,  HODGSON, Simon Teanby ,  VINADER BRUGAROLAS, Maria-Victoria ,  WASHINGTON, Melanie Lee

IPC分类号： C07D211/46 ,  A61K31/4545

CPC分类号： C07D211/46

摘要： The present invention relates to the compound, of Formula (I): and salts thereof, processes for its preparation, to compositions containing it and to its use in the treatment of various disorders, such as allergic rhinitis.

公开(公告)号：EP1495020A1

公开(公告)日：2005-01-12

申请号：EP03745300.8

申请日：2003-03-27

申请人： GLAXO GROUP LIMITED

发明人： ANCLIFF, Rachael Ann ,  COOK, Caroline Mary ,  ELDRED, Colin David ,  GORE, Paul Martin ,  HARRISON, Lee Andrew ,  HAYES, Martin Alistair ,  HODGSON, Simon Teanby ,  JUDD, Duncan Bruce ,  KEELING, Suzanne Elaine ,  LEWELL, Xiao Qing ,  MILLS, Gail ,  ROBERTSON, Graeme Michael ,  SWANSON, Stephen ,  WALKER, Andrew John ,  WILKINSON, Mark

IPC分类号： C07D413/12 ,  C07D241/08 ,  C07D309/38 ,  A61K31/5377 ,  A61P11/06 ,  A61P17/06 ,  A61P17/04 ,  A61P25/28 ,  A61P37/06 ,  A61P37/08 ,  A61P9/10 ,  A61P1/06 ,  A61P27/14

CPC分类号： C07D413/12

摘要： Compounds of formula (I); wherein: R1 represents substituted or unsubstituted heterocyclyl; Y represents -(CRnaRnb)n-; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 1 to 5; R2 represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R3 represents hydrogen or C1-6alkyl; and salts and solvates thereof are CCR-3 antagonists and are thus indicated to be useful in therapy.

公开(公告)号：EP1487827A1

公开(公告)日：2004-12-22

申请号：EP03712119.1

申请日：2003-03-27

申请人： GLAXO GROUP LIMITED

发明人： ANCLIFF, Rachael Ann ,  COOK, Caroline Mary ,  ELDRED, Colin David ,  GORE, Paul Martin ,  HARRISON, Lee Andrew ,  HAYES, Martin Alistair ,  HODGSON, Simon Teanby ,  JUDD, Duncan Bruce ,  KEELING, Suzanne Elaine ,  LEWELL, Xiao Qing ,  MILLS, Gail ,  ROBERTSON, Graeme Michael ,  SWANSON, Stephen ,  WALKER, Andrew John ,  WILKINSON, Mark

IPC分类号： C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D265/30 ,  C07C215/10 ,  A61K31/5377 ,  A61P29/00

CPC分类号： C07D265/30 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

摘要： Certain compounds of formula (I): wherein: R1 represents substituted or unsubstituted heteroaryl; Y represents -(CRnaRnb)n-; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 1 to 5;R2 represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R3 represents hydrogen or C1-6alkyl;and salts and solvates thereof are CCR-3 antagonists and are thus indicated to be useful in therapy.